The Effect of Vitamin D on Fertility

Objective: To examine the effect of vitamin D supplements on the pregnancy and clinical pregnancy rate in embryo transfer cycles. Design: Experimental study with a pre- and post-test. Setting: In Vitro Fertilization Center Patients: Its sample consisted of 118 women, 58 in the experimental group and 60 in the control group. Intervention(s): At the beginning of the infertility treatment, the experimental group took vitamin D supplements, and the control group did not. Vitamin D supplementation for infertile women includes regulation of a diet rich in vitamin D, educational and motivational interviews about insolation, and taking vitamin D orally. Main Outcome Measure(s): 25(OH)D and beta HCG levels

vitamin D, vitamin D supplementation, infertility, D vitamin deficiency, infertile women, embryo transfer, pregnancy rate

The physicians gave the women in the experimental group vitamin D oral drops in an ampoule of 300,000 IU and a vial of 50,000 IU to take during the IVF treatment. Written and verbal information about how to take vitamin D was provided to the participants by the nurses. The women took 300,000 IU vitamin D orally for the first week. In the second week of the treatment, 50,000 IU vitamin D (15 drops/day) was used as maintenance dose until the pregnancy test day.

The 25 (OH)D levels of the experimental group women were tested on the second or third day of their menstrual cycle. (Pretest)

Inclusion Criteria: 18-45 years old literate in Turkish voluntary participation primarily infertile had undergone controlled ovarian hyperstimulation and had a fresh ET vitamin D levels lower than 30ng/mL before infertility treatment Exclusion Criteria: patients with uncorrected congenital or acquired uterine anomalies bone, parathyroid gland, kidney and liver disorders use of anticonvulsants/antacid drugs taking dietary supplements contain vitamin D secondary infertility