The Effects of Equivalent Weight Loss With or Without Exercise Training on Breast Cancer Risk (SHAPE-2) (SHAPE-2)
Breast Cancer Risk
About this trial
This is an interventional basic science trial for Breast Cancer Risk focused on measuring Breast cancer, Sex hormones, Physical activity
Eligibility Criteria
Inclusion Criteria:
- Female
- 50-69 years of age
- Postmenopausal (>12 months after last menses)
- BMI 25-35 kg/m2
- Sedentary (<2 hours per week of at least moderately intensive activities (>4 MET))
- Willing to be randomly assigned to one of the three study arms
- Informed consent to participate in all screening and study activities.
Exclusion Criteria:
Presently using sex-hormones
- Maintenance use of corticosteroids
- Suffering cancer (in medical history) except for non-melanoma skin cancers
- Suffering type II diabetes mellitus or other endocrine related diseases
- Smoking
- Alcohol or drug abuse
- Any disorder that might impede participation in the exercise programme
- Following, or the intention to follow, a structured weight loss programme elsewhere
Sites / Locations
- Medisch Spectrum Twente
- UMC Utrecht
Arms of the Study
Arm 1
Arm 2
Arm 3
Experimental
Experimental
No Intervention
Diet-induced weight loss
Mainly exercise induced weight loss
Control, stable weight
The diet-induced weight loss group will follow a calorie restricted diet. They are asked to keep their habitual sedentary lifestyle. The aim of this group is to loose 5-6 kg of body weight in 14 weeks time.
Participants in the exercise- plus diet-induced weight loss group are enrolled in an exercise programme. Next to the exercise programme, they will follow a calorie restricted diet. The aim of this group is to loose 5-6 kg of body weight in 14 weeks time.
The control group is asked to follow a baseline isocaloric diet and to not change their habitual sedentary lifestyle.