The Sahlgrenska Anti-VEGF Study (SAHLVE)
Neovascular Age-related Macular Degeneration
About this trial
This is an interventional treatment trial for Neovascular Age-related Macular Degeneration
Eligibility Criteria
Inclusion Criteria:
Signed informed consent.
≥50 years, regardless of gender.
Diagnosed with the neovascular (wet) form of age-related macular degeneration through diagnosed neovascular vascular membranes with OCT-A and, if necessary, also FA / ICG, according to clinical routine.
Distance visual acuity ≥34 (ETDRS) on the current study eye.
Exclusion Criteria:
Other eye disease in the current study eye that affects visual acuity or the possibility of examining fundus, according to the investigator's assessment.
Previously received treatment for the neovascular (wet) form of age-related macular degeneration.
Diagnosed with diabetes (all types).
Degenerative state of the macula that prevents vision improvement such as central areolar atrophy or other pronounced dry AMD or fibrosis, in the current study eye.
Other choroidal neovascularization (CNV) of the type PCV or due to grave myopia i.e. ≥ 6.0 diopters (D) or secondary to other retinal disease, in the current study eye.
Unregulated intraocular pressure (IOP) > 30 mmHg despite pharmacological treatment in the current study eye.
Have had a stroke or heart attack ≤6 months ago.
Inability to access information (e.g. due to dementia) or inability to conduct examinations (e.g. ETDRS examination), according to the investigator's assessment.
Inability to receive oral and written information in Swedish (in need of an interpreter).
Included in another intervention study.
Fertile woman i.e. a woman who has had menstruation for the past 12 months or has not undergone permanent sterilization (hysterectomy, bilateral salpingectomy or bilateral oophorectomy).
Sites / Locations
- Vastra Gotaland Region, Sahlgrenska University Hospital, Department of OphthalmologyRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
Avastin
Eylea
bevacizumab 25 mg/ml, intravitreal administration, 0.05 ml (1.25 mg)
aflibercept 40 mg/ml, intravitreal administration, 0.05 ml (2 mg)