The Evaluation of Postoperative Antibiotics in Non-Infected Mandible Fractures
Jaw Fractures, Infection
About this trial
This is an interventional treatment trial for Jaw Fractures focused on measuring Infection, Jaw fracture
Eligibility Criteria
Inclusion Criteria:
- All mandible fracture patients planned for Open Reduction and Internal Fixation (ORIF)
Exclusion Criteria:
- Age - < 18 years
- Pregnancy
- Fracture Site - closed / non-dentate eg. Condylar neck, edentulous
- Soft Tissue Injury - > Grade 4 (GSW)
- Allergic to all study drugs
Medical Problems
- Diabetes - Hb A1C > 10
- Immunologic compromise
- On Chemotherapy
- Interval - Injury to Surgery - > 10days
Already receiving antibiotics for
- Another wound eg. Open fracture prophylaxis
- Documented / suspected infection
- Inability to provide informed consent.
Sites / Locations
- Memorial Hermann HospitalRecruiting
- Th University of Texas Health Science Center at HoustonRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
Treatment
Control
Trial groups will receive a single post-operative dose administration of Unasyn 3g or Clindamycin 600mg (for penicillin allergies), then the patients in the trial group will be switched to oral Augmentin 875mg twice a day for 7 days (Amoxicillin and Clavulanic acid which is clinically interchangeable with Unasyn), or oral Clindamycin 150mg to 300mg four times a day for 7 days (for penicillin allergies). If the patient is discharged home prior to completing 7 days of oral antibiotic therapy, patient will receive prescription to finish the remaining doses of antibiotics for a total period of 7 days.
Control group will not receive any postoperative antibiotics other than what is accepted as preoperative prophylactic antibiotics as per current standards of care.