Back to resultsThe Effect of Dietary Nitrate Supplementation on Linear Running Sprint Performance, Agility and Vertical Jump Performance in a Rested and Fatigued State
Primary Purpose
Exercise Performance
Status
Completed
Phase
Not Applicable
Locations
Study Type
Interventional
Intervention
Beetroot
Placebo beverage
Sponsored by
About this trial
This is an interventional basic science trial for Exercise Performance
Eligibility Criteria
Inclusion Criteria:
- Male and female participants in self-reported good general health as assessed by the standard procedures described below and specifically meeting normal blood pressure range (systolic: 100-135, diastolic: 60-90) and body mass index (BMI) range (16.0-29.9)
- Range of 18-45 years of age
- Participants must participate in an intermittent exercise based sport (e.g. soccer, rugby, hockey), at a competitive level (i.e. competes in officiated matches/games).
- Understanding of the procedures to be undertaken as part of the study
- Willingness to participate in exercise testing and follow supplementation guidelines and other instructions provided by the experimenter
- Informed, voluntary, written consent to participate in the study
Exclusion Criteria:
- Known pulmonary, cardiovascular or metabolic disease
- Food allergies including phenylketonurea (PKU)
- Current regular use of any dietary supplement (excluding macronutrient based supplements) or previous use of any dietary supplement in the past 6 months that is known to have a lasting effect.
- Blood donation within 3 months prior to the start of the study
- Substance abuse within 2 years of the start of the study
- Smoking
- Any prescription and non-prescription medication which may impact saliva production (antidepressants, diuretics, analgesics, antihistamines, anti-hyper/hypo-tensives, anti-anxiety, appetite suppressants).
- Current or previous use of phosphodiesterase 5 (PDE5) inhibitors.
- Participation in another clinical trial within past 4 weeks.
Sites / Locations
Arms of the Study
Arm 1
Arm 2
Arm Type
Experimental
Placebo Comparator
Arm Label
Test Beet shot
Placebo beverage
Arm Description
Containing 385 mg nitrate
<0.1 mmol nitrate in sucrose solution with beet coloring
Outcomes
Primary Outcome Measures
Linear running sprint time
Linear running sprint in a rested and fatigued state
Secondary Outcome Measures
Full Information
1. Study Identification
Unique Protocol Identification Number
NCT03565523
Brief Title
The Effect of Dietary Nitrate Supplementation on Linear Running Sprint Performance, Agility and Vertical Jump Performance in a Rested and Fatigued State
Official Title
The Effect of Dietary Nitrate Supplementation on Linear Running Sprint Performance, Agility and Vertical Jump Performance in a Rested and Fatigued State
Study Type
Interventional
2. Study Status
Record Verification Date
June 2018
Overall Recruitment Status
Completed
Study Start Date
September 1, 2016 (Actual)
Primary Completion Date
March 31, 2017 (Actual)
Study Completion Date
April 30, 2017 (Actual)
3. Sponsor/Collaborators
Responsible Party, by Official Title
Sponsor
Name of the Sponsor
PepsiCo Global R&D
4. Oversight
Studies a U.S. FDA-regulated Drug Product
No
Studies a U.S. FDA-regulated Device Product
No
Data Monitoring Committee
No
5. Study Description
Brief Summary
Dietary nitrate (NO3-) supplementation has been shown to improve skeletal muscle contractility and fatigue resistance, particularly in fast-twitch (type II) muscle fibers. Furthermore, NO3- supplementation has been shown to speed reaction time. Taken together, these findings suggest that NO3- ingestion may be ergogenic during all-out sprint running and reactive agility tasks. Moreover, increasing muscle force production at high contraction speeds would be expected to translate into improved muscle power and, subsequently, improved performance in very explosive forms of exercise, such as vertical jumping. Therefore, the purpose of this investigation is to assess the effect of short term (5 days) NO3- supplementation on linear running sprint performance, reactive agility and vertical jump performance in a rested and fatigued state.
6. Conditions and Keywords
Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Exercise Performance
7. Study Design
Primary Purpose
Basic Science
Study Phase
Not Applicable
Interventional Study Model
Crossover Assignment
Masking
ParticipantInvestigator
Allocation
Randomized
Enrollment
32 (Actual)
8. Arms, Groups, and Interventions
Arm Title
Test Beet shot
Arm Type
Experimental
Arm Description
Containing 385 mg nitrate
Arm Title
Placebo beverage
Arm Type
Placebo Comparator
Arm Description
<0.1 mmol nitrate in sucrose solution with beet coloring
Intervention Type
Other
Intervention Name(s)
Beetroot
Intervention Description
Containing 385 mg nitrate
Intervention Type
Other
Intervention Name(s)
Placebo beverage
Intervention Description
<0.1 mmol nitrate in sucrose solution with beet coloring
Primary Outcome Measure Information:
Title
Linear running sprint time
Description
Linear running sprint in a rested and fatigued state
Time Frame
5 days
10. Eligibility
Sex
All
Minimum Age & Unit of Time
18 Years
Maximum Age & Unit of Time
45 Years
Accepts Healthy Volunteers
Accepts Healthy Volunteers
Eligibility Criteria
Inclusion Criteria:
Male and female participants in self-reported good general health as assessed by the standard procedures described below and specifically meeting normal blood pressure range (systolic: 100-135, diastolic: 60-90) and body mass index (BMI) range (16.0-29.9)
Range of 18-45 years of age
Participants must participate in an intermittent exercise based sport (e.g. soccer, rugby, hockey), at a competitive level (i.e. competes in officiated matches/games).
Understanding of the procedures to be undertaken as part of the study
Willingness to participate in exercise testing and follow supplementation guidelines and other instructions provided by the experimenter
Informed, voluntary, written consent to participate in the study
Exclusion Criteria:
Known pulmonary, cardiovascular or metabolic disease
Food allergies including phenylketonurea (PKU)
Current regular use of any dietary supplement (excluding macronutrient based supplements) or previous use of any dietary supplement in the past 6 months that is known to have a lasting effect.
Blood donation within 3 months prior to the start of the study
Substance abuse within 2 years of the start of the study
Smoking
Any prescription and non-prescription medication which may impact saliva production (antidepressants, diuretics, analgesics, antihistamines, anti-hyper/hypo-tensives, anti-anxiety, appetite suppressants).
Current or previous use of phosphodiesterase 5 (PDE5) inhibitors.
Participation in another clinical trial within past 4 weeks.
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Andy Jones, PhD
Organizational Affiliation
University of Exeter, Sport and Health Sciences department
Official's Role
Principal Investigator
12. IPD Sharing Statement
Plan to Share IPD
No
Learn more about this trial
The Effect of Dietary Nitrate Supplementation on Linear Running Sprint Performance, Agility and Vertical Jump Performance in a Rested and Fatigued State
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