The Role of Amylin and Glucagon in T1DM
Type 1 Diabetes
About this trial
This is an interventional treatment trial for Type 1 Diabetes focused on measuring type 1 diabetes, hypoglycemia, hyperglycemia
Eligibility Criteria
Inclusion Criteria: Age >12 years < 19 years Have diabetes for at least 2 years and in good control (HbA1C < 8%). Be on continuous subcutaneous insulin infusion using an insulin pump. Subjects must be otherwise healthy except for their T1DM and treated for hypothyroidism. Menstruating women must have negative pregnancy test. Hemoglobin equal to or > than 12 g/dL before each study. Weight more than 44 kg. Exclusion Criteria: Age >18 or < 12 y at the time of study Any chronic disease (leukemia, asthma, inflammatory bowel disease, cystic fibrosis, juvenile rheumatoid arthritis, etc that directly, or as a result of treatment, directly or indirectly affect glucose homeostasis Hemoglobin less than 12 g/dl (If before any of the studies the hemoglobin is lower than 12 g/dl, subjects will be excluded from further studies) Lack of a supportive family environment Positive pregnancy test in menstruating young women Evidence or history of chemical abuse Hgb A1c >8.0 % in a diabetic subject BMI > 90 % tile for age or < 10 % tile for age Allergy to local anesthetics (ELAMAX Cream) Weight less than 44 kg Children of staff members
Sites / Locations
- Baylor College of Medicine