The Effect of Zoledronic Acid on Bone Loss in Prostate Cancer Patients Undergoing Androgen Deprivation Therapy
Prostate Cancer
About this trial
This is an interventional prevention trial for Prostate Cancer focused on measuring Prostate Cancer, Bone Loss, Osteoporosis, Bone Mineral Density, Androgen Deprivation Therapy
Eligibility Criteria
Histologically confirmed diagnosis of carcinoma of the prostate No distant metastases (stage TNMO) (ie. prostate cancer without metastases) Patients within one year at the day of randomization from initiation of androgen deprivation therapy with a LHRH agonist (with or without an antiandrogen) and with the intended duration of androgen deprivation therapy of at least 12 months. Patients may also enter if they have received an orchiectomy (or"ke-ek'te-me) within two weeks of visit 1 Patients who received any prior bisphosphonate therapy in the past 12 months will be excluded Patients who are currently receiving diethylstilbesterol (DES) or PC-SPES (treatment for osteoporosis) will be excluded Patients who have received prior treatment with systemic corticosteroids within the past 12 months will be excluded (short term corticosteroid therapy, e.g. to prevent/treat chemotherapy-induced nausea/vomiting or for acute illness like asthma exacerbation, is acceptable) Other eligibility criteria may apply
Sites / Locations
- Millennium Therapeutics & Research
- Medical Affiliated Research Center
- Alaska Clinical Research Center
- Advanced Clinical Therapeutics
- Donald Gleason, MD
- Arkansas Urology
- Advanced Urology Med. Center
- Atlantic Urological Medical Group
- San Diego Uro. Research
- Western Clinical Research
- Connecticut Surgical Group
- Grove Hill Urology
- Atlantic Urological Associates
- University of Miami School of Medicine, Dept. of Urology
- Advanced Research Institute, Inc.
- Urosearch
- Southeastern Urological Center, PA
- Medisphere Medical Research Center, LLC
- The Iowa Clinic, PC, Iowa Urology Research
- Summitt Clinical Research
- Millennium Medical Center
- Quality Clinical Research LLC
- Associated Urologic Specialist, PA
- Morristown Memorial Hospital
- Associates In Urology, LLC
- AccuMed Research Associates
- Urological Surgeons of L.I.
- Staten Island Urological Research, PC
- The Urology Group
- Urological Associates, Inc.
- Mount Vernon Urological Associates
- Oregon Urology Specialists
- The Urology Clinic
- Urologic Associates of Allentown
- Albert Einstein Medical Center
- Triangle Urological Group
- Urologic Surgeons of New England, P.C.
- University Urological Research Institute
- Carolina Urologic Research Center
- Integrity Clinical Research, LLC
- Urology San Antonio Research
- Salt Lake Research
- Seattle Urological Associates
- Rockwood Clinic