Testing the Addition of the Drug Atezolizumab to the Usual Radiation Treatment for Patients With Early Non-small Cell Lung Cancer
Lung Non-Small Cell Carcinoma, Stage I Lung Cancer AJCC v8, Stage II Lung Cancer AJCC v8
About this trial
This is an interventional treatment trial for Lung Non-Small Cell Carcinoma
Eligibility Criteria
Inclusion Criteria:
- Patient must have histologically or cytologically proven stage I-IIA or limited T3N0M0 non-small cell lung cancer (NSCLC), without radiographic evidence of nodal or distant involvement (N0M0). Patient may have T3 disease with the exclusion of pericardial involvement. Patients with multifocal tumors with no more than two lesions confirmed or suspected to be synchronous early stage NSCLCs are eligible provided at least one lesion is histologically or cytologically proven to be NSCLC and meets one or more high-risk features
Disease must have one or more of the following high-risk features:
- Tumor diameter >= 2 cm (inclusive of any non-solid, ground glass component) as assessed by diagnostic computed tomography CT
- Tumor standard uptake value (SUV) max >= 6.2 as assessed by fludeoxyglucose F-18 (FDG) positron emission tomography (PET)/CT
- Moderately differentiated, poorly differentiated, or undifferentiated histology
- Patient must have undergone diagnostic chest CT with or without contrast (IV contrast preferred) within 42 days prior to randomization. PET-CT may be used if the CT portion is of comparable diagnostic quality to a stand-alone CT. All disease must be assessed within 42 days prior to randomization
- Patient must have undergone FDG PET/CT of chest within 90 days prior to randomization
- Patient must have undergone history and physical examination within 28 days prior to randomization
- Patient must be medically or surgically inoperable as documented by a board certified thoracic surgeon or multi-disciplinary tumor board consensus OR patient's unwillingness to undergo surgical resection must be clearly documented
- Patient must be >= 18 years old
- Patient must have Zubrod performance status of 0-2
- Patient must have adequate liver function defined as aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 3 x institutional upper level of normal (IULN) within 28 days prior to randomization
- Patient must have adequate renal function defined as calculated creatinine clearance >= 30 mL/min using the following formula. The serum creatinine value used in the calculation must have been collected within 28 days prior to randomization
- Patient must have absolute neutrophil count (ANC), platelets, and hemoglobin measured within 28 days prior to randomization. The purpose of these tests is to collect baseline values to compare with on-treatment values
- Patient must have thyroid-stimulating hormone (TSH) measured within 28 days prior to randomization. The purpose of this test is to collect baseline values to compare with on-treatment values
Patient must be tested for hepatitis B within 28 days prior to randomization. Patient must not have active (chronic or acute) hepatitis B virus (HBV) infection. Patients may have past or resolved HBV infection
- Active HBV is defined as having a positive hepatitis B surface antigen (HBsAg) test
- Past or resolved HBV is defined as having a negative HBsAG test and a positive total hepatitis B core antibody (HBcAb) test
Patient must be tested for hepatitis C within 28 days prior to randomization. Patient must not have active hepatitis C virus (HCV) infection
- Active HCV is defined as having a positive HCV antibody test followed by a positive HCV ribonucleic acid (RNA) test
- Patient must have pulmonary function testing documented within 90 days prior to randomization
