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the Pharmacy Intervention Team Hospital-based (PITH) for People Study: Effect on Clinical and Economic Outcomes (PITH)

Primary Purpose

Adverse Drug Reaction, Medication Administered in Error

Status
Unknown status
Phase
Not Applicable
Locations
Netherlands
Study Type
Interventional
Intervention
integrated medicines management
Sponsored by
Clementine CM Stuijt PharmD, MSc
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional prevention trial for Adverse Drug Reaction focused on measuring Adverse Drug Events, Drug related problems, Medication Reconciliation, Medication review, discharge counseling, Hospital Pharmacy based, integrated medicines management, patient safety

Eligibility Criteria

18 Years - undefined (Adult, Older Adult)All SexesDoes not accept healthy volunteers

Inclusion Criteria:

  • > three prescribed systemic drugs intended for chronic use at admission and discharge
  • an expected length of stay of 48 hours or longer
  • insured with the Dutch insurance company Agis/Achmea
  • patients or their carers are able to express themselves in Dutch or English

Exclusion Criteria:

  • scheduled chemotherapy
  • radiation therapy
  • transplantation
  • transfer from another hospital
  • transfer from another non-eligible ward within the same hospital
  • no informed consent has been signed
  • a live expectancy less than 6 months
  • deceased during admission
  • inability to be counselled (e.g. cognitive dysfunction, language constraints)
  • discharge to a nursing home (presuming dependence on medication administration).

Patients will only be included once.

Sites / Locations

  • FlevoziekenhuisRecruiting
  • Sint Lucas Andreas Ziekenhuis
  • Medisch Centrum Leeuwarden
  • University Medical CentreRecruiting

Arms of the Study

Arm 1

Arm 2

Arm Type

Placebo Comparator

Active Comparator

Arm Label

usual care

integrated medicines management

Arm Description

During admission patients receive standard, non - ward based, pharmaceutical care from a pharmacy team in taking responsibility for the appropriate, safe and cost-effective use of medication from a central hospital pharmacy. The pharmaceutical care consist of daily screening of generated alerts by the Computerized physician order entry (CPOE) system and consultation by phone. Dependent on the local situation the current medication reconciliation process is being performed by nursing and/or medical staff either protocolised or not.

integrated medicines management consists of patient centred medication reconciliation intermediate medication review discharge counseling transfer of information to primary care

Outcomes

Primary Outcome Measures

number of rehospitalizations
this objective will be measured in three different ways: by National data extraction from hospitals (including ED visits and re-hospitalizations) as well as supporting insurance company, and by patient diaries.
number of rehospitalizations
this objective will be measured in three different ways: by National data extraction from hospitals (including ED visits and re-hospitalizations) as well as supporting insurance company, and by patient diaries.
number of rehospitalizations
this objective will be measured in three different ways: by National data extraction from hospitals (including ED visits and re-hospitalizations) as well as supporting insurance company, and by patient diaries.

Secondary Outcome Measures

numbers of ADEs
PAtients are contacted by phone. Possible ADEs are scored using a trigger list, developed by Schnipper et al, containing possible red flags on symptoms that might include alarming adverse drug reactions or deterioration of the clinical situation. In order to assess the presence of a preventable ADE, an independent team of an experienced pharmacist and a physician assesses ADEs.
numbers of DRPs
For each patient potential DRPs will be explored with a list of combined triggers based on explicit criteria extracted from literature e.g. Morimoto et al., Start and STOPP criteria and Acove in combination with a protocol based on the Harm- Wrestling report developed by the Royal Dutch Pharmaceutical Society (KNMP) in conjunction with the Healthcare Department, is used.
cost per prevented re-hospitalization
general health care use
cost like general practitioner visits, emergency department visits are extracted from insurance company data.

Full Information

First Posted
July 17, 2013
Last Updated
July 21, 2013
Sponsor
Clementine CM Stuijt PharmD, MSc
Collaborators
Insurance company Achmea Zorg
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1. Study Identification

Unique Protocol Identification Number
NCT01906710
Brief Title
the Pharmacy Intervention Team Hospital-based (PITH) for People Study: Effect on Clinical and Economic Outcomes
Acronym
PITH
Official Title
The Effect of Patient Centered Medication Reconciliation, Medication Review and Discharge Counseling With Information Transfer in Hospitalized Patients on Clinical and Economic Parameters: a Multicentre, Before-after Study.
Study Type
Interventional

2. Study Status

Record Verification Date
July 2013
Overall Recruitment Status
Unknown status
Study Start Date
January 2013 (undefined)
Primary Completion Date
December 2013 (Anticipated)
Study Completion Date
December 2014 (Anticipated)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Sponsor-Investigator
Name of the Sponsor
Clementine CM Stuijt PharmD, MSc
Collaborators
Insurance company Achmea Zorg

