Thyroid and Adrenocortical Hormone Replacement in Organ Donors
Brain Death
About this trial
This is an interventional treatment trial for Brain Death
Eligibility Criteria
Inclusion Criteria:
Cadaveric organ donors ≥ age 18 having valid consent (by advance directive or by familial consent) to donate organs.
Recipients of these cadaveric organs
Exclusion Criteria:
Cadavers failing to meet inclusion criteria
Sites / Locations
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Experimental
Experimental
Experimental
No Intervention
Levothyroxine
Methylprednisolone
Combination
Control
Levothyroxine 20 mcg IV bolus initiated at the beginning of active donor management followed by continuous infusion of 50 to 200 mcg/hr titrated to minimize vasopressor requirements until organ procurement.
Methylprednsiolone 30 mg/kg (up to 2 g) IV initiated at the beginning of active donor management followed by repeat dosing of 15 mg/kg (up to 1 g) 12 hours later.
Methylprednsiolone 30 mg/kg (up to 2 g) IV initiated at the beginning of active donor management followed by repeat dosing of 15 mg/kg (up to 1 g) 12 hours later plus levothyroxine 20 mcg IV bolus initiated at the beginning of active donor management followed by continuous infusion of 50 to 200 mcg/hr titrated to minimize vasopressor requirements until organ procurement.
No levothyroxine or methylprednisolone administered.