TEAM-Project: Trial on the Effect of Anesthetics on Morbidity and Mortality
Coronary Artery Disease
About this trial
This is an interventional prevention trial for Coronary Artery Disease focused on measuring preconditioning, cardiac protection, morbidity, mortality, major non-cardiac surgery, cardiac mortality and morbidity, high cardiac perioperative risk
Eligibility Criteria
Inclusion Criteria: Patients scheduled for a non-cardiac surgical procedure of high or intermediate cardiac risk are eligible if they have documented coronary artery disease (CAD) or are at high risk of CAD. Exclusion Criteria: Ongoing medication with sulfonylurea derivatives (unless stopped ≥ 2 days before surgery) or theophylline Emergency surgery Unstable angina pectoris Preoperative hemodynamic instability Severe hepatic disease Renal insufficiency (creatinine clearance < 30 ml/min) Severe chronic obstructive pulmonary disease (forced expiratory volume in 1 second [FEV1] < 1 litre) Absence of written patient consent
Sites / Locations
- Kantonsspital
- University Hospital
- Bürgerspital
Arms of the Study
Arm 1
Arm 2
Active Comparator
Active Comparator
Inhalational anesthetic
Intravenous anesthetic, propofol
Sevoflurane will be used as the main anesthetic in this arm, and no propofol will be administered
Propofol will be used as the main anesthetic in this arm, and no inhalational anesthetic will be administered