Tau PET Imaging in Opioid Use Disorder

Inclusion Criteria: OUD OD- group: 18-60 years-old Informed of the investigational nature of this study and able to provide written informed consent and participate in this study in accordance with institutional and federal guidelines prior to study-specific procedures. Participants are in current treatment for OUD, which must include being on a stable dose of medication for at least 30 days prior to the screening visit. Opioids are specified by the participant as their preferred drug No lifetime history of OD per self-report or medical record review. OUD OD+ group: 18-60 years-old Informed of the investigational nature of this study and able to provide written informed consent and participate in this study in accordance with institutional and federal guidelines prior to study-specific procedures. Participants are in current treatment for OUD, which must include being on a stable dose of medication for at least 30 days prior to the screening visit. Opioids are specified by the participant as their preferred drug A history of at least 1 opioid OD that required naloxone reversal that occurred 1-12 months prior to study enrollment, as per self-report and/or medical record review. Healthy Control (HC) group: 4. 18-60 years-old 5. Informed of the investigational nature of this study and able to provide written informed consent and participate in this study in accordance with institutional and federal guidelines prior to study-specific procedures. 6. Must have never met lifetime history for Opioid Use Disorder (as per DSM-5) and not used an opioid for any reason in the 30 days prior to screening by self-report, medical record review, and urine drug testing at screening. Exclusion Criteria: 14. HIV infection confirmed by an on-site rapid HIV test at screening. HIV affect neurocognitive function, even in otherwise asymptomatic individuals, which can confound the results of MRI testing. 15. Women who are pregnant or breast feeding will not be eligible for this study; a urine pregnancy test will be performed for women of child-bearing potential at the screening visit and on the days of the MRI and PET/CT scan visits. 16. At screening, the participant's weight is >350 lb. 17. Self-reported claustrophobia, which in the opinion of an investigator would interfere with acquisition of the structural MRI required for PET co-registration, and/or the PET scan itself. 18. Contraindications to MRI (e.g., metal in the body that cannot be removed and is not MRI compatible). An MRI screening form will be completed during screening to identify contraindications. 19. Screening lab values that indicate significant organ dysfunction that in the opinion of an investigator could compromise participant safety or successful participation in the study. 20. History of epilepsy or seizure disorder (that are not a result of substance use or substance withdrawal) as assessed by medical record review or self-report. 21. History of head trauma that in the opinion of an investigator may interfere with the uptake of applicable radiotracer as assessed by medical record review or self-report. 22. Current serious psychiatric disorder (bipolar disorder, schizophrenia, psychotic disorder, eating disorder, or major depression with suicidal ideation or psychotic features) identified by clinical examination or the structured psychiatric interview that could interfere with study participation or make it hazardous for the participant or staff to perform study procedures. 23. Self-reported heavy daily use of psychoactive substances in the past 30 days (prior to the screening visit), such as stimulants, cocaine, but not including nicotine, caffeine, cannabis (or opioids in the OUD groups) that could interfere with study performance. 24. Not able to provide a breath alcohol level of 0.000 (tested with handheld breath analyzer) at the scan study visit. 25. Inability to tolerate imaging procedures as determined by an investigator or treating physician 26. Any current medical condition, illness, or disorder assessed by medical record review and/or self-report that is considered by a physician or investigator to potentially compromise participant safety or their successful participation in the study