The Efficacy of Continuous Positive Airway Pressure in Achieving Asthma Control in Patients With Severe Asthma and Obstructive Sleep Apnea
Severe Asthma With Obstructive Sleep Apnea
About this trial
This is an interventional treatment trial for Severe Asthma With Obstructive Sleep Apnea
Eligibility Criteria
Inclusion Criteria:
The diagnosis of asthma and the classification of disease severity will be established according to the Global Initiative for Asthma (GINA) criteria. Asthma diagnosis is based either on spirometry that shows an obstructive airway defect with reversibility that has been defined as a minimum of 12% increase in the post-bronchodilator forced expiratory volume in 1 s (FEV1) and >200 mL of the FEV1, or subjects with physician-diagnosed asthma.
- Severe Asthma (defined as being on step 4 or 5 of treatment as per GINA guidelines 2019)
- All patients should not change their controller therapy for at least eight weeks before enrollment to participate in the study.
- All patients should be naïve to CPAP.
Exclusion Criteria:
- Mild or Moderate asthma according on GINA 2019
- Patients with cardiac diseases, other lung diseases (Such as COPD and restrictive lung disease), cognitive impairment that could limit the comprehension or collaboration of the subject in the study, or any severe decompensated comorbid disease
- Patients with acute asthma exacerbation within 4 weeks of recruitment
- Pregnancy
- Smoker
Sites / Locations
- King Abdulaziz University HospitalRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Active Comparator
No Intervention
No Intervention
Asthma with Obstructive Sleep Apnea on treatment
Asthma with Obstructive Sleep Apnea whom refused treatment
Asthma without Obstructive Sleep Apnea
Over the following 6 months of recruiting the study population with severe asthma the following will be monitored EVERY MONTH: Level of asthma control: Asthma Control Test/GINA guidelines Excessive Daytime Sleepiness using Epworth Sleepiness Scale. Rate of exacerbations/hospitalization Continuous Positive Airway Pressure (CPAP) compliance: where acceptable compliance is defined as minimum of CPAP use of >/= 4 hrs/70% nights (if applicable), In one month, 3month, 6 month duration Apnea/Hypopnea Index as per CPAP reading (if applicable)
Over the following 6 months of recruiting the study population with severe asthma the following will be monitored EVERY MONTH: Level of asthma control: Asthma Control Test/GINA guidelines Excessive Daytime Sleepiness using Epworth Sleepiness Scale. Rate of exacerbations/hospitalization
Over the following 6 months of recruiting the study population with severe asthma the following will be monitored EVERY MONTH: Level of asthma control: Asthma Control Test/GINA guidelines Excessive Daytime Sleepiness using Epworth Sleepiness Scale. Rate of exacerbations/hospitalization