4. Oversight

Data Monitoring Committee
No

5. Study Description

Brief Summary
The purpose of this study is to determine whether a hospital pharmacy team (pharmacy technicians and pharmacists) together with (recently admitted) patients are able to diminish the number of drug related problems including adverse drug events, made before, during and after admissions resulting in reductions of re-hospitalizations and costs.
Detailed Description
In its 2006 report "Preventing Medication Errors," the Institute of Medicine (IOM) estimated that more than 1.5 million adverse drug events (ADEs) occur annually in the United States. On average, every hospital patient is subjected to at least one medication error every day. Medication errors are a frequent cause of ADEs. ADEs are usually defined as 'any injury due to medication use, including omission'. This may occur as an unavoidable result of the pharmacological action (better known as side effect or adverse drug reaction (ADR)) or by the manner the drug is applied (medication error or preventable ADE). ADEs can be regarded as the top of the iceberg containing all problems associated with drug therapy also known as Drug-Related Problems (DRPs). This means that besides ADEs, DRPs include other medication related problems like ADRs, medication errors, non-adherence and inadequate use of the medication by the patient. All these events can result in harm for the patient. The wide variation of prevalence of ADEs found in the literature can be explained by differences in study setting, study population, outcome (ADRs, ADEs or both) and data collection method. Anticipating who will suffer an ADE, when, and from what medication is difficult. Research has not yet identified any valid predictors of the event. Patient characteristics currently are no useful predictors of an ADE because patients who have suffered ADEs are a non homogeneous group. Although older age, severity of illness, intensity of treatment, and poly-pharmacy have been associated with ADEs, no cause and effect relationship is known to exist between patients who suffer ADEs and age, comorbidity, or number of drugs received. Around the time of hospitalization 15 to 72% of harmful events is attributed to ADEs and medication errors. ADEs are associated with substantial morbidity, increased mortality and longer length of stay in hospital and other direct costs. Nearly 1% (0,946) of patients who died during admission on an internal medicine department, were associated with the use of one or more drugs during this admission. Furthermore, a recent investigation among 21 Dutch hospitals by Hoonhout et al. revealed an excess length of stay of 6,2 days (95% CI 3.6,8.8) as a result of medication related adverse events. This figure is comparable to that of the American situation. Patients suffering from less severe ADEs (those that required a change in therapy or a longer hospital stay) had an average stay of 13 days, and patients who did not suffer an ADE had an average stay of 5 days. As a result, common reasons for admission include avoidable ADEs. Gillespie et al. investigated the effect of a ward based pharmacist on hospital admissions amongst 80 year old patients and over. After 12 months the risk on medication related readmissions had been reduced in the intervention group with 80% OR 0.20 (95% CI 0.10, 0.41). However, the total number of readmission (including medication related) showed a very balanced outcome in both intervention and control group. Generally spoken, very few studies have shown a statistical significant impact of pharmacist intervention(s) on hospital readmission. Factors influencing (re) hospitalization are complex and comprise at least medical conditions and age. The pharmacist has shown to be very effective in reducing the number of DRPs and ADEs but only few studies have established an effect on healthcare utilization so far. A recent Cochrane review on discharge planning revealed that a structured discharge plan tailored to the individual patient probably brings about small reductions in hospital length of stay and readmission rates for older people admitted to hospital. This is in line with the results of the Institute for Healthcare Improvement survey: a multi faceted program comprising close coordination of care in the post-acute period, early post-discharge follow-up, enhanced patient education and self-management training, reduced the number of rehospitalizations. For that reason we designed a multifaceted program comprising a series of interventions: on admission, during hospital stay and at discharge counseling and information transfer for other healthcare professionals. Key in this intervention process is medication reconciliation. Medication reconciliation is described as the "process of obtaining a complete and accurate list of each patient's current home medications-including name, dosage, frequency, and route of administration-and comparing the physician's admission, transfer, and/or discharge