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The Effect of Positive and Negative Emotions on Brain Activity in Alcoholics and Nonalcoholics

Primary Purpose

Alcoholism, Healthy

Status
Completed
Phase
Locations
United States
Study Type
Observational
Intervention
Sponsored by
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
About
Eligibility
Locations
Outcomes
Full info

About this trial

This is an observational trial for Alcoholism focused on measuring Brain Imaging, Affect, Limbic System, Cerebral Blood Volume, Alcoholism, Emotion, Brain, Operant, Autonomic, Relapse, Normal Volunteer

Eligibility Criteria

12 Years - 65 Years (Child, Adult, Older Adult)All SexesAccepts Healthy Volunteers

INPATIENT ALCOHOLICS: We will study up to 150 male and 150 female individuals who meet criteria for alcohol use disorders and are between the age of 18 and 65 years. Inpatient alcoholics will be recruited from the NIAAA protocol 05-AA-0121, Assessment and treatment of people with alcohol drinking problems. Inclusion criteria (1) Are physically healthy; (2) Are between 18-65 years of age (since age effects FMRI signal in ways that have not yet been well-characterized); (2) Are right handed. Exclusion criteria: (1) Have ferromagnetic objects in their bodies which might be adversely affected by MRI including implanted pacemakers, medication pumps, aneurysm clips; metallic prostheses (including metal pins and rods, heart valves or cochlear implants, shrapnel fragments, permanent eye liner or small metal fragments in the eye that welders and other metal works may have- any doubt about presence of these objects will result in exclusion from this study), or if candidates are uncomfortable in small closed spaces (have claustrophobia), or cannot lie comfortably on their back for up to one hour; (2) Test HIV positive (since AIDS-related dementia compromises brain function); (3) Are not cleared on a neuromotor examination during the screening physical by the medically responsible staff; (4) Are currently receiving psychotropic medication for emotional distress; (5) Are pregnant or lactating; (6) Have symptoms of alcohol withdrawal as indicated by the most recent measurement within the past 30 days, as measured by the Clinical Institute Withdrawal Assessment (CIWA) score greater than 8; (7) Have active homicidal or suicidal ideation. RECOVERING ALCOHOLICS We will study up to 50 male and 50 female individuals who in the past have met criteria for alcohol use disorders and are between the age of 18 and 65 years. Recovering alcoholics must be at least 3 month without alcohol use, and will be recruited from the NIAAA protocol 05-AA-0121, Assessment and treatment of people with alcohol drinking problems. Inclusion criteria: Same as inpatient alcoholics. Exclusion criteria: Same as inpatient alcoholics. -HEALTHY NON-ALCOHOLICS: We will study up to 150 male and 150 female individuals who have never met criteria for an alcohol use disorder and are between the age of 18 and 65 years and will be recruited from the NIAAA protocol 98-AA-0009, Screening Evaluation for NIAAA Protocols. Inclusion criteria: Same as inpatient alcoholics. Exclusion criteria: Same as inpatient alcoholics (item 6 does not apply). -CHILDREN OF ALCOHOLICS: We will study up to 90 male and 90 female individuals who are biological children of at least one parent who met criteria for alcohol dependence and are between the age of 12 and 17 years. Inclusion criteria: Same as inpatient alcoholics except age range is between 12 and 17 years. Exclusion criteria: Same as inpatient alcoholics except age range is between 12 and 17 years (item 6 does not apply). -CHILDREN OF NON-ALCOHOLICS: We will study up to 90 male and 90 female individuals neither of whose biological parents met criteria for alcohol dependence and are between the age of 12 and 17 years. Inclusion criteria: Same as inpatient alcoholics except age range is between 12 and 17 years. Exclusion criteria: Same as inpatient alcoholics except age range is between 12 and 17 years (item 6 does not apply). -PARENTS OF CHILDREN WHO HAVE AT LEAST ONE PARENT WITH A HISTORY OF ALCOHOL DEPENDENCE: We will study up to 180 individuals who are the parent of a child who has at least one parent with a history of alcohol dependence. The person providing consent may be either a parent with the history of alcohol dependence or a parent without such a history. Inclusion criteria: Legally able to consent for child. Exclusion criteria: None. -PARENTS OF CHILDREN WITH NO FAMILY HISTORY OF ALCOHOL DEPENDENCE We will study up to 180 individuals who are the parent of a child neither of whose parents have a history of alcohol dependence. INCLUSION CRITERIA: Inclusion criteria: Legally able to consent for child. Exclusion criteria: None.

