the Effects of GnRHa Add up to Routine Luteal Phase Support on Frozen Embryo Implantation in Frozen Embryo Transfer .
Infertility
About this trial
This is an interventional treatment trial for Infertility focused on measuring Frozen embryo transfer,luteal support, GnRHa
Eligibility Criteria
Inclusion Criteria:
- infertile women with frozen thawed embryo transfer after HRT endometrial preparation.
- more than 20 years old, and less than 37 years old.
- BMI less than 28kg/m2.
- more than 1 transplantable embryo after thawing.
- patients should sign the informed consent and have the willing to follow up.
Exclusion Criteria:
- uterine malformation
- diameter of intramural myoma more than 3cm
- the thickness of endometrium less than 7mm on the progesterone supportive day.
Sites / Locations
- Chong Qing Reproductive and Genetic InstituteRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Other
GnRHa protocol
routine luteal phase protocol
All subjects are artificially preparing endometrium starting on day 3-5 of the cycle with oral E2 (Progynova) 4-10mg/day at least 14 days. After ultrasound and hormone tests, progesterone 100mg/day intramuscular injection is allocated with E2.In the meanwhile, if the subjects have a fail history of hormonal artificially preparing endometrium, such as an early ovulation, a singal dose of triptorelin 3.75mg would be intramuscular injected before E2 was used as a pretreatment. Then a maximum of two embryos are transferred when endometrium is perfectly prepared. All subjects receive routine luteal phase support with E2 and progesterone .A single dose of Triptorelin 0.1mg is administrated on the 3rd day after embryo implanted with routine luteal phase support.
All subjects are artificially preparing endometrium starting on day 3-5 of the cycle with oral E2 4-10mg/day at least 14 days. After ultrasound and hormone tests, progesterone 100mg/day intramuscular injection is allocated with E2. In the meanwhile, if the subjects have a fail history of hormonal artificially preparing endometrium, such as an early ovulation, a singal dose of triptorelin 3.75mg would be intramuscular injected before E2 was used as a pretreatment. Then a maximum of two embryos are transferred when endometrium is perfectly prepared. All subjects receive routine luteal phase support with E2 and progesterone .