- Patients with known human immunodeficiency virus (HIV) infection must be receiving anti-retroviral therapy and have an undetectable viral load at their most recent viral load test within 6 months prior to randomization
- Patient must not have a history of clinically significant interstitial lung disease or evidence of active pneumonitis on the screening chest CT
- Patients must not have a prior or concurrent malignancy whose natural history or treatment has the potential (in the opinion of the treating physician) to interfere with the safety or efficacy assessment of the investigational regimen
- Patients must not be pregnant due to the potential teratogenic side effects of the protocol treatment. Women of reproductive potential and men must have agreed to use an effective contraception method for the duration of protocol treatment, and for 5 months (150 days) after the last dose of atezolizumab. A woman is considered to be of "reproductive potential" if she has had a menses at any time in the preceding 12 consecutive months. In addition to routine contraceptive methods, "effective contraception" also includes heterosexual celibacy and surgery intended to prevent pregnancy (or with a side-effect of pregnancy prevention) defined as a hysterectomy, bilateral oophorectomy or bilateral tubal ligation. However, if at any point a previously celibate patient chooses to become heterosexually active during the time period for use of contraceptive measures outlined in the protocol, he/she is responsible for beginning contraceptive measures. Because there is an unknown but potential risk for adverse events in nursing infants secondary to treatment of the mother with atezolizumab, breastfeeding must be discontinued prior to randomization
- Patients of reproductive potential must have a negative serum pregnancy test within 14 days prior to randomization
- Patient must agree to have specimens submitted for translational medicine and banking
- Patients must be informed of the investigational nature of this study and must sign and give written informed consent in accordance with institutional and federal guidelines
- As a part of the OPEN registration process the treating institution's identity is provided in order to ensure that the current (within 365 days) date of institutional review board approval for this study has been entered in the system
- Patients who can complete quality of life instruments in English, French, or Spanish must agree to complete the questionnaires at the protocol-specified time points
Exclusion Criteria:
- Patient must not have evidence of hilar or mediastinal nodal involvement. Any patient with radiographically suspicious hilar or mediastinal nodes (including features such as non-calcified nodes with a short axis diameter > 1 cm, abnormal morphology, and/or elevated FDG avidity) must undergo cytologic sampling of suspicious nodes to rule out involvement prior to randomization. Mediastinal nodal sampling for other patients is optional. For cases in which the treating physician/multidisciplinary opinion is used to define nodes as "non-suspicious" (such as long-standing, stable enlarged nodes from other medical causes), the rationale must be clearly documented within the medical record
- Patient must not have received any prior treatment for the current NSCLC diagnosis
- Patient must not have undergone prior radiation to overlapping regions of the chest that, in the opinion of the treatment physician, will interfere with protocol treatment
- Patient must not have received treatment with systemic immunostimulatory or immunosuppressive agents, including corticosteroids, within 14 days prior to randomization
- Patient must not have significant cardiovascular disease (New York Heart Association [NYHA] class II or greater)
- Patient must not have myocardial infarction within 90 days prior to randomization
