Tissue Destruction and Healing in Celiac Disease
Celiac Disease
About this trial
This is an interventional diagnostic trial for Celiac Disease focused on measuring gluten-free diet, HLA-DQ2, HLA-DQ8, microbiome, metagenomics, intestinal epithelial cells
Eligibility Criteria
Inclusion Criteria: Gluten challenge group: Age 18 to 70 years old Diagnosis of Celiac disease for at least 12 months by intestinal biopsy Follow a strict gluten-free diet for at least the 12 consecutive months Gluten de-challenge group: Age 18 to 70 years old Showing typical celiac disease symptoms Not on a gluten-free diet Control group: Age 18 to 70 years old Females who are not pregnant Exclusion Criteria: Gluten challenge group: Diagnosis of any severe complication of celiac disease Diagnosis of other chronic, active GI disease Selective IgA deficiency Severe reaction to gluten exposure Any clinically significant diseases History of significant substance or alcohol abuse Pregnant or lactating Diagnosis of blood clotting disorders Gluten de-challenge group: History of chronic inflammatory gastrointestinal disease Gastrointestinal illness within the 4-week period prior to screening History of lymphoproliferative disease Uncontrolled blood clotting disorders Any clinically significant diseases History of significant substance or alcohol abuse Control group: Taking antibiotics, proton pump inhibitors, aspirin, or non-steroidal anti-inflammatory drugs Known intestinal inflammation Prior gastrointestinal surgery Taking of antiplatelet agents or anticoagulants Family history of celiac disease
Sites / Locations
- California Institute of Technology
- The University of ChicagoRecruiting
- Mayo Clinic
Arms of the Study
Arm 1
Arm 2
Arm 3
Experimental
No Intervention
No Intervention
Gluten challenge group
Gluten de-challenge group
Control group
Diagnosis of celiac disease by intestinal biopsy and serology for at least 12 months
Suspected celiac disease either showing typical symptoms or positive celiac disease serology
No history or symptoms of celiac disease