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The Effects of a Jump Rope Exercise Program on Vascular Health, Inflammatory Markers in Prehypertensive Adolescent Girls

Primary Purpose

Prehypertension, Blood Pressure, Abdominal Obesity

Status
Completed
Phase
Not Applicable
Locations
Study Type
Interventional
Intervention
Jump rope exercise intervention
Sponsored by
Pusan National University
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional health services research trial for Prehypertension focused on measuring arterial stiffness, endothelin-1, c-reactive protein, adiposity, exercise, jump rope

Eligibility Criteria

14 Years - 16 Years (Child)FemaleAccepts Healthy Volunteers

Inclusion Criteria:

  • prehypertensive
  • sedentary (no regular exercise training or physical activity within the last year)
  • no weight loss diet during the last six months

Exclusion Criteria:

  • pregnancy
  • chronic disease
  • daily medication use (including antioxidants and weight loss supplements)

Sites / Locations

    Arms of the Study

    Arm 1

    Arm 2

    Arm Type

    No Intervention

    Experimental

    Arm Label

    Control group

    Jump rope exercise intervention

    Arm Description

    No exercise intervention

    The jump rope exercise program was performed for 50 minutes with 5 minutes of warm-up and cool-down per day, 5 times a week for 12 weeks. The program consisted of various main jump rope exercises (1 line 2 jump, jumping feet together, running jumping, open side jump, open back and forth jump, rock paper scissor jump). The warm-up and cool down consisted of static stretching, walking, and jogging. Intensity of exercise was gradually increased from 40-50% heart rate reserve (HRR) in weeks 1-4 and to 60-70% HRR in weeks 9-12. Each training session was supervised by the researchers. Every subject wore a heart rate monitor during the whole training session in order to maintain the designated training intensity.

    Outcomes

    Primary Outcome Measures

    Arterial Stiffness
    Arterial stiffness was measured as measurement of brachial to ankle pulse-wave velocity. This indicates peripheral arterial stiffness, as it measures how quickly a pulse wave propagates from one point to another.
    Endothelin-1
    Levels of Endothelin-1 in blood were measured by Endothelin-1 enzyme immunoassay kit.
    Body Mass
    Body mass was measured to nearest 0.1 kg.
    Height
    Height was measured to nearest 1 cm.
    Waist Circumference
    Waist circumference was measured at midpoint between the lower rib and the iliac crest at the end of a normal expiration using a tape measure.
    Body Fat
    Percent body fat (%) was determined using a bioelectrical impedance-meter.
    Lean Body Mass
    Lean body mass (kg) was determined using a bioelectrical impedance-meter.
    Nitrate/Nitrite Levels
    Nitrate and nitrite levels were assayed using a Griess assay kit.
    C-reactive Protein
    C-reactive protein was assessed using an enzyme immunoassay assay kit
    Systolic Blood Pressure
    Blood pressure was measured in duplicate using an automated sphygmomanometer. The average of the two was recorded as the resting blood pressure.
    Diastolic Blood Pressure

    Secondary Outcome Measures

    Full Information

    First Posted
    May 11, 2018
    Last Updated
    October 27, 2020
    Sponsor
    Pusan National University
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    1. Study Identification

    Unique Protocol Identification Number
    NCT03534427
    Brief Title
    The Effects of a Jump Rope Exercise Program on Vascular Health, Inflammatory Markers in Prehypertensive Adolescent Girls
    Official Title
    The Effects of a 12-Week Jump Rope Exercise Training Program on Arterial Stiffness, Vasodilating and Vasoconstricting Factors, Inflammatory Markers, and Body Composition in Prehypertensive Adolescent Girls
    Study Type
    Interventional

    2. Study Status

    Record Verification Date
    October 2020
    Overall Recruitment Status
    Completed
    Study Start Date
    June 5, 2011 (Actual)
    Primary Completion Date
    February 10, 2012 (Actual)
    Study Completion Date
    March 21, 2012 (Actual)

    3. Sponsor/Collaborators

    Responsible Party, by Official Title
    Principal Investigator
    Name of the Sponsor
    Pusan National University

    4. Oversight

    Studies a U.S. FDA-regulated Drug Product
    No
    Studies a U.S. FDA-regulated Device Product
    No

    5. Study Description

    Brief Summary
    The purpose of this study was to examine the impact of a 12-week jump rope exercise program on blood pressure, arterial stiffness, vasodilating and vasoconstricting factors, inflammatory markers, and body composition in prehypertensive adolescent girls. Forty prehypertensive adolescent girls participated in this study. The girls were randomly divided into the jump rope exercise intervention group (EX, n=20) and control group (CON, n=20). The EX group performed a jump rope training program at 40-70% of their heart rate reserve (HRR) 5 days/week for 12 weeks (sessions 50 minutes in duration). The CON group did not participate in any structured or unstructured exercise protocol. Blood pressure, arterial stiffness, plasma nitrate/nitrite levels, endothelin-1, C-reactive protein, and body composition were measured before and after the 12-weeks study.

