Tazemetostat and Venetoclax in Relapsed/Refractory Non-Hodgkin Lymphoma

Inclusion Criteria: Histologically confirmed, biopsy-proven diagnosis of FL or DLBCL. Subjects must have been treated with at least one prior line of therapy for lymphoma with evidence of disease progression. Subjects are eligible if they have progressed after ASCT OR if they are ineligible for ASCT Exclusion Criteria: Significant cardiovascular impairment, such as history of congestive heart failure, uncontrolled arterial hypertension, unstable angina, myocardial infarction, or stroke within 6 months of the first dose of study drug Known hypersensitivity to any of the study drugs History of other cancer (some exceptions apply) Known CNS (brain or spinal cord) involvement at diagnosis Richter's transformation from CLL Evidence of uncontrolled systemic infection (viral, bacterial, or fungal) Major surgery within 3 weeks prior to the start of study treatment Venous thrombosis or pulmonary embolism within the last 3 months before starting study Uncontrolled infection with human immunodeficiency virus (HIV) or human T-cell leukemia virus 1 Pregnant or lactating (people capable of becoming pregnant or getting someone else pregnant must be willing to use highly effective birth control) Malabsorption syndrome or other condition that precludes enteral route of administration Inability to swallow tablets Known allergy to both xanthine oxidase inhibitors and rasburicase Clinically significant history of liver disease, including but not limited to viral or other hepatitis, current alcohol abuse, or cirrhosis Active hepatitis C (defined as a positive HCV viral load) Chronic use of moderate or strong CYP3A4 modulators (inhibitor or inducer); chronic use of a P-gp inhibitor, or a P-gp substrate with a narrow therapeutic index; or use of certain other prohibited medications Prior exposure to either tazemetostat or venetoclax Prior history of T-LBL/T-ALL Previous solid organ transplant Requires the use of warfarin (because of potential drug-drug interactions that may potentially increase the exposure of warfarin) Vaccination with live vaccines within 28 days prior to treatment Consumed grapefruit or grapefruit products, Seville oranges (including marmalade containing Seville oranges), or star fruit within 3 days prior to the first dose of study drug