The Effect of Antecedent Hypoglycaemia on β2-adrenergic Sensitivity
Diabetes, Hypoglycemia Unawareness
About this trial
This is an interventional diagnostic trial for Diabetes focused on measuring Hypoglycemia unawareness, Diabetes, adrenal receptor, adrenerg respons, adrenergic beta-agonists, salbutamol
Eligibility Criteria
Inclusion Criteria: Informed consent Homozygous for Arginine at codon 16 or homozygous Gly at codon 16 No regular usage of medication other than oral contraceptives Exclusion Criteria: History of cerebrovascular, cardiovascular, or peripheral vascular disease Smoking Alcohol usage of more than 10 units per week Inability to abstain from xanthine-derivatives (coffee, tea, cola, chocolate, cacao) or alcohol for 2 days BMI above 30 kg/m2 Participation to any other trial in the preceding 3 months Ongoing disease of any kind Pregnancy
Sites / Locations
- Radboud University Nijmegen Medical Centre
Arms of the Study
Arm 1
Other
Hypoglycemia
Intrerfvention is a hypoglycemic stimulus