Therapeutic Trial Comparing Triple Therapy Guided by the PCR Detection of Clarithromycin Resistance vs Empiric Concomitant Quadruple Therapy for Helicobacter Pylori Infection (Hepysé)
H Pylori Infection Eradication, Antibiotics Therapeutic Strategies, H Pylori Eradication
About this trial
This is an interventional treatment trial for H Pylori Infection Eradication focused on measuring Naïve patient, Suspicion of H pylori infection, Endoscopy, Antibiotics therapeutic strategies, Urea breath test
Eligibility Criteria
Inclusion Criteria:
- Adult patients ≥ 18 years
- Hospitalized or out-patients referred to one of the participating centers for upper gastrointestinal endoscopy
- Who did not received a previous eradication treatment
- Willing to participate and signed inform consent. Finally only patients with bacteriologically documented H. pylori infection (PCR) will be included.
Exclusion Criteria:
- Patient having already been treated to eradicate H pylori
- No affiliation to social insurance
- Person under legal protection
- Refusal for signing informed consent
- Patient included in another trial with medication
- Patient unable to take oral medication ongoing
- Patient with severe life-threatening disease in the short term
- Contraindication to the PPIs, amoxicillin, metronidazole, clarithromycin, levofloxacin, tetracyclin or bismuth
- Patient under treatment with antibiotics or PPI without possibility of interruption for 4 weeks
- Pregnant or breast-feeding woman
Sites / Locations
- Henri Mondor HospitalRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
Triple therapy guided by result of the molecular resistance
Quadruple concomitant therapy
If clarithromycin S : high dose PPI (Esoméprazole 40mg X 2/ d) - amoxicillin 1gX2 / d - clarithromycin 500mgX2 / d The total duration of treatment is 14 days. If clarithromycin R: high dose PPI (Esoméprazole 40mg X 2/ d) - amoxicillin 1gX2 / d- levofloxacin 500mg X2 / d The total duration of treatment is 14 days.
high dose PPI (Esoméprazole 40 mg X 2 / d- amoxicillin 1gX2 / d - - clarithromycin 500mgX2 / d - metronidazole 500mgX2 / d for 14 days