tDCS on Precuneus in MCS: Repeated Stimulations
Patients in Minimally Conscious State After a Severe Brain Injury
About this trial
This is an interventional treatment trial for Patients in Minimally Conscious State After a Severe Brain Injury focused on measuring disorders of consciousness, minimally conscious state, traumatic brain injury, stroke, transcranial direct current stimulation
Eligibility Criteria
Inclusion Criteria:
- post comatose patients
- patients in minimally conscious state
- patients with stable condition
- patients free of sedative drugs and Na+ or Ca++ blockers (e.g., carbamazepine) or NMDA receptor antagonist (e.g., dextromethorphan)
Exclusion Criteria:
- premorbid neurology antecedent
- patients in coma or vegetative state
- patients < 1 months after the acute brain injury
- patients with a metallic cerebral implant or a pacemaker (in line with the safety criteria for tDCS in humans)
Sites / Locations
Arms of the Study
Arm 1
Arm 2
Active Comparator
Sham Comparator
anodal stimulation
sham stimulation
Patients received anodal tDCS (on the precuneus ) every day for 5 days (tDCS of 2mA during 20minutes). A CRS-R is performed at baseline (before the first stimulation) and after each tDCS. A final CRS-R is performed 5 days after the end of the session to assess the potential long term effects of the tDCS.
Patients received sham tDCS (5 secondes of stimulation) every day for 5 days. A CRS-R is performed at baseline (before the first stimulation) and after each tDCS. A final CRS-R is performed 5 days after the end of the session.