Tambua Mapema Plus - to Discover HIV Infection Early and Prevent Onward Transmission (TMP)
HIV Infections
About this trial
This is an interventional prevention trial for HIV Infections focused on measuring HIV testing, ART, partner notification, PrEP
Eligibility Criteria
Inclusion Criteria:
- age from 18-39 years;
- not previously diagnosed with HIV infection; and
a score ≥2 on our risk score algorithm to identify persons at higher risk for AHI, with scoring as follows:
- age 18-29 years (1),
- fever (1),
- fatigue (1),
- body pains (1),
- diarrhea (1),
- sore throat (1), and
- genital ulcer disease (GUD) (3).
Eligibility criteria for partners of newly diagnosed cases with prevalent or acute HIV include:
- age over 18 years; and
- not previously diagnosed HIV infection.
Exclusion Criteria:
Patients not meeting inclusion criteria or those who are not willing or able to participate (e.g., due to illness or time constraints, or at the discretion of the study clinician) will be excluded.
Individuals at high risk for Intimate Partner Violence (IPV) are excluded from the aPS intervention, but eligible for all other components of the study.
Sites / Locations
- KEMRI Mtwapa
Arms of the Study
Arm 1
Arm 2
No Intervention
Active Comparator
Observation Period
Intervention Period
HIV testing will only be done if ordered by the primary care clinician. Individuals diagnosed with HIV who have not yet notified partners will be offered assisted partner notification at a 6-week visit.
Combination intervention with HIV-1 RNA testing followed by rapid tests if positive for HIV diagnosis, immediate ART if diagnosed, assisted partner notification with HIV-1 RNA testing of partners, and PrEP for uninfected partners in discordant relationships.