The Effects of Glucocorticoids on Mortality and Renal Function in Patients With Acute Decompensated Heart Failure
Heart Failure
About this trial
This is an interventional treatment trial for Heart Failure focused on measuring heart failure, prednisone, cardiovascular mortality, renal function
Eligibility Criteria
Inclusion Criteria:
Patients with dyspnea at rest due to acutely decompensated CHF requiring hospitalization and intravenous therapy. The cardiac etiology for acutely decompensated CHF was established by echocardiogram and/or a chest x-ray film and 2 of the following:
- >2-pillow orthopnea before study entry
- Jugular venous distention and/or abdominal discomfort due to mesenteric congestion.
Patients may have had acute decompensation of chronic heart failure, gradual worsening of chronic heart failure, or new onset of acutely decompensated CHF. Patients who were receiving intravenous therapy i.e. Inotropic and/or vasodilator but who otherwise met entry criteria were also permitted into the study. Patients with signs of cardiac shock were also permitted into the study.
Exclusion Criteria:
- Patient refusal
- Any signs of infection
- any condition that would contraindicate a glucocorticoids use
- Poor controlled hypertension
- Poor controlled diabetes mellitus
- Active myocarditis
- Malignancy or other terminal illness
Sites / Locations
- The First Hospital of Hebei Medical University
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
glucocorticoid
Standard care