Sites / Locations

  • National Institutes of Health Clinical Center, 9000 Rockville Pike

Outcomes

Primary Outcome Measures

Secondary Outcome Measures

Full Information

First Posted
November 3, 1999
Last Updated
December 6, 2019
Sponsor
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
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1. Study Identification

Unique Protocol Identification Number
NCT00001675
Brief Title
The Effect of Positive and Negative Emotions on Brain Activity in Alcoholics and Nonalcoholics
Official Title
Functional Neuroanatomy of Positive and Negative Affect in Alcoholics and Non-Alcoholics
Study Type
Observational

2. Study Status

Record Verification Date
December 23, 2015
Overall Recruitment Status
Completed
Study Start Date
January 23, 1998 (undefined)
Primary Completion Date
undefined (undefined)
Study Completion Date
December 23, 2015 (undefined)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Sponsor
Name of the Sponsor
National Institute on Alcohol Abuse and Alcoholism (NIAAA)

4. Oversight

5. Study Description

Brief Summary
This study was designed to learn more about the areas of the brain involved in the experience of positive and negative emotions. Patients who would like to participate in this study will first undergo a screening process to see if they will be eligible for the study. Patients eligible to participate in the study will go through two sessions. During session one, researchers will attempt to evoke positive and negative emotions by showing patients slides of different emotion-arousing stimuli (pictures of pleasant and unpleasant scenes). While patients are viewing these slides, researchers will be measuring patient's heart rate, sweating, and eye-blinking. During session two, patients will undergo an MRI of the brain while seeing similar emotion-arousing pictures as in session one. In addition, patients may be asked to play a simple computer game for a reward of money while researchers use the MRI to measure brain activity. Researchers hope to develop methods to evoke positive and negative emotions and simultaneously (at the same time) see brain activation in normal volunteers, alcoholics, and recovered alcoholics.<TAB>
Detailed Description
Objective: The purpose of this protocol is two-fold: 1) to determine how individual differences in evoked brain responses relate to generalized trait personality and behavior differences (as assessed by psychometric questionnaire instruments and behavioral measures), and 2) to determine whether individual differences in evoked brain responses relate specifically to genetic polymorphisms in genes governing neurotransmitter activity. Study population: Healthy non-alcoholic adult volunteers, healthy adolescents aged 12 to 17 years (with or without a family history of alcohol use disorder), inpatient or outpatient alcoholics, and recovering alcoholics. Design: In this event-related functional magnetic resonance imaging (fMRI) study we will attempt to evoke positive and negative affect via several different standardized methods including: (1) pictures of emotion-arousing stimuli; (2) pictures of emotional facial expression; (3) cues signaling reward or punishment. This protocol is designed to cover many different functional magnetic imaging studies all using similar techniques to evoke and measure positive and negative affect in the brain. Most subjects will not participate in studies involving all the methods described in the protocol. Outcome measures: The outcome measure is differences in blood oxygenation dependent level (BOLD) signal measured using standard fMRI techniques and analyzed using AFNI software.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Alcoholism, Healthy
Keywords
Brain Imaging, Affect, Limbic System, Cerebral Blood Volume, Alcoholism, Emotion, Brain, Operant, Autonomic, Relapse, Normal Volunteer

7. Study Design

Enrollment
1194 (Actual)