- Patient must not have unstable arrhythmias or unstable angina
Patient must not have known left ventricular ejection fraction (LVEF) < 40% within 28 days prior to randomization
- NOTE: Assessment of LVEF by echocardiogram or multigated acquisition (MUGA) is not an eligibility requirement, but if a standard of care echocardiogram or MUGA was clinically indicated, the LVEF must not be < 40% within 28 days prior to randomization
- Patient must not have had an infection >= grade 3 (Common Terminology Criteria for Adverse Events [CTCAE] version 5.0) within 28 days prior to randomization
- Patient must not have an active autoimmune disease that has required systemic treatment in past two years (i.e., with use of disease modifying agents, corticosteroids or immunosuppressive drugs). Replacement therapy (e.g., thyroxine, insulin, or physiologic corticosteroid replacement therapy for adrenal or pituitary insufficiency) is not considered a form of systemic treatment and is allowed
- Patients must not have known active tuberculosis
Patients must not have received a live, attenuated vaccine within 28 days prior to randomization
- NOTE: All Coronavirus disease 2019 (COVID-19) vaccines that have received Food and Drug Administration (FDA) approval or FDA emergency use authorization are acceptable
- Patients must not have a known history of allergic reactions attributed to compounds of similar chemical or biologic composition to atezolizumab
- Patients must not have a known history of severe allergic, anaphylactic, or other hypersensitivity reactions to chimeric antibodies, fusion proteins, or Chinese hamster ovary cell products or to any component of the atezolizumab formulation
Sites / Locations
- Providence Alaska Medical CenterRecruiting
- NEA Baptist Memorial Hospital and Fowler Family Cancer Center - JonesboroRecruiting
- University of Arkansas for Medical SciencesRecruiting
- Kaiser Permanente-Deer Valley Medical CenterRecruiting
- AIS Cancer Center at San Joaquin Community HospitalRecruiting
- Alta Bates Summit Medical Center-Herrick CampusRecruiting
- Tower Cancer Research FoundationRecruiting
- Kaiser Permanente DublinRecruiting
- Kaiser Permanente-FremontRecruiting
- Kaiser Permanente-FresnoRecruiting
- Loma Linda University Medical CenterRecruiting
- Veterans Affairs Loma Linda Healthcare SystemRecruiting
- Tibor Rubin VA Medical CenterRecruiting
- Los Angeles County-USC Medical CenterRecruiting
- USC / Norris Comprehensive Cancer CenterRecruiting
- Cedars Sinai Medical CenterRecruiting
- Fremont - Rideout Cancer CenterRecruiting
- Memorial Medical CenterRecruiting
- Kaiser Permanente-ModestoRecruiting
- Kaiser Permanente-OaklandRecruiting
- Saint Joseph Hospital - OrangeRecruiting
- UC Irvine Health/Chao Family Comprehensive Cancer CenterRecruiting
- Desert Regional Medical CenterRecruiting
- Kaiser Permanente-RichmondRecruiting
- Kaiser Permanente-RosevilleRecruiting
- Sutter Cancer Centers Radiation Oncology Services-RosevilleRecruiting
- Sutter Roseville Medical CenterRecruiting
- The Permanente Medical Group-Roseville Radiation OncologyRecruiting
- Kaiser Permanente Downtown CommonsRecruiting
- Sutter Medical Center SacramentoRecruiting
- University of California Davis Comprehensive Cancer CenterRecruiting
- Kaiser Permanente-South SacramentoRecruiting
- California Pacific Medical Center-Pacific CampusRecruiting
- Kaiser Permanente-San FranciscoRecruiting
- Veterans Affairs Medical Center - San FranciscoRecruiting
- Kaiser Permanente-Santa Teresa-San JoseRecruiting
- Kaiser Permanente San LeandroRecruiting
- Kaiser San Rafael-GallinasRecruiting
- Kaiser Permanente Medical Center - Santa ClaraRecruiting
- Kaiser Permanente-Santa RosaRecruiting
- Kaiser Permanente Cancer Treatment CenterRecruiting
- Kaiser Permanente-South San FranciscoRecruiting
