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The Effect of the 3/7 vs 3X9 Method in Resistance Training on Metabolic Stress in Cardiac Rehabilitation

Primary Purpose

Heart Failure, Resistance Training, Coronary Artery Disease

Status

Recruiting

Phase

Not Applicable

Locations

Belgium

Study Type

Interventional

Intervention

Cardiac rehabilitation with 3/7 method

Cardiac rehabilitation with 3X9 method

About this trial

This is an interventional other trial for Heart Failure focused on measuring Cardiac rehabilition, exercise therapy, metabolic stress

Eligibility Criteria

18 Years - undefined (Adult, Older Adult)MaleDoes not accept healthy volunteers

Inclusion Criteria:

Clinical Coronary artery diseases
Heart failure with reduced ejection fraction

Exclusion Criteria:

angina
acutely decompensated heart failure
electrocardiographic evidence of ischemia
significant valvular disease
orthopedic/neurologic disorders that limited exercise

Sites / Locations

Erasme HospitalRecruiting

Arms of the Study

Arm 1

Arm 2

Arm Type

Experimental

Arm Label

CAD group

HFrEF group

Arm Description

Coronary artery diseases

Heart Failure with reduced Ejection Fraction

Outcomes

Primary Outcome Measures

Change in Lactate

mmol/l

change in Testosterone

nmol/l

change Glucocorticoid Cortisol

nmol/l

change in Growth Hormone

ng/ml

change in ph

venoust

change PCO2 venoust

mm Hg

Secondary Outcome Measures

Borg scale

Borg Rating of Perceived Exertion - Borg modified (0 = no exertion at all -10 maximal exertion)

Pleasure of the session scale

0 = worse 10 = better

Full Information

NCT ID

NCT05391620

First Posted

April 7, 2022

Last Updated

October 4, 2022

Sponsor

Université Libre de Bruxelles

1. Study Identification

Unique Protocol Identification Number

NCT05391620

Brief Title

The Effect of the 3/7 vs 3X9 Method in Resistance Training on Metabolic Stress in Cardiac Rehabilitation

Official Title

Acute Effects of the 3/7 Method and 3X9 Method in Resistance Training on Testosterone, Glucocorticoid Cortisol, Growth Hormone and Lactate in Heart Failure and Coronary Artery Disease During Cardiac Rehabilitation

Study Type

Interventional

2. Study Status

Record Verification Date

October 2022

Overall Recruitment Status

Recruiting

Study Start Date

March 15, 2022 (Actual)

Primary Completion Date

December 15, 2022 (Anticipated)

Study Completion Date

February 20, 2023 (Anticipated)

3. Sponsor/Collaborators

Responsible Party, by Official Title

Principal Investigator

Name of the Sponsor

Université Libre de Bruxelles

4. Oversight

Studies a U.S. FDA-regulated Drug Product

Studies a U.S. FDA-regulated Device Product

Data Monitoring Committee

5. Study Description

Brief Summary

The study proposes to measure the effect of resitance training (RT) (3/7 method) on biological markers of muscle hypertrophy in a cardiac population. 3/7 method consisting of five sets of an increasing number of repetitions (3 to 7) during successive sets and brief inter-set intervals (15 s). This method is compare to 3X9 method, 3 series of 9 repetitions with inter-set (1min).The training exercise consisted of contraction on machine (leg press, triceps press, leg curl, traction, leg extension) with load of ~ 70% of one repetition maximal (1RM). Before these trainings all subject perform HIIT on bicycles (2 min high intensity (80% Wmax) and 2 min low intensity (50% Wmax) during 30 minutes. The investigators collect blood sample before exercice, after HIIT and after RT. It is randomized cross-over study.

Detailed Description

The subjects come on two different days minimum 2 days and maximum 10 days between the two tests. They were instructed to avoid exercise the day before they participated in the study. The investigators collect blood 2 minutes after endurance training (HIIT) and 2 min after RT training.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study

Heart Failure, Resistance Training, Coronary Artery Disease

Keywords

Cardiac rehabilition, exercise therapy, metabolic stress

7. Study Design

Primary Purpose

Other

Study Phase

Not Applicable

Interventional Study Model

Crossover Assignment

Masking

InvestigatorOutcomes Assessor

Allocation

Randomized

Enrollment

30 (Anticipated)

8. Arms, Groups, and Interventions

Arm Title

CAD group

Arm Type

Experimental

Arm Description

Coronary artery diseases

Arm Title

HFrEF group

Arm Type

Experimental

Arm Description

Heart Failure with reduced Ejection Fraction

Intervention Type

Other

Intervention Name(s)

Cardiac rehabilitation with 3/7 method

Other Intervention Name(s)

3/7 method

Intervention Description

HIIT ( 2 min 80% wmax: 2 min 50% wmax) during 30 minutes 3/7 method 3 rep (15 sec of rest), 4 rep (15 sec), 5 rep (15 sec), 6 rep (15 sec), 7 rep. (total volume : 25 repetitions) at 70 of 1 repetition Leg press, Dips Press, Leg curl, Traction and Leg extension. 1 minute between each machine is planned.

Intervention Type

Other

Intervention Name(s)

Cardiac rehabilitation with 3X9 method

Other Intervention Name(s)

3X9 method

Intervention Description

HIIT ( 2 min 80% wmax: 2 min 50% wmax) during 30 minutes 3X9 method 9 rep 1 minute of rest, 9 rep (1 min) and 9 rep (total volume : 27 repetitions) at 70 of 1 repetition Leg press, Dips Press, Leg curl, Traction and Leg extension. 1 minute between each machine is planned

Primary Outcome Measure Information:

Title

Change in Lactate

Description

mmol/l

Time Frame