    6. Conditions and Keywords

    Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
    Prehypertension, Blood Pressure, Abdominal Obesity, Adiposity
    Keywords
    arterial stiffness, endothelin-1, c-reactive protein, adiposity, exercise, jump rope

    7. Study Design

    Primary Purpose
    Health Services Research
    Study Phase
    Not Applicable
    Interventional Study Model
    Parallel Assignment
    Model Description
    exercise intervention group, control group
    Masking
    None (Open Label)
    Allocation
    Randomized
    Enrollment
    40 (Actual)

    8. Arms, Groups, and Interventions

    Arm Title
    Control group
    Arm Type
    No Intervention
    Arm Description
    No exercise intervention
    Arm Title
    Jump rope exercise intervention
    Arm Type
    Experimental
    Arm Description
    The jump rope exercise program was performed for 50 minutes with 5 minutes of warm-up and cool-down per day, 5 times a week for 12 weeks. The program consisted of various main jump rope exercises (1 line 2 jump, jumping feet together, running jumping, open side jump, open back and forth jump, rock paper scissor jump). The warm-up and cool down consisted of static stretching, walking, and jogging. Intensity of exercise was gradually increased from 40-50% heart rate reserve (HRR) in weeks 1-4 and to 60-70% HRR in weeks 9-12. Each training session was supervised by the researchers. Every subject wore a heart rate monitor during the whole training session in order to maintain the designated training intensity.
    Intervention Type
    Other
    Intervention Name(s)
    Jump rope exercise intervention
    Intervention Description
    12-week jump rope exercise program
    Primary Outcome Measure Information:
    Title
    Arterial Stiffness
    Description
    Arterial stiffness was measured as measurement of brachial to ankle pulse-wave velocity. This indicates peripheral arterial stiffness, as it measures how quickly a pulse wave propagates from one point to another.
    Time Frame
    12 weeks
    Title
    Endothelin-1
    Description
    Levels of Endothelin-1 in blood were measured by Endothelin-1 enzyme immunoassay kit.
    Time Frame
    12 weeks
    Title
    Body Mass
    Description
    Body mass was measured to nearest 0.1 kg.
    Time Frame
    12 weeks
    Title
    Height
    Description
    Height was measured to nearest 1 cm.
    Time Frame
    12 weeks
    Title
    Waist Circumference
    Description
    Waist circumference was measured at midpoint between the lower rib and the iliac crest at the end of a normal expiration using a tape measure.
    Time Frame
    12 weeks
    Title
    Body Fat
    Description
    Percent body fat (%) was determined using a bioelectrical impedance-meter.
    Time Frame
    12 weeks
    Title
    Lean Body Mass
    Description
    Lean body mass (kg) was determined using a bioelectrical impedance-meter.
    Time Frame
    12 weeks
    Title
    Nitrate/Nitrite Levels
    Description
    Nitrate and nitrite levels were assayed using a Griess assay kit.
    Time Frame
    12 weeks
    Title
    C-reactive Protein
    Description
    C-reactive protein was assessed using an enzyme immunoassay assay kit
    Time Frame
    12 weeks
    Title
    Systolic Blood Pressure
    Description
    Blood pressure was measured in duplicate using an automated sphygmomanometer. The average of the two was recorded as the resting blood pressure.
    Time Frame
    12 weeks
    Title
    Diastolic Blood Pressure
    Time Frame
    12 weeks

    10. Eligibility

    Sex
    Female
    Gender Based
    Yes
    Minimum Age & Unit of Time
    14 Years
    Maximum Age & Unit of Time
    16 Years
    Accepts Healthy Volunteers
    Accepts Healthy Volunteers
    Eligibility Criteria
    Inclusion Criteria: prehypertensive sedentary (no regular exercise training or physical activity within the last year) no weight loss diet during the last six months Exclusion Criteria: pregnancy chronic disease daily medication use (including antioxidants and weight loss supplements)

    12. IPD Sharing Statement

    Plan to Share IPD
    No

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    The Effects of a Jump Rope Exercise Program on Vascular Health, Inflammatory Markers in Prehypertensive Adolescent Girls

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