- Kaiser Permanente-StocktonRecruiting
- Gene Upshaw Memorial Tahoe Forest Cancer CenterRecruiting
- Kaiser Permanente Medical Center-VacavilleRecruiting
- Kaiser Permanente-VallejoRecruiting
- Kaiser Permanente-Walnut CreekRecruiting
- Presbyterian Intercommunity HospitalRecruiting
- Rocky Mountain Regional VA Medical CenterRecruiting
- UCHealth University of Colorado HospitalRecruiting
- Penrose-Saint Francis HealthcareRecruiting
- UCHealth Memorial Hospital CentralRecruiting
- Memorial Hospital NorthRecruiting
- Kaiser Permanente-FranklinRecruiting
- Poudre Valley Hospital
- Cancer Care and Hematology-Fort Collins
- North Colorado Medical Center
- UCHealth Greeley Hospital
- Kaiser Permanente-Rock CreekRecruiting
- Kaiser Permanente-Lone TreeRecruiting
- Medical Center of the Rockies
- McKee Medical Center
- Smilow Cancer Hospital Care Center-FairfieldRecruiting
- Smilow Cancer Hospital Care Center at GreenwichRecruiting
- Smilow Cancer Hospital Care Center - GuilfordRecruiting
- Smilow Cancer Hospital-Hamden Care CenterRecruiting
- Yale UniversityRecruiting
- Yale-New Haven Hospital North Haven Medical CenterRecruiting
- Smilow Cancer Hospital Care Center-TrumbullRecruiting
- Smilow Cancer Hospital Care Center - WaterfordRecruiting
- Bayhealth Hospital Kent CampusRecruiting
- Beebe South Coastal Health CampusRecruiting
- Helen F Graham Cancer CenterRecruiting
- Medical Oncology Hematology Consultants PARecruiting
- Beebe Health CampusRecruiting
- GenesisCare USA - Aventura FP
- GenesisCare USA - Aventura
- Jupiter Medical CenterRecruiting
- GenesisCare USA - Plantation
- Florida Cancer Specialists - SarasotaRecruiting
- Florida Cancer Specialists - Sarasota DowntownRecruiting
- Sarasota Memorial HospitalRecruiting
- Sarasota Memorial Health Care Center at University ParkwayRecruiting
- Augusta Oncology Associates PC-D'AntignacRecruiting
- Augusta University Medical CenterRecruiting
- Memorial Health University Medical CenterRecruiting
- Lewis Cancer and Research Pavilion at Saint Joseph's/CandlerRecruiting
- Hawaii Cancer Care - Westridge
- Pali Momi Medical Center
- Hawaii Cancer Care Inc - Waterfront Plaza
- Queen's Cancer Cenrer - POB I
- Queen's Medical Center
- Straub Clinic and Hospital
- Queen's Cancer Center - Kuakini
- The Cancer Center of Hawaii-Liliha
- Saint Alphonsus Cancer Care Center-BoiseRecruiting
- Saint Alphonsus Cancer Care Center-CaldwellRecruiting
- Saint Alphonsus Cancer Care Center-NampaRecruiting
- Saint Joseph Medical CenterRecruiting
- Illinois CancerCare-BloomingtonRecruiting
- Illinois CancerCare-CantonRecruiting
- Illinois CancerCare-CarthageRecruiting
- Jesse Brown Veterans Affairs Medical CenterRecruiting
- University of IllinoisRecruiting
- Decatur Memorial HospitalRecruiting
- Crossroads Cancer CenterRecruiting
- Illinois CancerCare-EurekaRecruiting
- Illinois CancerCare-GalesburgRecruiting
- Western Illinois Cancer Treatment CenterRecruiting
- Illinois CancerCare-Kewanee ClinicRecruiting
- Illinois CancerCare-MacombRecruiting
- Loyola University Medical CenterRecruiting
- Illinois CancerCare-Ottawa ClinicRecruiting
- Illinois CancerCare-PekinRecruiting
- Illinois CancerCare-PeoriaRecruiting
- OSF Saint Francis Radiation Oncology at Peoria Cancer CenterRecruiting
- Methodist Medical Center of IllinoisRecruiting
- OSF Saint Francis Medical CenterRecruiting
- Illinois CancerCare-PeruRecruiting
- Illinois CancerCare-PrincetonRecruiting
- SwedishAmerican Regional Cancer Center/ACTRecruiting
- Southern Illinois University School of MedicineRecruiting
- Springfield ClinicRecruiting
- Memorial Medical CenterRecruiting
- Carle Cancer CenterRecruiting
- Community Cancer Center SouthRecruiting
- McFarland Clinic - AmesRecruiting
- Medical Oncology and Hematology Associates-West Des MoinesRecruiting
