The Effects of Prednisone on HIV Levels and the Immune System
HIV Infections
About this trial
This is an interventional treatment trial for HIV Infections focused on measuring Drug Therapy, Combination, Prednisone, Anti-HIV Agents
Eligibility Criteria
Inclusion Criteria You may be eligible for this study if you: Are HIV-positive. Have a CD4 cell count of 200-600 cells/mm3 within 30 days of study entry. (This study has been changed. You now must have a CD4 cell count of 200-700 cells/mm3 within 45 days of study entry.) Have had your viral load measured within 30 days of study entry. Have been on stable anti-HIV therapy with at least two anti-HIV agents for at least 12 weeks, and you intend to remain on this therapy during the study. Are at least 18 years of age. Agree to abstain from sex or use effective methods of birth control during the study and for 30 days after. Exclusion Criteria You will not be eligible for this study if you: Abuse alcohol or drugs or have a serious psychological condition. Are allergic to prednisone or other corticosteroids. Have a history of opportunistic (AIDS-related) infections, including cytomegalovirus (CMV), Mycobacterium avium complex (MAC), or Kaposi's sarcoma (KS). Have a history of a serious medical condition, including heart problems, tuberculosis (TB), cancer, diabetes, or osteoporosis. Are being treated for herpes at study entry. Have received certain medications, including blood pressure medication. Are pregnant or breast-feeding.
Sites / Locations
- Univ of Alabama at Birmingham
- Univ of Southern California / LA County USC Med Ctr
- Queens Med Ctr
- Univ of Hawaii / Leahi Hosp
- Univ of Hawaii
- Northwestern Univ Med School
- Cook County Hosp
- Rush Presbyterian - Saint Luke's Med Ctr
- Indiana Univ Hosp
- Harvard (Massachusetts Gen Hosp)
- Univ of Minnesota
- Bellevue Hosp / New York Univ Med Ctr
- Mount Sinai Med Ctr
- Case Western Reserve Univ
- MetroHealth Med Ctr
- Ohio State Univ Hosp Clinic
- Milton S Hershey Med Ctr
- Univ of Washington