The Study to Assess AMI Treated With Balloon Angioplasty. (TYPHOON)
Coronary Artery Disease
About this trial
This is an interventional treatment trial for Coronary Artery Disease
Eligibility Criteria
Inclusion Criteria: Have prolonged, continuous (lasting at least 20 minutes) chest pain despite administration of nitrates and onset within 12 hours of randomization, and one of the following: ST segment elevation >=1mm in standard leads and >=2mm in 2 or more contiguous precordial leads with reciprocal ST depression New or presumably new left bundle branch block (LBBB) The culprit lesion must be identified on a de novo native coronary artery and an emergency angioplasty must be possible. The culprit site must be visualized before the stent implantation; Exclusion Criteria: Killip class > 2 upon arrival to the cath-lab; Significant (>50%) stenosis proximal or distal to the target lesion that might require revascularization or impede inflow or runoff; Evidence of massive thrombus in the infarct related artery distally to the culprit lesion; Documented left ventricular ejection fraction <=30%; Target lesion is located in an arterial or venous by-pass graft; ECG documented evidence of prior myocardial infarction; Patient who received thrombolytic therapy for the current AMI before enrollment in this study.
Sites / Locations
- HOPITAL COCHIN, René Descartes University
- University of Freiburg, Albert-Ludwigs-Universitätskliniken
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
1
2
Cypher Sirolimus-eluting Coronary Stent
Bare-metal stent