The Effect of Repetitive Transcranial Magnetic Stimulation in Schizophrenia
Schizophrenia
About this trial
This is an interventional treatment trial for Schizophrenia
Eligibility Criteria
Inclusion Criteria:
- The patient met the diagnostic criteria for schizophrenia in DSM-IV;
- 18-55 years old;
- Right handed;
- On stable doses of psychotropic medications.
Exclusion Criteria:
- DSM-IV diagnosis of other Axis I disorders;
- Contraindications to TMS or MRI;
- Patients receiving ECT (electro-convulsive therapy) in last 6months;
- Left-handedness。
Sites / Locations
Arms of the Study
Arm 1
Arm 2
Active Comparator
Sham Comparator
active rTMS
sham rTMS
The Active rTMS: The magnetic head uses the Magro X100's "8"-shaped coil, and the intervention site is the cerebellar vermis (1 cm below the occipital carina). The stimulation intensity is gradually increased by the 80%-100% exercise threshold according to the patient's tolerance. The total number of stimulation pulses per day is 600, the basic frequency is 5 Hz, and one short burst stimulus is given every 200 milliseconds. In each short array, three single pulses with a frequency of 50 Hz are buried, and every 10 short bursts are stimulated for 8 s. A total of 200 short bursts of stimulation. Intervention once a day, 5 times a week, intervention for 2 weeks, a total of 10 times.
The sham rTMS: The sham stimulation method was to invert the "8" shaped coil, which was 180° to the scalp, and other intervention parameters were consistent with the study group.