The Impact of Psychological Interventions on Psychometric and Immunological Measures in Patients With Major Depression
Depression
About this trial
This is an interventional treatment trial for Depression focused on measuring Depression, Exercise, Psychoneuroimmunology, Cognitive Behavioral Therapy, CBASP
Eligibility Criteria
Inclusion Criteria:
- patients with Major Depression (DSM IV), BDI >=18
- age:18-65 years
- patients with and without antidepressive medication
- comorbidity with other psychiatric disorders is permitted, as far as depressive symptoms are dominating
Exclusion Criteria:
- current psychotherapy
- psychotic disorder
- serious drug-addiction
- drugs which seriously affect immune status (except contraceptives) or central nervous system functions (except antidepressants)
- infections during the last 2 weeks
- injuries during the last 2 weeks
- neurological disorders
- diseases which affect immune status or central nervous system functions (e.g. rheumatoid arthritis, CVD,etc.)
Sites / Locations
- Department of Clinical Psychology and Psychotherapy, Philipps University Marburg
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Experimental
Active Comparator
Active Comparator
No Intervention
CBT-active
CBT-euthymic
CBASP
Waiting List
Patients with Major Depression (N = 50) get a common CBT treatment in combination with physical exercise.
Patients with Major Depression (N = 50) get the same common CBT treatment as the CBT-active-group, but instead of physical exercise they receive an enjoyment training, which is based on exercises from the "Kleine Schule des Genießens" (Koppenhöfer, 2004)
Patients with Major Depression (N=50) get a cognitive therapy according to the Cognitive Behavioral Analysis System of Psychotherapy (CBASP).
Patients randomized to the waiting list receive psychological treatment after waiting for 4 month.