The Effect of Continued Mechanical Ventilation on the Occurrence of Myocardial Ischemia (VENTMICS-II)
Cardiovascular Diseases, Coronary Artery Disease, Myocardial Ischemia
About this trial
This is an interventional treatment trial for Cardiovascular Diseases focused on measuring Cardiac surgery, Minimally invasive cardiac surgery, Endoscopic coronary artery bypass grafting, Harlequin syndrome, Ventilation
Eligibility Criteria
Inclusion Criteria:
- Patients older than 18 years old
- Patients undergoing their first elective endo-CABG procedure using peripheral cannulation for CPB
- Patients who are able to give their informed consent
- Patients who speak Dutch or French
Exclusion Criteria:
- Patients participating in another clinical trial
- Patients taking corticosteroids
- Patients with an ejection fraction < 25%
- Patients with lung diseases (chronic obstructive pulmonary disease (COPD), asthma)
- Patients where groin cannulation is not possible
Sites / Locations
- Jessa HospitalRecruiting
Arms of the Study
Arm 1
Arm 2
Active Comparator
Experimental
Control group
Ventilation group
Ventilation is discontinued after going on CPB and lungs are exposed to atmospheric pressure. Blood will be drawn: At baseline: before general anaesthesia, after start of CPB, after clamping the aorta, before unclamping the aorta, after the operation, 5 h after clamping the aorta, 12 hours after clamping the aorta, and 24 hours after aortic clamping
Ventilation is continued from going on CPB until clamping of the ascending aorta. Blood will be drawn: At baseline: before general anaesthesia, after start of CPB, after clamping the aorta, before unclamping the aorta, after the operation, 5 h after clamping the aorta, 12 hours after clamping the aorta, and 24 hours after aortic clamping