The Efficacy of Pre-procedural Mouth Rinses on COVID-19 Saliva Viral Load
SARS-CoV-2, COVID-19, Mouthwashes
About this trial
This is an interventional prevention trial for SARS-CoV-2
Eligibility Criteria
Inclusion Criteria:
- Adults age 18 years or older presented to TETAMMAN clinics, Jeddah, Saudi Arabia.
- COVID-19-positive patients confirmed by RT-PCR and within two days of oral or nasopharyngeal swabs
- Asymptomatic or within seven days of the onset of symptoms.
- Has the ability to rinse and expectorate.
Exclusion Criteria:
- Participants who established antiviral, corticosteroid, antimicrobial, or immunosuppressive medications.
- Known allergy to one of the constituents of the mouth rinse
- Thyroid disease or on current radioactive iodine treatment
- Pregnant or breastfeeding women
- Lithium therapy
- History of radiotherapy or chemotherapy
- Use of mouthwash before presented to TETAMMAN clinics
Sites / Locations
- Alhamra TETAMMAN clinic (PHC)
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Arm 5
Arm 6
Placebo Comparator
Active Comparator
Active Comparator
Active Comparator
Active Comparator
Placebo Comparator
Distilled Water
Povidone Iodine (PVP-I)
Hydrogen Peroxide (H2O2)
Cetylpyridinium Chloride (CPC)
Sodium Hypochlorite
No rinse group
Vigorously rinse with 15 ml of the distilled water for 30 s (Water for Injections BP; Pharmaceutical Solutions Industry, Jeddah, SA)
Vigorously rinse with 15 ml of the 1% povidone-iodine (PVP-I) (Betadine Mouthwash/Gargle; Avrio Health LP, Stamford, CT, USA) for 30 s
Vigorously rinse with 15 ml of the 1.5% hydrogen peroxide (H2O2) (Peroxyl; Colgate-Palmolive, Guildford, UK) for 30 s
Vigorously rinse with 15 ml of the 0.075% cetylpyridinium chloride (CPC) (Colgate Total; Colgate-Palmolive, Guildford, UK) for 30 s
Vigorously rinse with 15 ml of the 80 ppm sodium hypochlorite (NaOCl) (Clinisept Dental Mouthwash; Clinical Health Technologies, Hinckley, Leicestershire, UK) for 30 s
There is no mouth rinse in this group. Patients will collect the saliva at all 4-time points without gargling with the mouth rinse.