The Learning Effects of Task-priority Strategy on Dual-task Weight Shifting and Brain Plasticity in Patients With Parkinson's Disease
Primary Purpose
Postural and Suprapostural Performance During Dual Tasking in Patients With Parkinson's Disease
Status
Completed
Phase
Not Applicable
Locations
Taiwan
Study Type
Interventional
Intervention
Weight-shifting training
Sponsored by
About this trial
This is an interventional treatment trial for Postural and Suprapostural Performance During Dual Tasking in Patients With Parkinson's Disease focused on measuring Parkinson, dual-task training, attention, electroencephalogram (EEG)
Eligibility Criteria
Inclusion Criteria:
- 1. modified H-Y stage II-III Parkinson's disease 2. No other diseases 3. Non-demented PD 4. Non-tremor PD
Exclusion Criteria:
- None
Sites / Locations
- National Taiwan University
Arms of the Study
Arm 1
Arm 2
Arm Type
Experimental
Experimental
Arm Label
Postural
Suprapostural
Arm Description
During training, participants in this group are instructed to focus on their posture during weight-shifting.
During training, participants in this group are instructed to focus on their suprapostural task during weight-shifting.
Outcomes
Primary Outcome Measures
EEG relative power in the delta band
postural and suprapostural performance of a dual task
EEG relative power in the theta band
postural and suprapostural performance of a dual task
EEG relative power in the alpha band
postural and suprapostural performance of a dual task
EEG relative power in the beta band
postural and suprapostural performance of a dual task
EEG relative power in the gamma band
postural and suprapostural performance of a dual task
COP trajectory recorded from the force plate
performance of the postural task
Angles from inclinometer
performance of the suprapostural task
Secondary Outcome Measures
Gait velocity from GAITRite
gait performance
Cadence from GAITRite
gait performance
Mean step length from GAITRite
gait performance
Step-to-step variability from GAITRite
gait performance
Full Information
NCT ID
NCT04288024
First Posted
February 24, 2020
Last Updated
March 16, 2021
Sponsor
National Taiwan University Hospital
1. Study Identification
Unique Protocol Identification Number
NCT04288024
Brief Title
The Learning Effects of Task-priority Strategy on Dual-task Weight Shifting and Brain Plasticity in Patients With Parkinson's Disease
Official Title
The Learning Effects of Task-priority Strategy on Dual-task Weight Shifting and Brain Plasticity in Patients With Parkinson's Disease
Study Type
Interventional
2. Study Status
Record Verification Date
February 2020
Overall Recruitment Status
Completed
Study Start Date
February 25, 2020 (Actual)
Primary Completion Date
June 22, 2020 (Actual)
Study Completion Date
June 22, 2020 (Actual)
3. Sponsor/Collaborators
Responsible Party, by Official Title
Sponsor
Name of the Sponsor
National Taiwan University Hospital
4. Oversight
Studies a U.S. FDA-regulated Drug Product
No
Studies a U.S. FDA-regulated Device Product
No
Data Monitoring Committee
No
5. Study Description
Brief Summary
(1) postural and suprapostural performance of a dual task would be differently affected by the strategy of task prioritization and (2) the cortical activation is different according to attentional focus strategies.
Detailed Description
These hypothesis would be tested by gait performance, suprapostural accuracy and relative power spectrum of EEG.
6. Conditions and Keywords
Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Postural and Suprapostural Performance During Dual Tasking in Patients With Parkinson's Disease
Keywords
Parkinson, dual-task training, attention, electroencephalogram (EEG)
7. Study Design
Primary Purpose
Treatment
Study Phase
Not Applicable
Interventional Study Model
Parallel Assignment
Masking
Participant
Allocation
Randomized
Enrollment
28 (Actual)
8. Arms, Groups, and Interventions
Arm Title
Postural
Arm Type
Experimental
Arm Description
During training, participants in this group are instructed to focus on their posture during weight-shifting.
Arm Title
Suprapostural
Arm Type
Experimental
Arm Description
During training, participants in this group are instructed to focus on their suprapostural task during weight-shifting.
Intervention Type
Behavioral
Intervention Name(s)
Weight-shifting training
Intervention Description
Postural task: Participants are standing with their weak side on the force plate. During the task, they wight-shift from side to side ranging from 10 to 90 percent of their body weight.
Suprapostural task: Participants hold a tray with their arms beside the body, 90 degrees of elbow flexion. They rotate the tray left and right for 45 degrees respectively.
During their task, participants should weight-shift and rotate the tray at the same time.
Primary Outcome Measure Information:
Title
EEG relative power in the delta band
Description
postural and suprapostural performance of a dual task
Time Frame
60 minutes
Title
EEG relative power in the theta band
Description
postural and suprapostural performance of a dual task
Time Frame
60 minutes
Title
EEG relative power in the alpha band
Description
postural and suprapostural performance of a dual task
Time Frame
60 minutes
Title
EEG relative power in the beta band
Description
postural and suprapostural performance of a dual task
Time Frame
60 minutes
Title
EEG relative power in the gamma band
Description
postural and suprapostural performance of a dual task
Time Frame
60 minutes
Title
COP trajectory recorded from the force plate
Description
performance of the postural task
Time Frame
60 minutes
Title
Angles from inclinometer
Description
performance of the suprapostural task
Time Frame
60 minutes
Secondary Outcome Measure Information:
Title
Gait velocity from GAITRite
Description
gait performance
Time Frame
5 minutes
Title
Cadence from GAITRite
Description
gait performance
Time Frame
5 minutes
Title
Mean step length from GAITRite
Description
gait performance
Time Frame
5 minutes
Title
Step-to-step variability from GAITRite
Description
gait performance
Time Frame
5 minutes
10. Eligibility
Sex
All
Minimum Age & Unit of Time
50 Years
Maximum Age & Unit of Time
85 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria:
1. modified H-Y stage II-III Parkinson's disease 2. No other diseases 3. Non-demented PD 4. Non-tremor PD
Exclusion Criteria:
None
Facility Information:
Facility Name
National Taiwan University
City
Taipei
Country
Taiwan
12. IPD Sharing Statement
Plan to Share IPD
No
Learn more about this trial
The Learning Effects of Task-priority Strategy on Dual-task Weight Shifting and Brain Plasticity in Patients With Parkinson's Disease
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