- Mercy Cancer Center-West LakesRecruiting
- Greater Regional Medical CenterRecruiting
- Mercy Medical Center - Des MoinesRecruiting
- Mission Cancer and Blood - LaurelRecruiting
- Mercy Medical Center-West LakesRecruiting
- LSU Health Baton Rouge-North ClinicRecruiting
- Louisiana Hematology Oncology Associates LLCRecruiting
- Mary Bird Perkins Cancer CenterRecruiting
- Our Lady of the Lake Physicians Group - Medical OncologyRecruiting
- Mary Bird Perkins Cancer Center - Houma
- Terrebonne General Medical Center
- East Jefferson General HospitalRecruiting
- UM Saint Joseph Medical CenterRecruiting
- Beverly HospitalRecruiting
- Lahey Hospital and Medical CenterRecruiting
- Addison Gilbert HospitalRecruiting
- Winchester HospitalRecruiting
- Saint Joseph Mercy HospitalRecruiting
- Saint Joseph Mercy BrightonRecruiting
- Saint Joseph Mercy CantonRecruiting
- Saint Joseph Mercy ChelseaRecruiting
- Michigan Healthcare Professionals Clarkston
- Beaumont Hospital - DearbornRecruiting
- Ascension Saint John HospitalRecruiting
- Michigan Healthcare Professionals Farmington
- Beaumont Hospital - Farmington HillsRecruiting
- Genesys Hurley Cancer InstituteRecruiting
- West Michigan Cancer CenterRecruiting
- Sparrow HospitalRecruiting
- Trinity Health Saint Mary Mercy Livonia HospitalRecruiting
- Michigan Healthcare Professionals Macomb
- Ascension Providence Hospitals - NoviRecruiting
- 21st Century Oncology-Pontiac
- William Beaumont Hospital-Royal OakRecruiting
- Ascension Saint Mary's HospitalRecruiting
- Oncology Hematology Associates of Saginaw Valley PCRecruiting
- Lakeland Medical Center Saint JosephRecruiting
- Marie Yeager Cancer CenterRecruiting
- Ascension Providence Hospitals - SouthfieldRecruiting
- Ascension Saint Joseph HospitalRecruiting
- Munson Medical CenterRecruiting
- William Beaumont Hospital - TroyRecruiting
- GenesisCare USA - Troy
- Saint John Macomb-Oakland HospitalRecruiting
- Saint Mary's Oncology/Hematology Associates of West BranchRecruiting
- University of Michigan Health - WestRecruiting
- Sanford Joe Lueken Cancer CenterRecruiting
- Miller-Dwan HospitalRecruiting
- Hennepin County Medical CenterRecruiting
- Park Nicollet Clinic - Saint Louis ParkRecruiting
- Regions HospitalRecruiting
- Baptist Memorial Hospital and Cancer Center-Golden TriangleRecruiting
- Baptist Cancer Center-GrenadaRecruiting
- University of Mississippi Medical Center
- Baptist Memorial Hospital and Cancer Center-Union CountyRecruiting
- Baptist Memorial Hospital and Cancer Center-OxfordRecruiting
- Baptist Memorial Hospital and Cancer Center-DesotoRecruiting
- Saint Francis Medical CenterRecruiting
- Parkland Health Center - FarmingtonRecruiting
- Delbert Day Cancer Institute at PCRMCRecruiting
- Missouri Baptist Medical CenterRecruiting
- Sainte Genevieve County Memorial HospitalRecruiting
- Mercy Hospital SpringfieldRecruiting
- CoxHealth South HospitalRecruiting
- Missouri Baptist Sullivan HospitalRecruiting
- Missouri Baptist Outpatient Center-Sunset HillsRecruiting
- Bozeman Deaconess HospitalRecruiting
- Saint James Community Hospital and Cancer Treatment CenterRecruiting
- Benefis Healthcare- Sletten Cancer InstituteRecruiting
- Nebraska Medicine-BellevueRecruiting
- CHI Health Saint Francis
- CHI Health Good SamaritanRecruiting
- Nebraska Medicine-Village PointeRecruiting
- University of Nebraska Medical CenterRecruiting
- Memorial Sloan Kettering Basking RidgeRecruiting
- Cooper Hospital University Medical Center
- Memorial Sloan Kettering MonmouthRecruiting
- Memorial Sloan Kettering BergenRecruiting
- Capital Health Medical Center-HopewellRecruiting
- MD Anderson Cancer Center at Cooper-Voorhees
- University of New Mexico Cancer CenterRecruiting
- Montefiore Medical Center-Einstein CampusRecruiting
- Montefiore Medical Center - Moses CampusRecruiting
