The Efficacy of Escitalopram for Negative Symptoms in Schizophrenia

Inclusion Criteria: Chronic schizophrenia patients, Age <60, Medicated, Inpatients and outpatients,on stable doses of antipsychotic medications for at least one month before the study entry. Patients will be clinically stable and free of any additional axis I diagnosis or significant medical illnesses before enrollment into the study. A Positive and Negative Syndrome Scale (PANSS) score of 50 or above will be required for entry to the study. Exclusion Criteria: Comorbidity with mania or major depression, Pregnancy, Lactation, Impaired renal or hepatic function, History of sensitivity to cipramil or to other drugs from the selective serotonin reuptake inhibitor (SSRI) group. Additional exclusion criteria will consist of mental retardation, organic conditions (brain tumors, drug abuse) and severe exacerbation of the psychiatric condition (i.e. suicide attempt, severe psychotic exacerbation) as defined by hospitalization in high-security units, clinical impression and CGI scores of "condition much worsened". Patients will be excluded during the study if they will remove their informed consent.