The Effect of Nebulization of Alkaline Solution on Treating XDRAB Pneumonia With C/S Plus Minocycline (NAEDRAP)
Pneumonia
About this trial
This is an interventional treatment trial for Pneumonia focused on measuring Extensively Drug Resistant A. Baumannii
Eligibility Criteria
Inclusion Criteria:
- Age: 18 to 75 years old, male or female
- The pneumonia patients met the diagnostic criteria, and clinical pulmonary infection score (CPIS) ≥ 5;
- The sputum bacteriology detection only prompted Acinetobacter baumannii culture for pathogens concentration meets the diagnostic criteria of the Chinese hospital-acquired pneumonia diagnosis and treatment guidelines, 2002 edition of "Acinetobacter baumannii and susceptibility results show only 1 to 2 sensitive to antimicrobial drugs (polymyxin, minocycline or tegafur doxycycline);
- Cephalosporins or tetracyclines drug treatment without a history of allergies and contraindications;
- Be able to accept inhalation therapy.
- Informed consent gained
Exclusion Criteria:
- Refused to accept inhalation therapy
- Renal insufficiency, creatinine clearance (Cockcroft-Gault formula) (CLcr) 15 ml / min or less;
- Liver dysfunction, defined as Child-Pugh score B or C
- Within one week before the start of cefoperazone sulbactam, minocycline treatment.
Sites / Locations
- Xijing Hospital
Arms of the Study
Arm 1
Arm 2
Arm 3
Sham Comparator
Active Comparator
Experimental
no nebulization
nebulization with pH 7.4 solution
nebulization with pH 7.8 solution
Antibiotics protocol is C/S plus minocycline. That is Cefoperazone/ sulbactam 3.0g(intravenous infusion, q8h or q6h) combined with minocycline doxycycline 100mg (oral,q12h).No nebulization will given to these patients.
Patients will received the same antibiotics protocol with C/S plus minocycline and nebulization with pH 7.4 solution(Each time the volume of aerosol solution is 5ml, q8h).
Patients will received the same antibiotics protocol with C/S plus minocycline and nebulization with pH 7.8 solution(Each time the volume of aerosol solution is 5ml, q8h).