Back to resultsTesting Effect and Schizophrenia
Primary Purpose
Schizophrenia, Episodic Memory Deficits
Status
Completed
Phase
Not Applicable
Locations
France
Study Type
Interventional
Intervention
Retrieval practice effect using word pairs and cued recall tests with feedback
Sponsored by
About this trial
This is an interventional supportive care trial for Schizophrenia focused on measuring Schizophrenia, Episodic memory deficits
Eligibility Criteria
Inclusion Criteria:
- French is the native language, or acquired before 5 years old
- People must be able to understand and follow the trial instructions
Specific inclusion criteria (for patients) :
- Diagnostic of schizophrenia, according to the DSM -5, clinically stable
- The treatment must remain unchanged during the trial
Exclusion Criteria:
- Severe or acute cerebral disease
- Other actual psychiatric disorder
- Use of drugs with high anticholinergic effect
- Irregular use of benzodiazepines medication, or high dose of benzodiazepin (more than 2 mg of lorazepam per day or equivalent)
- Inappropriate use of drugs
Specific exclusion criteria (for healthy subjects) :
- Diagnostic of schizophrenia of a relative up to the third degree
Sites / Locations
- Centre Psychothérapique de Nancy
- Service de psychiatrie - Hôpital Civil - CHRU Strasbourg
Arms of the Study
Arm 1
Arm 2
Arm Type
Experimental
Active Comparator
Arm Label
Patients with schizophrenia
Healthy subjects
Arm Description
Outcomes
Primary Outcome Measures
Number of word pairs properly recalled
- The aim is to investigate the retrieval practice effect using word pairs and cued recall tests with feedback in patients with schizophrenia and healthy controls.
In the first phase (encoding), people study a list of 48 word pairs non semantically associated, then half of the pairs are presented in its completed form for two times, and for the other half the two subsequent re-exposure trials are framed as cued recall tests (the first word is presented and the subject has to remember and give orally the second word, and a feedback is given).
In the second phase (final test) which takes place 2 days later, all the 48 word pairs are presented as a cued recall test.
- We will compare in patients with schizophrenia and healthy controls final performance recall for information studied and recalled ("test" condition) to those for information studied and then re-studied ("re-study" condition).
Secondary Outcome Measures
Difference between final performance recall and memory span score
In each group (patients with schizophrenia and healthy controls) :
Difference between the final performance recall (see primary outcome measure) in "test" condition and "re-study" condition AND memory span score.
Full Information
NCT ID
NCT02150174
First Posted
May 26, 2014
Last Updated
October 4, 2017
Sponsor
University Hospital, Strasbourg, France
1. Study Identification
Unique Protocol Identification Number
NCT02150174
Brief Title
Testing Effect and Schizophrenia
Official Title
Retrieval Practice in Patients With Schizophrenia : an Exploratory Study Using Word Pairs
Study Type
Interventional
2. Study Status
Record Verification Date
September 2017
Overall Recruitment Status
Completed
Study Start Date
July 2014 (Actual)
Primary Completion Date
August 2015 (Actual)
Study Completion Date
August 2015 (Actual)
3. Sponsor/Collaborators
Responsible Party, by Official Title
Sponsor
Name of the Sponsor
University Hospital, Strasbourg, France
4. Oversight
Data Monitoring Committee
No
5. Study Description
Brief Summary
When people are tested on a previously learned material, they will latter remember it better even when compared to a condition where they can re-study it. This phenomenon is called retrieval practice and is supported by an extensive research literature mostly carried out in normal students. This paradigm begins to be used in cognitive remediation programs in patients suffering from memory difficulties.
The objective of this study is to investigate whether retrieval practice is spared in patients with schizophrenia.
If effective, this method could be used in cognitive remediation programs.
Since episodic memory difficulties are supposed to be secondary to deficits in the initiation/elaboration of efficient encoding and retrieval strategies our hypothesis is that retrieval practice is spared in schizophrenia
6. Conditions and Keywords
Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Schizophrenia, Episodic Memory Deficits
Keywords
Schizophrenia, Episodic memory deficits
7. Study Design
Primary Purpose
Supportive Care
Study Phase
Not Applicable
Interventional Study Model
Parallel Assignment
Masking
None (Open Label)
Allocation
Non-Randomized
Enrollment
40 (Actual)
8. Arms, Groups, and Interventions
Arm Title
Patients with schizophrenia
Arm Type
Experimental
Arm Title
Healthy subjects
Arm Type
Active Comparator
Intervention Type
Behavioral
Intervention Name(s)
Retrieval practice effect using word pairs and cued recall tests with feedback
Intervention Description
In the first phase (encoding), people study a list of 48 word pairs non semantically associated.
Then (initial test), they recall half of word pairs or restudy the other half.
In the second phase (final test) which takes place 2 days later, they recall all the 48 the word pairs.
Primary Outcome Measure Information:
Title
Number of word pairs properly recalled
Description
- The aim is to investigate the retrieval practice effect using word pairs and cued recall tests with feedback in patients with schizophrenia and healthy controls.
In the first phase (encoding), people study a list of 48 word pairs non semantically associated, then half of the pairs are presented in its completed form for two times, and for the other half the two subsequent re-exposure trials are framed as cued recall tests (the first word is presented and the subject has to remember and give orally the second word, and a feedback is given).
In the second phase (final test) which takes place 2 days later, all the 48 word pairs are presented as a cued recall test.
- We will compare in patients with schizophrenia and healthy controls final performance recall for information studied and recalled ("test" condition) to those for information studied and then re-studied ("re-study" condition).
Time Frame
Final test : 2 days after the first experimental session
Secondary Outcome Measure Information:
Title
Difference between final performance recall and memory span score
Description
In each group (patients with schizophrenia and healthy controls) :
Difference between the final performance recall (see primary outcome measure) in "test" condition and "re-study" condition AND memory span score.
Time Frame
Final test : 2 days after the first experimental session
10. Eligibility
Sex
All
Minimum Age & Unit of Time
18 Years
Maximum Age & Unit of Time
60 Years
Accepts Healthy Volunteers
Accepts Healthy Volunteers
Eligibility Criteria
Inclusion Criteria:
French is the native language, or acquired before 5 years old
People must be able to understand and follow the trial instructions
Specific inclusion criteria (for patients) :
Diagnostic of schizophrenia, according to the DSM -5, clinically stable
The treatment must remain unchanged during the trial
Exclusion Criteria:
Severe or acute cerebral disease
Other actual psychiatric disorder
Use of drugs with high anticholinergic effect
Irregular use of benzodiazepines medication, or high dose of benzodiazepin (more than 2 mg of lorazepam per day or equivalent)
Inappropriate use of drugs
Specific exclusion criteria (for healthy subjects) :
- Diagnostic of schizophrenia of a relative up to the third degree
Facility Information:
Facility Name
Centre Psychothérapique de Nancy
City
Laxou Cedex
ZIP/Postal Code
54521
Country
France
Facility Name
Service de psychiatrie - Hôpital Civil - CHRU Strasbourg
City
Strasbourg
ZIP/Postal Code
67091 Cedex
Country
France
12. IPD Sharing Statement
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Testing Effect and Schizophrenia
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