- New York-Presbyterian/Brooklyn Methodist HospitalRecruiting
- Roswell Park Cancer Institute
- Memorial Sloan Kettering CommackRecruiting
- Mary Imogene Bassett HospitalRecruiting
- Cancer Institute at Saint Francis HospitalRecruiting
- Arnot Ogden Medical Center/Falck Cancer CenterRecruiting
- Memorial Sloan Kettering WestchesterRecruiting
- Mount Sinai ChelseaRecruiting
- Mount Sinai WestRecruiting
- Mount Sinai HospitalRecruiting
- Memorial Sloan Kettering Cancer CenterRecruiting
- State University of New York Upstate Medical UniversityRecruiting
- Memorial Sloan Kettering NassauRecruiting
- Good Samaritan Hospital Medical CenterRecruiting
- Messino Cancer Centers
- Rex Hematology Oncology Associates-CaryRecruiting
- Novant Health Presbyterian Medical CenterRecruiting
- Durham VA Medical CenterRecruiting
- Rex Hematology Oncology Associates-GarnerRecruiting
- CaroMont Regional Medical CenterRecruiting
- Margaret R Pardee Memorial HospitalRecruiting
- Novant Health Cancer Institute - HuntersvilleRecruiting
- Novant Health Cancer Institute - KernersvilleRecruiting
- Novant Health Cancer Institute - MatthewsRecruiting
- CarolinaEast Medical CenterRecruiting
- FirstHealth of the Carolinas-Moore Regional HospitalRecruiting
- UNC Rex HealthcareRecruiting
- UNC Rex Cancer Center of WakefieldRecruiting
- Novant Cancer Institute Radiation Oncology - SupplyRecruiting
- Novant Health Cancer Institute Radiation Oncology - WilmingtonRecruiting
- Novant Health New Hanover Regional Medical CenterRecruiting
- Novant Health Forsyth Medical CenterRecruiting
- Sanford Bismarck Medical CenterRecruiting
- Sanford Broadway Medical CenterRecruiting
- Sanford Roger Maris Cancer CenterRecruiting
- Miami Valley Hospital SouthRecruiting
- MetroHealth Medical CenterRecruiting
- Ohio State University Comprehensive Cancer CenterRecruiting
- The Mark H Zangmeister CenterRecruiting
- Dayton Blood and Cancer CenterRecruiting
- Miami Valley HospitalRecruiting
- Miami Valley Hospital NorthRecruiting
- Atrium Medical Center-Middletown Regional HospitalRecruiting
- Mount Carmel Grove City HospitalRecruiting
- Upper Valley Medical CenterRecruiting
- Saint Ann's HospitalRecruiting
- Genesis Healthcare System Cancer Care CenterRecruiting
- Cancer Centers of Southwest Oklahoma ResearchRecruiting
- University of Oklahoma Health Sciences CenterRecruiting
- Mercy Hospital Oklahoma CityRecruiting
- Clackamas Radiation Oncology CenterRecruiting
- Legacy Mount Hood Medical CenterRecruiting
- Legacy Good Samaritan Hospital and Medical CenterRecruiting
- Providence Portland Medical CenterRecruiting
- Providence Saint Vincent Medical CenterRecruiting
- Legacy Meridian Park HospitalRecruiting
- Lehigh Valley Hospital-Cedar CrestRecruiting
- Geisinger Medical CenterRecruiting
- Delaware County Memorial HospitalRecruiting
- Pocono Medical CenterRecruiting
- Penn State Milton S Hershey Medical CenterRecruiting
- Geisinger Medical Oncology-LewisburgRecruiting
- Thomas Jefferson University HospitalRecruiting
- Geisinger Cancer Services-PottsvilleRecruiting
- Reading HospitalRecruiting
- Geisinger Wyoming Valley/Henry Cancer CenterRecruiting
- Rhode Island HospitalRecruiting
- Saint Joseph's/Candler - Bluffton CampusRecruiting
- McLeod Regional Medical Center
- Saint Francis HospitalRecruiting
- Saint Francis Cancer CenterRecruiting
- Gibbs Cancer Center-PelhamRecruiting
- Spartanburg Medical CenterRecruiting
- Baptist Memorial Hospital and Cancer Center-ColliervilleRecruiting
- Ballad Health Cancer Care - KingsportRecruiting
- Wellmont Holston Valley Hospital and Medical CenterRecruiting
- Baptist Memorial Hospital and Cancer Center-MemphisRecruiting
- MD Anderson in The WoodlandsRecruiting
- M D Anderson Cancer CenterRecruiting
- MD Anderson West HoustonRecruiting
