The ADAPTation to Therapeutic Resistance Training (ADAPT) Study

Inclusion Criteria: mechanical knee pain for at least three months present with clinical signs and symptoms of knee pain arising from the tibiofemoral or patellofemoral joint diagnosed by sport and exercise medicine physician and/or physiotherapist have reduced occupational employability medical grade secondary to their knee pain report progression of resistance training load within the patient's rehabilitation programme is limited by knee pain aged between 18 and 55 years available to attend for the entire duration of the RRU course and a review appointment 3-months following course. Exclusion Criteria: diagnosed tibial, femoral or patella fracture and/or dislocation; present with instability in the knee resulting from ligament deficiency present with clinical signs and symptoms of patellar tendinopathy have planned surgery over the study period restricted knee range of movement; clinical signs and symptoms of non-musculoskeletal or serious pathological condition (i.e. Inflammatory arthropathy, infection or tumour) or referred pain from non-local pain source present with any physical impairment or co-morbidities (including cardio-vascular disease) precluding the safe participation in the rehabilitation programme and/or assessment procedures Cortico-steroid or analgesic injection intervention within the previous 7-days or previous knee surgery within the last 12 months to the affected limb Medical Exclusion Criteria: History of cardiovascular disease including hypertension, peripheral vascular disease, thrombosis/embolism, ischaemic heart disease, myocardial infarction. History of the following musculoskeletal disorders: rheumatoid arthritis, avascular necrosis or osteonecrosis, severe osteoarthritis. History of the following neurological disorders: Peripheral neuropathy, Alzheimer's disease, amyotrophic lateral sclerosis, Parkinson's disease, severe traumatic brain injury. Varicose veins in the lower limb Acute viral or bacterial upper or lower respiratory infection at screening Known or suspected lower limb chronic exertional compartment syndrome (CECS) Postsurgical swelling Surgical insertion of metal components at the position of cuff inflation History of any of the following conditions or disorders not previously listed: diabetes, active cancer History of elevated risk of unexplained fainting or dizzy spells during physical activity/exercise that causes loss of balance History of haemorrhagic stroke or exercise induced rhabdomyolysis