The Impact of Interferon Beta 1a on Egyptian Relapse-Remitting Multiple Sclerosis Patients

Our study aimed to investigate the effect of interferon beta 1a on the clinical and immunological parameters in Egyptian relapse-remitting multiple sclerosis patients

Until recently, relapsing-remitting multiple sclerosis (RRMS) was considered a homogeneous form of multiple sclerosis (MS). Variability both in the immunopathology of active demyelinating lesions in MS and in response to immunomodulatory treatments has demonstrated that RRMS is a heterogeneous form of MS. An overwhelming number of trials have supported the use of interferon-β (IFN-β) as a first-line immunomodulatory treatment in RRMS. Approximately 30% of IFN-β treated RRMS patients are non-responders (NR) to treatment. Despite vast clinical experience in the use of IFN-β, its mechanisms of action have not been fully clarified. Interleukin-17 (IL-17) is a proinflammatory cytokine that is secreted by a lineage of T cells named Th17 cells. The Th17 chemokine pathways are essential for the development of central nervous system (CNS) autoimmune diseases such as MS. A high IL-17 concentration in the serum. of people with RRMS is associated with nonresponse to IFN-β therapy. Some animal and human studies have shown that IFN-β inhibits the activity of Th17 cells.

Determination disability level (0 - 6), The lowest value means that it is best outcome and the highest value is the worst outcome.

Inclusion Criteria: Age between 18 and 50 years at time of signing informed consent form. Relapsing- remitting multiple sclerosis as per the McDonald 2017 criteria, including an MRI brain satisfying the 2017 radiological criteria. Full-field visual evoked potential (VEP) P100 latency in at least one eye of ≥118 ms. Kurtzke EDSS step 0.0 - 6.0. At the time of screening, being treated with a stable dose for at least 6 months of a category 1 multiple sclerosis DMT or for at least 2 years with a category 2 DMT. Exclusion Criteria: they had been treated in the last 30 days with methylprednisolone they had changed their IFN-β preparation within the last 18 months they had other chronic diseases associated with MS they had been previously treated with immunosuppressive agents

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