The Saint Francis Remote Ischemic Preconditioning Trial (SaFR) (SaFR)
Coronary Artery Disease
About this trial
This is an interventional prevention trial for Coronary Artery Disease focused on measuring Coronary Atherosclerosis, Percutaneous Coronary Intervention, Coronary Stenting, Coronary Stenosis, Remote Ischemic Preconditioning
Eligibility Criteria
Inclusion Criteria:
- Patients with stable chronic coronary artery disease scheduled for elective percutaneous intervention.
Exclusion Criteria:
- Recent (1 month) myocardial infarction
- Acute coronary syndrome
- Chest pain at res
- Estimated glomerular filtration rate(GFR)<45 mL/min/1.73 m2
- Frequent premature atrial or ventricular contractions or atrial fibrillation
- Any contraindication to MRI including implanted non MRI compatible medical devices or ferromagnetic materials such as shrapnel
- Inability to breath-hold
- Severe claustrophobia
- Deafness
- Persistent tremor
- Inability to follow instructions.
Sites / Locations
- St. Francis Hospital-The Heart Center
Arms of the Study
Arm 1
Arm 2
Experimental
Placebo Comparator
Remote Ischemic Preconditioning (RIPC)
Sham Remote Ischemic Preconditioning
Randomized subjects who are treated immediately prior to stenting with remote ischemic preconditioning consisting of 3 5 minute blood pressure cuff inflations to occlude the brachial artery in their nondominant arms, with intervening 5 minute rest periods.
Patients who prior to stenting have the RIPC blood pressure cuff placed but not inflated for 3 5 minute episodes with 5 minute rest periods.