Tagraxofusp to Eradicate Measurable Residual Disease in Patients With Acute Myeloid Leukemia

Inclusion Criteria: Age >= 18 years AML in first or second remission, including: Complete remission (CR), defined as bone marrow blasts < 5%, absence of circulating blasts, absence of extramedullary disease, absolute neutrophil count (ANC) >= 1,000/uL, platelet count > 100,000/uL Complete remission with incomplete hematologic recovery (CRi), defined as all CR criteria except for residual neutropenia (ANC < 1,000/uL) or residual thrombocytopenia (platelet count < 100,000/uL) Morphologic leukemia-free state with adequate marrow recovery, defined as bone marrow blasts < 5%, ANC >= 500/uL, and platelet count >= 20,000/uL Minimal residual disease positive >= 0.01% based on MPFC For participants in first remission, MRD positivity at any point from time of establishing first remission onward while still in first remission For participants in second remission, MRD positivity at any point from time of establishing second remission onward while still in second remission MRD must be repeated and remain positive if additional treatment is given prior to enrollment CD123 positivity on flow cytometry (partial, dim, or bright) from either: Conventional flow cytometry on marrow specimen from time of original diagnosis or first relapse High-sensitivity multiparametric flow cytometry on marrow specimen from time of MRD positivity Eastern Cooperative Oncology Group (ECOG) 0-2 Serum albumin level >= 3.2 g/dL in the absence of receiving albumin infusion Serum total bilirubin =< 1.5 mg/dL, unless considered due to Gilbert's disease or medication effect Aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase =< 2.5 times the upper limit of normal, unless considered due to medication effect (eg, azole therapy) Creatinine clearance >= 60 mL/min based on Cockcroft-Gault glomerular filtration rate (GFR) and serum creatinine (Cr) =< 1.8 mg/dL Ability to give full informed consent Females of reproductive potential (postmenopausal for less than 24 consecutive months) must have a negative pregnancy test within 1 week of initiating treatment and may not be breastfeeding Exclusion Criteria: MRD negativity < 0.01% at screening Intensive AML therapy within the past 14 days, or non-intensive targeted therapy within the past 7 days Cord blood as donor source Second malignancy that would be expected to limit survival within less than 2 years Cardiovascular disease that would result in high risk for toxicity, including: Uncontrolled or New York Heart Association (NYHA) class III or VI congestive heart failure Recurrent or uncontrolled angina Unstable angina, myocardial infarction, or stroke in past 6 months Uncontrolled hypertension Arrhythmia not controlled by medication Left ventricular ejection fraction < 50% History of coronary stent placement that requires mandatory continuation of dual antiplatelet therapy Uncontrolled intercurrent illness that includes but is not limited to: uncontrolled infection, disseminated intravascular coagulation, psychiatric illness/compliance issues that would limit compliance with study protocol Any medical condition that in the opinion of the investigator places the participant at unacceptable risk for toxicity to investigational therapy