The Optimal Treatment for Treatment-resistant Schizophrenia
Schizophrenia
About this trial
This is an interventional treatment trial for Schizophrenia focused on measuring Schizophrenia
Eligibility Criteria
Inclusion Criteria:
- The diagnosis of schizophrenia according to DSM-V
- 18~60 years old
- 2 prior failed treatment trials with 2 different antipsychotics at doses of at least 600 mg/day chlorpromazine equivalents, each of at least 6 weeks duration;
- Signed an informed consent
Exclusion Criteria:
- patients to be diagnosed according to DSM-V for substance abused, development delayed
- suffering from serious physical disease and can not accept the treatment
- MST contraindications: intracranial metal substance, with heart pacemakers and cochlear implants, intracranial pressure
- allergic to risperidone ,aripiprazole, or sodium valproate
- Participated in any clinical subject within 30 days
- Pregnancy or lactation
Sites / Locations
- DTliuRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Arm 5
Arm 6
Active Comparator
Active Comparator
Active Comparator
Active Comparator
Active Comparator
Active Comparator
risperidone with clozapine
aripiprazole with clozapine
sodium valproate with clozapine
clozapine
Modified electroconvulsive therapy with clozapine
Magnetic seizure therapy with clozapine
risperidone, dosage form: 1 mg, dosage and frequency:3.0~6.0 mg/d; clozapine, dosage and frequency:300~600 mg/d; duration: 8 weeks
aripiprazole, dosage form: 5 mg, dosage and frequency:15~30 mg/day; clozapine, dosage and frequency:300~600 mg/d; duration: 8 weeks
sodium valproate, dosage form: 250 mg, dosage and frequency:600~1200 mg/day; clozapine, dosage and frequency:300~600 mg/d; duration: 3 months.
only clozapine, dosage and frequency:300~600 mg/d;
10 times MECT for 4 weeks, if the PANSS reductive ratio is less 20% in the end of 8th week by the using of risperidone with clozapine, aripiprazole with clozapine, sodium valproate with clozapine, or clozapine.
10 times MST for 4 weeks, if the PANSS reductive ratio is less 20% in the end of 8th week by the using of risperidone with clozapine, aripiprazole with clozapine, sodium valproate with clozapine, or clozapine.