The IMPULSE Study: Pilot (IMPULSE)
Chronic Heart Failure
About this trial
This is an interventional prevention trial for Chronic Heart Failure focused on measuring left ventricular assist device, continuous flow, remote ischemic conditioning, hypertension, sympathetic tone, endothelial dysfunction
Eligibility Criteria
Inclusion Criteria:
- continuous flow LVAD and able to provide informed consent and comply with follow-up
Exclusion Criteria:
- < 18 years of age
Sites / Locations
- Baylor College of Medicine
Arms of the Study
Arm 1
Arm 2
Experimental
No Intervention
Intervention
Control
Our intervention will be ischemic conditioning (IC) remotely applied using a sphygmomanometer. We will use the standard, validated protocol, which is inflation of the sphygmomanometer to 200 mmHg for 5 minutes, then deflation with 5 minutes of reperfusion, repeated for 3 cycles (total 30 minutes). This will be done in the dominant arm, twice daily. Once patients are discharged home on a stable pharmacotherapy regimen, they will be expected to follow the above intervention for 6 weeks, followed by another 6 weeks in the control (no intervention) phase. Patients will be randomized as to which phase they begin the study.
standard care