10. Eligibility

Sex
All
Minimum Age & Unit of Time
12 Years
Maximum Age & Unit of Time
65 Years
Accepts Healthy Volunteers
Accepts Healthy Volunteers
Eligibility Criteria
INPATIENT ALCOHOLICS: We will study up to 150 male and 150 female individuals who meet criteria for alcohol use disorders and are between the age of 18 and 65 years. Inpatient alcoholics will be recruited from the NIAAA protocol 05-AA-0121, Assessment and treatment of people with alcohol drinking problems. Inclusion criteria (1) Are physically healthy; (2) Are between 18-65 years of age (since age effects FMRI signal in ways that have not yet been well-characterized); (2) Are right handed. Exclusion criteria: (1) Have ferromagnetic objects in their bodies which might be adversely affected by MRI including implanted pacemakers, medication pumps, aneurysm clips; metallic prostheses (including metal pins and rods, heart valves or cochlear implants, shrapnel fragments, permanent eye liner or small metal fragments in the eye that welders and other metal works may have- any doubt about presence of these objects will result in exclusion from this study), or if candidates are uncomfortable in small closed spaces (have claustrophobia), or cannot lie comfortably on their back for up to one hour; (2) Test HIV positive (since AIDS-related dementia compromises brain function); (3) Are not cleared on a neuromotor examination during the screening physical by the medically responsible staff; (4) Are currently receiving psychotropic medication for emotional distress; (5) Are pregnant or lactating; (6) Have symptoms of alcohol withdrawal as indicated by the most recent measurement within the past 30 days, as measured by the Clinical Institute Withdrawal Assessment (CIWA) score greater than 8; (7) Have active homicidal or suicidal ideation. RECOVERING ALCOHOLICS We will study up to 50 male and 50 female individuals who in the past have met criteria for alcohol use disorders and are between the age of 18 and 65 years. Recovering alcoholics must be at least 3 month without alcohol use, and will be recruited from the NIAAA protocol 05-AA-0121, Assessment and treatment of people with alcohol drinking problems. Inclusion criteria: Same as inpatient alcoholics. Exclusion criteria: Same as inpatient alcoholics. -HEALTHY NON-ALCOHOLICS: We will study up to 150 male and 150 female individuals who have never met criteria for an alcohol use disorder and are between the age of 18 and 65 years and will be recruited from the NIAAA protocol 98-AA-0009, Screening Evaluation for NIAAA Protocols. Inclusion criteria: Same as inpatient alcoholics. Exclusion criteria: Same as inpatient alcoholics (item 6 does not apply). -CHILDREN OF ALCOHOLICS: We will study up to 90 male and 90 female individuals who are biological children of at least one parent who met criteria for alcohol dependence and are between the age of 12 and 17 years. Inclusion criteria: Same as inpatient alcoholics except age range is between 12 and 17 years. Exclusion criteria: Same as inpatient alcoholics except age range is between 12 and 17 years (item 6 does not apply). -CHILDREN OF NON-ALCOHOLICS: We will study up to 90 male and 90 female individuals neither of whose biological parents met criteria for alcohol dependence and are between the age of 12 and 17 years. Inclusion criteria: Same as inpatient alcoholics except age range is between 12 and 17 years. Exclusion criteria: Same as inpatient alcoholics except age range is between 12 and 17 years (item 6 does not apply). -PARENTS OF CHILDREN WHO HAVE AT LEAST ONE PARENT WITH A HISTORY OF ALCOHOL DEPENDENCE: We will study up to 180 individuals who are the parent of a child who has at least one parent with a history of alcohol dependence. The person providing consent may be either a parent with the history of alcohol dependence or a parent without such a history. Inclusion criteria: Legally able to consent for child. Exclusion criteria: None. -PARENTS OF CHILDREN WITH NO FAMILY HISTORY OF ALCOHOL DEPENDENCE We will study up to 180 individuals who are the parent of a child neither of whose parents have a history of alcohol dependence. INCLUSION CRITERIA: Inclusion criteria: Legally able to consent for child. Exclusion criteria: None.
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Reza Momenan, Ph.D.
Organizational Affiliation
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Official's Role
Principal Investigator
Facility Information:
Facility Name
National Institutes of Health Clinical Center, 9000 Rockville Pike
City
Bethesda
State/Province
Maryland
ZIP/Postal Code
20892
Country
United States

12. IPD Sharing Statement

Citations:
PubMed Identifier
8938120
Citation
Breiter HC, Etcoff NL, Whalen PJ, Kennedy WA, Rauch SL, Buckner RL, Strauss MM, Hyman SE, Rosen BR. Response and habituation of the human amygdala during visual processing of facial expression. Neuron. 1996 Nov;17(5):875-87. doi: 10.1016/s0896-6273(00)80219-6.
Results Reference
background
PubMed Identifier
7965602
Citation
Depue RA, Luciana M, Arbisi P, Collins P, Leon A. Dopamine and the structure of personality: relation of agonist-induced dopamine activity to positive emotionality. J Pers Soc Psychol. 1994 Sep;67(3):485-98. doi: 10.1037//0022-3514.67.3.485.
Results Reference
background
PubMed Identifier
8876259
Citation
Grant S, London ED, Newlin DB, Villemagne VL, Liu X, Contoreggi C, Phillips RL, Kimes AS, Margolin A. Activation of memory circuits during cue-elicited cocaine craving. Proc Natl Acad Sci U S A. 1996 Oct 15;93(21):12040-5. doi: 10.1073/pnas.93.21.12040.
Results Reference
background

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The Effect of Positive and Negative Emotions on Brain Activity in Alcoholics and Nonalcoholics

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