- MD Anderson League CityRecruiting
- MD Anderson in Sugar LandRecruiting
- Huntsman Cancer Institute/University of UtahRecruiting
- George E Wahlen Department of Veterans Affairs Medical Center
- Inova Schar Cancer InstituteRecruiting
- Augusta Health Center for Cancer and Blood DisordersRecruiting
- Southwest VA Regional Cancer CenterRecruiting
- Virginia Mason Medical CenterRecruiting
- Legacy Cancer Institute Medical Oncology and Day TreatmentRecruiting
- Legacy Salmon Creek HospitalRecruiting
- West Virginia University Charleston DivisionRecruiting
- Edwards Comprehensive Cancer CenterRecruiting
- Wheeling Hospital/Schiffler Cancer CenterRecruiting
- Langlade Hospital and Cancer CenterRecruiting
- ThedaCare Regional Cancer CenterRecruiting
- Ascension Saint Elizabeth HospitalRecruiting
- Northwest Wisconsin Cancer CenterRecruiting
- Ascension Southeast Wisconsin Hospital - Elmbrook CampusRecruiting
- Aurora Cancer Care-Southern Lakes VLCCRecruiting
- Ascension Calumet HospitalRecruiting
- HSHS Sacred Heart HospitalRecruiting
- Marshfield Medical Center-EC Cancer CenterRecruiting
- Ascension Saint Francis - Reiman Cancer CenterRecruiting
- Aurora Health Care Germantown Health CenterRecruiting
- Aurora Cancer Care-GraftonRecruiting
- Bellin Memorial HospitalRecruiting
- Saint Vincent Hospital Cancer Center Green BayRecruiting
- Saint Vincent Hospital Cancer Center at Saint Mary'sRecruiting
- Aurora BayCare Medical CenterRecruiting
- Aurora Cancer Care-Kenosha SouthRecruiting
- Gundersen Lutheran Medical CenterRecruiting
- Mayo Clinic Health System-Franciscan Healthcare
- William S Middleton VA Medical CenterRecruiting
- University of Wisconsin Carbone Cancer CenterRecruiting
- Aurora Bay Area Medical Group-MarinetteRecruiting
- Marshfield Medical Center-MarshfieldRecruiting
- Aspirus Medford HospitalRecruiting
- Ascension Columbia Saint Mary's Hospital OzaukeeRecruiting
- Aurora Cancer Care-MilwaukeeRecruiting
- Ascension Columbia Saint Mary's Hospital - MilwaukeeRecruiting
- Aurora Saint Luke's Medical CenterRecruiting
- Aurora Sinai Medical CenterRecruiting
- Marshfield Clinic-Minocqua CenterRecruiting
- ProHealth D N Greenwald CenterRecruiting
- ProHealth Oconomowoc Memorial HospitalRecruiting
- Ascension Mercy HospitalRecruiting
- Vince Lombardi Cancer Clinic - OshkoshRecruiting
- Ascension All Saints HospitalRecruiting
- Aurora Cancer Care-RacineRecruiting
- Marshfield Medical Center-Rice LakeRecruiting
- Saint Vincent Hospital Cancer Center at SheboyganRecruiting
- Vince Lombardi Cancer Clinic-SheboyganRecruiting
- Ascension Saint Michael's HospitalRecruiting
- Marshfield Medical Center-River Region at Stevens PointRecruiting
- Saint Vincent Hospital Cancer Center at Sturgeon BayRecruiting
- Aurora Medical Center in SummitRecruiting
- Vince Lombardi Cancer Clinic-Two RiversRecruiting
- UW Cancer Center at ProHealth CareRecruiting
- Aspirus Regional Cancer CenterRecruiting
- Ascension Medical Group Southeast Wisconsin - Mayfair RoadRecruiting
- Aurora Cancer Care-Milwaukee WestRecruiting
- Aurora West Allis Medical CenterRecruiting
- Marshfield Medical Center - WestonRecruiting
- Aspirus Cancer Care - Wisconsin RapidsRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
Arm A (atezolizumab, SBRT)
Arm B (SBRT)
Patients receive atezolizumab IV over 30-60 minutes on day 1 of each cycle. Treatment repeats every 21 days for 8 cycles in the absence of disease progression or unacceptable toxicity. Starting on day 1 cycle 3, patients also undergo SBRT for 3-8 treatments every 2 days or QD over 1-3 weeks. Patients undergo blood sample collection throughout the trial.
Beginning 21 days after randomization, patients undergo SBRT for 3-8 treatments every 2 days or QD over 1-3 weeks. Patients undergo blood sample collection throughout the trial.