Timing of Voluntary Movement in Patients With Schizophrenia
Schizophrenia
About this trial
This is an observational trial for Schizophrenia focused on measuring Bereitschafts Potential, Timing of Volition, Somatic Passivity Phenomenon, Conscious Will, Libet's Clock, Schizophrenia, Healthy Volunteer, HV
Eligibility Criteria
INCLUSION CRITERIA: SCHIZOPHRENIC PATIENTS: Experimental subjects will be patients with DSM-IV diagnosis of schizophrenia who have volunteered to participate in the clinical research unit of the Clinical Brain Disorders Branch, NIMH. In addition, outpatients with DSM-IV diagnosis of schizophrenia who participate in outpatient research through the CBDB will be included. All patients will have received the diagnosis of schizophrenia by means of the Structured Clinical Interview for DSM-IV (SCID) with three psychiatrists reaching a consensus diagnosis. Patients on the clinical research unit must meet rigorous criteria in order to participate in research. Exclusionary criteria include history of traumatic brain injury, known comorbid neurological disorders, including epilepsy, history of drug and alcohol abuse, etc. All patients will have undergone a comprehensive battery of neuropsychological tests, including Wide Range Achievement Test- Reading (often to be a good indicator of premorbid intelligence), a short version of Wechsler Adult Intelligence Scale (WAIS-R), Wechsler Memory Scales (WMS-R), Trails A and B, tests of attention and executive function, including the continuous performance test (CPT), Wisconsin Card Sort (WISC), the N-Back test of working memory. Patients with psychiatric diseases other than schizophrenia that are not currently active and symptomatic will be included. All patients in the study will have schizophrenia. However, at the time of testing, patients will be administered clinical rating scales (i.e., Brief Psychotic Rating Scale (BPRS), appropriate sections of the SCID and the Yale Hallucination Phenomenology Assessment (YHPA)) to determine the presence of passivity phenomena. NORMAL VOLUNTEERS: Twenty-six normal controls will be included; controls will be screened in the NINDS Movement Disorders Outpatient Clinic, and will have neurological and physical examinations. They will be asked to abstain from alcohol for 24 hours before the study. All subjects participating in the studies will have a valid Clinical Center Medical Record Number. ALL SUBJECTS: All subjects will be between the ages of 18 and 65. Subjects may be male or female. EXCLUSION CRITERIA: Patients younger than 18 years old or older than 65 years old will be excluded from the study. A. Patients with neurological disorders will be excluded. Patients with psychiatric disorders other than schizophrenia who are experiencing an active phase of their disorder will be excluded. B. Patients with a history of significant medical disorders requiring chronic treatment with other drugs, which affect the central nervous system and cannot be stopped will be excluded. C. Patients not capable of giving an informed consent will be excluded.
Sites / Locations
- National Institutes of Health Clinical Center, 9000 Rockville Pike