orders to that list", with the goal to provide the patients correct medications. The Joint Commission International (JCI), accrediting authority of World Health Organization (WHO) has mandated medication reconciliation as a key towards reduction of medications errors related to transition in healthcare settings. In line with overseas regulations, Dutch authorities have commanded a comparable protocol since January 2011. Pharmacy driven medication reconciliation interventions are often practised by (clinical) pharmacists and trained technicians. The efficacy of these interventions is assessed in various constitutions of teams: only technicians or only pharmacists and in-between these forms as well as in ambulatory and hospital setting. Many of these studies were found to be successful regarding significant reduction in medication errors and impact on clinical outcome. Other settings, with small samples and interventions particular without transition of information, appeared to be less flourishing specifically regarding economic outcomes. Interestingly, although the Dutch authorities have mandated medication reconciliation as an obligatory part of healthcare, few studies have been performed to measure the effect of this intervention. Therefore, effects of interventions of a hospital based pharmacy team on number of unplanned re-hospitalizations and ADEs or frequency of medication related harms as a result of ADEs, are mixed or unknown. Furthermore, no studies have addressed the extent to which ADRs and ADEs amongst both acutely and electively admitted patients can be detected and diminished by pharmacists. Also, very limited data exist regarding differences in prevalence of ADRs and ADEs between study wards. It thus appears that these subjects still have to be addressed. Therefore, a study is performed to establish the impact of a hospital pharmacy team on number and economic impact of unplanned re-hospitalizations. To determine independent contributions of various factors to the primary endpoint, age, sex, Charlson Co-morbidity index,renal function, hospital site, ward type, being admitted 6 months before index admission, quality of live (EuroQoL D5), culture on the ward, patient and healthcare professionals satisfaction and use of high risk drugs will be included in the logistic regression analysis. Also, occurence of DRPs and ADEs, with a focus on reduction of the frequency of ADEs and time spend by the pharmacy team with subsequent costs per prevented ADE and DRP as compared to usual pharmaceutical care will be calculated. Other healthcare uses like emergency department visits, length of stay, general practitioner consultations and drug consumption during post discharge period will be studied. The research questions are: Does the introduction of protocolised medication reconciliation and discharge service by a hospital pharmacy team influence the number of unplanned re-hospitalizations and ADEs? What DRPs occur and how often do DRPs occur? Which DRPs are highly correlated with unplanned readmissions and ADEs? Does the introduction of protocolised medication reconciliation by a hospital pharmacy team influence insurance costs caused by reduction of length of hospital stay, number of unplanned re-hospitalizations or readmissions, emergency visits, general practitioner visits, direct medicine cost within 14 days, 3 and 6 months after index admission? Can we extract from this information what the costs are per prevented ADE? Is the satisfaction with information about medicines of included patients changed compared to control? Is the satisfaction with the introduction of a pharmaceutical team for medication reconciliation of healthcare professionals changed compared to control? Which patients or circumstances are at high risk for DRP or ADEs? What is the time spend on patient centred medication reconciliation, discharge counselling, intermediate medication review? Design A multi - centre prospective, before-after study will be performed. Each of the 4-6 participating centers have selected a predefined ward, namely emergency department, internal medicine, neurology, surgery, or cardiology. Per ward type 300 patients are planned to be included, comprising both before- and after period. Thus, 150 patients per arm per ward are included. First, over a 3 to 4 month period baseline assessments in each hospital in the participating wards will be performed (control or usual care group). Secondly, the intervention is implemented on all included study wards, after a brief education of hospital pharmacy teams. Finally, during the 3 to 4 months intervention phase, patients are included. Both groups have a follow-up period of 6 months.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Adverse Drug Reaction, Medication Administered in Error
Keywords
Adverse Drug Events, Drug related problems, Medication Reconciliation, Medication review, discharge counseling, Hospital Pharmacy based, integrated medicines management, patient safety

