The Interaction Between Calcium and Vitamin D Intake (PTH Modified)

This is an interventional prevention trial for Osteoporosis focused on measuring Bone resorption, Calcium homeostasis, Bone markers, Calcium and Vitamin D supplementation, Parathyroid hormone levels, Interaction between calcium and vitamin D supplementation Read More

Inclusion Criteria:

• Healthy women aged 45 and above who have been menopausal at least 1 year (absence of menstrual period for a period of 12 months or more)

Exclusion Criteria:

• Any chronic medical illness including uncontrolled diabetes mellitus, recent history of myocardial infarction, or heart failure, malignancy, uncontrolled hypertension, obesity (BMI>35 kg/m2), history of anemia, leukemia, or other hematologic abnormalities, lupus, rheumatoid arthritis, or other rheumatologic disease, or kidney disease of any kind as determined by history and physical examination.
• Subjects with osteoporosis of the hip (total hip T-score equal or less than -2.5) or taking medications for osteoporosis such as bisphosphonates will be excluded.
• Pregnancy.
• Use of medication that influences bone metabolism (i.e. anticonvulsant medications, chronic use of steroids and high dose diuretics).
• Significant deviation from normal in medical history, physical examination, or laboratory tests as evaluated by the primary investigator.
• Patients with a history of hypercalciuria, hypercalcemia, nephrolithiasis, and active sarcoidosis will also be excluded.
• Participation in another investigational trial in the past 30 days prior to the screening evaluation.
• Unexplained weight loss of >15% during the previous year or history of anorexia nervosa.
• Medications that interfere with vitamin D metabolism.
• Patients with a habitual dietary calcium intake that exceeds 800 mg/day.
• Smokers greater than 1 pack per day will be excluded.
• Patients reporting alcohol intake greater than 2 drinks daily.
• Serum 25-hydroxyvitamin D level > 75 nmol/L.