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The Relationship Between Autobiographical Memory and Motivation

Primary Purpose

Psychosis

Status
Unknown status
Phase
Not Applicable
Locations
United Kingdom
Study Type
Interventional
Intervention
Guided Autobiographical Memory Recall
Sponsored by
King's College London
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional basic science trial for Psychosis focused on measuring Negative Symptoms, Autobiographical Memory

Eligibility Criteria

18 Years - 65 Years (Adult, Older Adult)All SexesDoes not accept healthy volunteers

Inclusion Criteria:

  • A diagnosis of non-affective psychosis (as determined by medical records).
  • Above 18yrs old.
  • A score of at least 18 on the Clinical Assessment Interview for Negative Symptoms.
  • A sufficient command of the English language to engage with the research materials

Exclusion Criteria:

  • Lack of capacity to provide informed consent.
  • Primary diagnosis of intellectual disability, head injury, substance misuse or known organic cause of psychosis

Sites / Locations

  • South London and Maudsley NHS Trust
  • Institute of Psychiatry, Psychology & Neuroscience, KCL

Arms of the Study

Arm 1

Arm 2

Arm Type

Experimental

No Intervention

Arm Label

Intervention

Control

Arm Description

Guided autobiographical memory recall to enhance specificity and links to the future.

Recall without prompts or psychoeducation video.

Outcomes

Primary Outcome Measures

Change in Motivation
A change in ratings on a visual analogue scale assessing motivation to repeat the same activity recalled in the future.The scale is rated from 0-100 and a higher score indicated better outcome. This scale will be reported separately and not combined with others.

Secondary Outcome Measures

Change in Anticipatory Pleasure
A change in ratings on a visual analogue scale assessing how pleasant that activity is anticipated to be if repeated.The scale is rated from 0-100 and a higher score indicated better outcome. This scale will be reported separately and not combined with others.
Change in Self-efficacy
A change in ratings on a visual analogue scale assessing how able the participant feels to engage in that activity if repeated.The scale is rated from 0-100 and a higher score indicated better outcome. This scale will be reported separately and not combined with others.

Full Information

First Posted
February 10, 2017
Last Updated
September 17, 2018
Sponsor
King's College London
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1. Study Identification

Unique Protocol Identification Number
NCT03677635
Brief Title
The Relationship Between Autobiographical Memory and Motivation
Official Title
Is There a Relationship Between Memory for Past Events and Motivation for Future Activities?
Study Type
Interventional

2. Study Status

Record Verification Date
September 2018
Overall Recruitment Status
Unknown status
Study Start Date
May 18, 2017 (Actual)
Primary Completion Date
March 31, 2018 (Actual)
Study Completion Date
January 31, 2019 (Anticipated)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Sponsor
Name of the Sponsor
King's College London

4. Oversight

Studies a U.S. FDA-regulated Drug Product
No
Studies a U.S. FDA-regulated Device Product
No
Data Monitoring Committee
No

5. Study Description

Brief Summary
People with a diagnosis of psychosis often experience low motivation and pleasure when thinking about doing future activities. This leads, quite understandably, to doing fewer activities they used to enjoy and not taking up opportunities to do new activities. One model suggests that this may be partly due to difficulties using memories of previous events to help boost motivation and anticipation before a future activity. Research shows that people with psychosis may recall previous events in less detail. These memories therefore may not be as helpful as they could be for motivation. This study will investigate this by asking people with experience of psychosis and low motivation who are seen by a care team in South London and Maudsley NHS Trust to attend two research sessions. In the first session they will be asked to recall memories of events from their lives and the researcher will assess how detailed they are and how much they refer to the past and future. Alongside this task people will also be asked to complete measures of symptoms such as low pleasure and motivation as well as a measure of depression. These will be used to find out if the detail and specificity of the memories are related to these symptoms in people with psychosis. The second half of the study will then investigate whether additional prompts to support positive memory retrieval can increase the specificity of this and subsequently improve mood, motivation and self-belief. Participants will be randomised to one of two groups. The clinical group will be guided through their memory recall using prompts and a control group will be asked to recall positive memories without prompts. If we show that supporting memory recall is beneficial then memories for past events may be an important target for future therapies.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Psychosis
Keywords
Negative Symptoms, Autobiographical Memory

7. Study Design

Primary Purpose
Basic Science
Study Phase
Not Applicable
Interventional Study Model
Parallel Assignment
Masking
Participant
Allocation
Randomized
Enrollment
40 (Anticipated)

8. Arms, Groups, and Interventions

Arm Title
Intervention
Arm Type
Experimental
Arm Description
Guided autobiographical memory recall to enhance specificity and links to the future.
Arm Title
Control
Arm Type
No Intervention
Arm Description
Recall without prompts or psychoeducation video.
Intervention Type
Behavioral
Intervention Name(s)
Guided Autobiographical Memory Recall
Intervention Description
Participants are asked to recall positive autobiographical memories with the assistance of prompts to promote specificity, generalisability and links to the future. The participants will also view a 5min psychoeducation video on the subject of memory specificity and motivation.
Primary Outcome Measure Information:
Title
Change in Motivation
Description
A change in ratings on a visual analogue scale assessing motivation to repeat the same activity recalled in the future.The scale is rated from 0-100 and a higher score indicated better outcome. This scale will be reported separately and not combined with others.
Time Frame
Immediately before and after completing the intervention (20mins apart)
Secondary Outcome Measure Information:
Title
Change in Anticipatory Pleasure
Description
A change in ratings on a visual analogue scale assessing how pleasant that activity is anticipated to be if repeated.The scale is rated from 0-100 and a higher score indicated better outcome. This scale will be reported separately and not combined with others.
Time Frame
Immediately before and after completing the intervention (20mins apart)
Title
Change in Self-efficacy
Description
A change in ratings on a visual analogue scale assessing how able the participant feels to engage in that activity if repeated.The scale is rated from 0-100 and a higher score indicated better outcome. This scale will be reported separately and not combined with others.
Time Frame
Immediately before and after completing the intervention (20mins apart)

10. Eligibility

Sex
All
Minimum Age & Unit of Time
18 Years
Maximum Age & Unit of Time
65 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria: A diagnosis of non-affective psychosis (as determined by medical records). Above 18yrs old. A score of at least 18 on the Clinical Assessment Interview for Negative Symptoms. A sufficient command of the English language to engage with the research materials Exclusion Criteria: Lack of capacity to provide informed consent. Primary diagnosis of intellectual disability, head injury, substance misuse or known organic cause of psychosis
Facility Information:
Facility Name
South London and Maudsley NHS Trust
City
London
ZIP/Postal Code
BR3 3BX
Country
United Kingdom
Facility Name
Institute of Psychiatry, Psychology & Neuroscience, KCL
City
London
ZIP/Postal Code
SE5 8AF
Country
United Kingdom

12. IPD Sharing Statement

Plan to Share IPD
Undecided

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The Relationship Between Autobiographical Memory and Motivation

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