Back to resultsThe Effects of Prolonged Standing Compared to Prolonged Sitting on Postprandial Lipemia
Primary Purpose
Metabolic Syndrome, Atherosclerosis
Status
Completed
Phase
Not Applicable
Locations
United States
Study Type
Interventional
Intervention
Prolonged Standing
Prolonged Sitting
Sponsored by
About this trial
This is an interventional prevention trial for Metabolic Syndrome
Eligibility Criteria
Inclusion Criteria:
-
Exclusion Criteria:
- heart problems
- coronary artery disease
- hypertension
- respiratory problems
- musculoskeletal problems that prevent prolonged standing or sitting
- obesity
- susceptibility to fainting
Sites / Locations
- University of Texas at Austin Human Performance Laboratory
Arms of the Study
Arm 1
Arm 2
Arm Type
Experimental
Experimental
Arm Label
Prolonged Standing
Prolonged Sitting
Arm Description
Subject stand for 12 hours. The following day the subject will undergo a high fat tolerance test. Order of sitting/standing will be random and each subject will perform both interventions.
Subject sit for 12 hours. The following day the subject will undergo a high fat tolerance test. Order of sitting/standing will be random and each subject will perform both interventions.
Outcomes
Primary Outcome Measures
Plasma Triglycerides
The area under the curve for plasma triglycerides from hourly samples during a 6 hour high fat tolerance test
Plasma Insulin
The area under the curve for plasma insulin from hourly samples during a 6 hour high fat tolerance test
Plasma Glucose
The area under the curve for plasma glucose from hourly samples during a 6 hour high fat tolerance test
Secondary Outcome Measures
Full Information
NCT ID
NCT03089437
First Posted
March 20, 2017
Last Updated
October 3, 2018
Sponsor
University of Texas at Austin
1. Study Identification
Unique Protocol Identification Number
NCT03089437
Brief Title
The Effects of Prolonged Standing Compared to Prolonged Sitting on Postprandial Lipemia
Official Title
The Effects of Prolonged Standing Compared to Prolonged Sitting on Postprandial Lipemia
Study Type
Interventional
2. Study Status
Record Verification Date
October 2018
Overall Recruitment Status
Completed
Study Start Date
March 31, 2017 (Actual)
Primary Completion Date
August 11, 2017 (Actual)
Study Completion Date
August 11, 2018 (Actual)
3. Sponsor/Collaborators
Responsible Party, by Official Title
Principal Investigator
Name of the Sponsor
University of Texas at Austin
4. Oversight
Studies a U.S. FDA-regulated Drug Product
No
Studies a U.S. FDA-regulated Device Product
No
Data Monitoring Committee
No
5. Study Description
Brief Summary
The effects of 12 hours of prolonged standing will be compared to prolonged standing on a high fat tolerance test the following day. Plasma triglycerides, insulin, and glucose will be measured in a crossover study design.
6. Conditions and Keywords
Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Metabolic Syndrome, Atherosclerosis
7. Study Design
Primary Purpose
Prevention
Study Phase
Not Applicable
Interventional Study Model
Crossover Assignment
Masking
None (Open Label)
Allocation
Randomized
Enrollment
12 (Actual)
8. Arms, Groups, and Interventions
Arm Title
Prolonged Standing
Arm Type
Experimental
Arm Description
Subject stand for 12 hours. The following day the subject will undergo a high fat tolerance test. Order of sitting/standing will be random and each subject will perform both interventions.
Arm Title
Prolonged Sitting
Arm Type
Experimental
Arm Description
Subject sit for 12 hours. The following day the subject will undergo a high fat tolerance test. Order of sitting/standing will be random and each subject will perform both interventions.
Intervention Type
Behavioral
Intervention Name(s)
Prolonged Standing
Intervention Description
Subject will stand for 12 hours and undergo a high fat tolerance test the subsequent day
Intervention Type
Behavioral
Intervention Name(s)
Prolonged Sitting
Intervention Description
Subject will sit for 12 hours and undergo a high fat tolerance test the subsequent day
Primary Outcome Measure Information:
Title
Plasma Triglycerides
Description
The area under the curve for plasma triglycerides from hourly samples during a 6 hour high fat tolerance test
Time Frame
6 hours
Title
Plasma Insulin
Description
The area under the curve for plasma insulin from hourly samples during a 6 hour high fat tolerance test
Time Frame
6 hours
Title
Plasma Glucose
Description
The area under the curve for plasma glucose from hourly samples during a 6 hour high fat tolerance test
Time Frame
6 hours
10. Eligibility
Sex
All
Minimum Age & Unit of Time
18 Years
Maximum Age & Unit of Time
40 Years
Accepts Healthy Volunteers
Accepts Healthy Volunteers
Eligibility Criteria
Inclusion Criteria:
-
Exclusion Criteria:
heart problems
coronary artery disease
hypertension
respiratory problems
musculoskeletal problems that prevent prolonged standing or sitting
obesity
susceptibility to fainting
Facility Information:
Facility Name
University of Texas at Austin Human Performance Laboratory
City
Austin
State/Province
Texas
ZIP/Postal Code
78712
Country
United States
12. IPD Sharing Statement
Plan to Share IPD
No
Learn more about this trial
The Effects of Prolonged Standing Compared to Prolonged Sitting on Postprandial Lipemia
We'll reach out to this number within 24 hrs