The Second Multicenter Hemophilia Cohort Study
Liver Decompensation, Hepatocellular Carcinoma, Non-Hodgkin Lymphoma
About this trial
This is an observational trial for Liver Decompensation focused on measuring AIDS, Cancer, Hepatitis C Virus, HIV, Natural History, Hemophilia, Hepatitis C
Eligibility Criteria
INCLUSION CRITERIA: Must be registered patient with an inherited coagulation disorder at a participating MHCS-II center. Disorders include hemophilia A or B (congenital factor VIII or IX deficiency), deficiencies in other factors such as V or XI, and vonWillebrand's disease. (Unless noted otherwise, all of the disorders will collectively be referred to as hemophilia .) All such hemophilia and vonWillebrand s disease patients are to be recruited as study participants. Since January 1, 1993, must have had at least one positive result on a licensed assay for HCV antibodies, HIV antibodies, or HIV RNA. Must be at least 13 years of age at enrollment. Must provide signed informed consent or, for minors, signed assent plus signed informed consent from the parent or guardian. EXCLUSION CRITERIA: Is not a patient with an inherited coagulation disorder. Does not have a positive test for HCV antibodies, HIV antibodies, or HIV RNA on a licensed assay performed since January 1, 1993. Is less than 13 years of age. Lacks informed consent/assent.
Sites / Locations
- University of Arizona
- University of California, Davis
- Children's Hospital of Orange County
- University of California, San Francisco
- University of Colorado
- Christiana Hospital
- Georgetown University
- Childrens National Medical Center
- Emory University
- University of Illinois
- Childrens Memorial Hospital, Chicago
- St. Vincent's Hospital
- Tulane University
- Wayne State University Hutzel Hospital
- University of Minnesota
- University of Mississippi
- St. Louis University
- University of New Mexico
- University of Buffalo
- North Shore Long Island Jewish Health System
- Cornell University
- Mt. Sinai Medical Center
- University of North Carolina
- Wake Forest University
- Childrens Hospital, Cinncinati
- University of Cincinnati
- Ohio State University
- Wright State University
- University of Oklahoma
- Milton Hershey Medical Center
- University of Pennsylvania
- Thomas Jefferson University
- Palmentto Health Alliance
- University of Tennessee
- Vanderbilt University
- University of Texas, Houston
- University of Texas, San Antonio
- University of Utah
- Childrens Hospital of Wisconsin
- Hospital Brigadeiro
- University of Sao Paulo
- South East Health Care Corporation
- Hospices Civils de Lyon
- University of Bonn
- Laikon General Hospital of Athens
- University of Florence
- University de Milano
- Karolinska Institute St. Gorans Hospital