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Teenagers: Impact of Eccentric eXercise Training on Overweight and Obesity (TEXTOO)

Primary Purpose

Adolescents (12 to 17 Years Old), Obese (BMI>90th Percentile)

Status

Unknown status

Phase

Not Applicable

Locations

France

Study Type

Interventional

Intervention

Cycling exercises

About this trial

This is an interventional other trial for Adolescents (12 to 17 Years Old) focused on measuring pediatric obesity, eccentric exercise, body composition, training program

Eligibility Criteria

12 Years - 17 Years (Child)All SexesDoes not accept healthy volunteers

Inclusion Criteria:

Adolescent (12 to 17 years old)
BMI>90th percentile
Post puberty (Tanner 3 to 5)
Inactive (<10 METS/h/week)
No other chronic disease (cardio pulmonary, osteo articulary or muscular diseases), no surgery during the last 3 months, no genetic obesity and no contraindication to physical activity

Exclusion Criteria:

Sites / Locations

CHU Clermont-FerrandRecruiting

Arms of the Study

Arm 1

Arm 2

Arm Type

Experimental

Arm Label

Concentric cycling exercise (CON)

eccentric cycling exercise (EXC)

Arm Description

40 obese adolescents will be randomized into 2 groups: CON or EXC

Outcomes

Primary Outcome Measures

change in total body fat mass (Dual X ray Absorptiometry)

Secondary Outcome Measures

aerobic capacities (VO2max)

isometric muscular lower limbs strength

isokinetic muscular lower limbs strength

rest energy expenditure (indirect calorimetry)

biological parameters (plasma lipid profile and insulin-resistance )

physical activity (actimetry and questionnaires)

food intakes (measurements and questionnaires)

quality of life (questionnaires)

segmental body composition (segmental fat and fat free mass, Dual X-ray Absorptiometry)

Full Information

NCT ID

NCT02925572

First Posted

September 26, 2016

Last Updated

March 6, 2017

Sponsor

University Hospital, Clermont-Ferrand

Collaborators

ONAPS : Observatoire National de l'Activité Physique et de la Sédentarité

1. Study Identification

Unique Protocol Identification Number

NCT02925572

Brief Title

Teenagers: Impact of Eccentric eXercise Training on Overweight and Obesity

Acronym

TEXTOO

Official Title

Impact of Muscular Training Program on Body Composition of Overweight and Obese Teenagers: classi201c Cycling Exercise in Concentric Versus Eccentric

Study Type

Interventional

2. Study Status

Record Verification Date

March 2017

Overall Recruitment Status

Unknown status

Study Start Date

January 1, 2017 (Actual)

Primary Completion Date

December 2019 (Anticipated)

Study Completion Date

January 2020 (Anticipated)

3. Sponsor/Collaborators

Responsible Party, by Official Title

Sponsor

Name of the Sponsor

University Hospital, Clermont-Ferrand

Collaborators

ONAPS : Observatoire National de l'Activité Physique et de la Sédentarité

4. Oversight

5. Study Description

Brief Summary

Nowadays, eccentric exercise can be realized in a dynamic way with an ergocycle which permits eccentric (ECC) lower limbs contractions at a defined power output. With this type of ergometer, O2 consumption (VO2) in ECC is three fold lower than in concentric (CON) for the same power output. Consequently, ECC program could be used in chronic disorders with limited capacities, such as obesity. The investigators hypothesis that an eccentric training program, as it will induce higher mechanical constraints, would improve body composition, especially by reducing fat mass. This effect could be explained by an increased rest energy expenditure and a better improvement in biological parameters (particularly lipid profile and insulin-resistance) after ECC training (versus CON training). This study aims to compare the modification of fat mass after an ECC program versus a CON program at the same VO2.. The secondary goal is to assess the physiological mechanisms involved in the modification of body composition.

Detailed Description

40 obese adolescents will be randomized into 2 groups: CON or EXC. The patients of ECC group will follow habituation sessions (2 weeks) to avoid the secondary muscular effects of high intensity eccentric exercise. The training program will last 12 weeks for the two groups. Before and after, each subjects will participate to the following measurements: total and segmental body composition (DXA), aerobic capacities (maximal incremental exercise test, VO2max), muscular lower limbs strength (isometric and isokinetic dynamometer), rest energy expenditure (indirect calorimetry), biological parameters (lipid profile, insulin-resistance), physical activity (actimetry), food intakes and quality of life (questionnaires).

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study

Adolescents (12 to 17 Years Old), Obese (BMI>90th Percentile)

Keywords

pediatric obesity, eccentric exercise, body composition, training program

7. Study Design

Primary Purpose

Other

Study Phase

Not Applicable

Interventional Study Model

Parallel Assignment

Masking

Participant

Allocation

Randomized

Enrollment

40 (Anticipated)

8. Arms, Groups, and Interventions

Arm Title

Concentric cycling exercise (CON)

Arm Type

Experimental

Arm Description

40 obese adolescents will be randomized into 2 groups: CON or EXC

Arm Title

eccentric cycling exercise (EXC)

Arm Type

Experimental

Arm Description

40 obese adolescents will be randomized into 2 groups: CON or EXC

Intervention Type

Other

Intervention Name(s)

Cycling exercises

Intervention Description

All measurements are performed before and after the training program (12 weeks)

Primary Outcome Measure Information:

Title

change in total body fat mass (Dual X ray Absorptiometry)

Time Frame