7. Study Design

Primary Purpose
Prevention
Study Phase
Not Applicable
Interventional Study Model
Single Group Assignment
Masking
None (Open Label)
Allocation
Non-Randomized
Enrollment
1200 (Anticipated)

8. Arms, Groups, and Interventions

Arm Title
usual care
Arm Type
Placebo Comparator
Arm Description
During admission patients receive standard, non - ward based, pharmaceutical care from a pharmacy team in taking responsibility for the appropriate, safe and cost-effective use of medication from a central hospital pharmacy. The pharmaceutical care consist of daily screening of generated alerts by the Computerized physician order entry (CPOE) system and consultation by phone. Dependent on the local situation the current medication reconciliation process is being performed by nursing and/or medical staff either protocolised or not.
Arm Title
integrated medicines management
Arm Type
Active Comparator
Arm Description
integrated medicines management consists of patient centred medication reconciliation intermediate medication review discharge counseling transfer of information to primary care
Intervention Type
Other
Intervention Name(s)
integrated medicines management
Intervention Description
PITH includes the following interventions: A) MR on admission to obtain an up-to-date medication list, B) Intermediate medication review during hospitalization C) MR at discharge to maintain an up-to-date medication overview, counseling of the patient at hospital discharge and preparation of the patient to manage their medication at home., Written material is provided for oral support, which includes an overview of the current medication, a summary of potentially important side effects, advices on medication use and hospital pharmacy contact information in order to answer any possible questions, D) Information transfer to GP/community pharmacist at discharge
Primary Outcome Measure Information:
Title
number of rehospitalizations
Description
this objective will be measured in three different ways: by National data extraction from hospitals (including ED visits and re-hospitalizations) as well as supporting insurance company, and by patient diaries.
Time Frame
6 months
Title
number of rehospitalizations
Description
this objective will be measured in three different ways: by National data extraction from hospitals (including ED visits and re-hospitalizations) as well as supporting insurance company, and by patient diaries.
Time Frame
14 days
Title
number of rehospitalizations
Description
this objective will be measured in three different ways: by National data extraction from hospitals (including ED visits and re-hospitalizations) as well as supporting insurance company, and by patient diaries.
Time Frame
42 days
Secondary Outcome Measure Information:
Title
numbers of ADEs
Description
PAtients are contacted by phone. Possible ADEs are scored using a trigger list, developed by Schnipper et al, containing possible red flags on symptoms that might include alarming adverse drug reactions or deterioration of the clinical situation. In order to assess the presence of a preventable ADE, an independent team of an experienced pharmacist and a physician assesses ADEs.
Time Frame
14 days after discharge
Title
numbers of DRPs
Description
For each patient potential DRPs will be explored with a list of combined triggers based on explicit criteria extracted from literature e.g. Morimoto et al., Start and STOPP criteria and Acove in combination with a protocol based on the Harm- Wrestling report developed by the Royal Dutch Pharmaceutical Society (KNMP) in conjunction with the Healthcare Department, is used.
Time Frame
on admission at discharge
Title
cost per prevented re-hospitalization
Time Frame
6 months
Title
general health care use
Description
cost like general practitioner visits, emergency department visits are extracted from insurance company data.
Time Frame
6 months

10. Eligibility

Sex
All
Minimum Age & Unit of Time
18 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria: > three prescribed systemic drugs intended for chronic use at admission and discharge an expected length of stay of 48 hours or longer insured with the Dutch insurance company Agis/Achmea patients or their carers are able to express themselves in Dutch or English Exclusion Criteria: scheduled chemotherapy radiation therapy transplantation transfer from another hospital transfer from another non-eligible ward within the same hospital no informed consent has been signed a live expectancy less than 6 months deceased during admission inability to be counselled (e.g. cognitive dysfunction, language constraints) discharge to a nursing home (presuming dependence on medication administration). Patients will only be included once.
Central Contact Person:
First Name & Middle Initial & Last Name or Official Title & Degree
CCM stuijt, PharmD
Phone
31633568067
Email
stuijt@apomed.nl
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Bart van den Bemt, PharmD, PhD
Organizational Affiliation
Maartenskliniek
Official's Role
Study Director
First Name & Middle Initial & Last Name & Degree
Fatma Karapinar, PharmD
Organizational Affiliation
LucasAndreas hospital
Official's Role
Principal Investigator
Facility Information:
Facility Name
Flevoziekenhuis
City
Almere
ZIP/Postal Code
1315 RA
Country
Netherlands
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
HT Ensing, PharmD
Phone
31365454378
Email
rensing@zorggroep-almere.nl
First Name & Middle Initial & Last Name & Degree
M Zegstroo, pharm techn.
Phone
31368688537
Email
mzegstroo@flevoziekenhuis.nl
First Name & Middle Initial & Last Name & Degree
Rik Ensing, PharmD
Facility Name
Sint Lucas Andreas Ziekenhuis
City
Amsterdam
Country
Netherlands
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
MJA Janssen, PharmD, PhD
Phone
0031205108911
Ext
319
Email
m.j.a.janssen@slaz.nl
First Name & Middle Initial & Last Name & Degree
MJA Janssen, PharmD, PhD
Facility Name
Medisch Centrum Leeuwarden
City
Leeuwarden
ZIP/Postal Code
8901BR
Country
Netherlands
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
A Jansen, PharmD
Phone
31582861295
Email
anita.jansen@znb.nl
First Name & Middle Initial & Last Name & Degree
Anita Jansen, PharmD
Facility Name
University Medical Centre
City
Utrecht
Country
Netherlands
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
A de Roos
Email
A.M.deRoos-2@umcutrecht.nl
First Name & Middle Initial & Last Name & Degree
S v Lieshout-Bocxe, PharmD

12. IPD Sharing Statement

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the Pharmacy Intervention Team Hospital-based (PITH) for People Study: Effect on Clinical and Economic Outcomes

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