TLK286 (Telcyta) vs. Doxil/Caelyx or Hycamtin in Platinum Refractory or Resistant Ovarian Cancer
Ovarian Neoplasms
About this trial
This is an interventional treatment trial for Ovarian Neoplasms focused on measuring ovary
Eligibility Criteria
Inclusion criteria include: Considered platinum refractory or resistant according to standard criteria Progressed during or following completion of one second-line treatment with Doxil/Caelyx or Hycamtin Histologically or cytologically confirmed diagnosis of epithelial cancer of the ovary, fallopian tube, or primary peritoneal cancer Measurable disease according to RECIST criteria with documented tumor progression Exclusion criteria include: Treatment with second-line chemotherapy other than Doxil/Caelyx or Hycamtin History of whole pelvis radiation therapy within 12 months of enrollment Clinically significant cardiac disease Evidence of gross hematuria at the time of study entry Any signs of intestinal obstruction interfering with nutrition at the time of study entry Pregnant or lactating women
Sites / Locations
- Little Rock Hematology Oncology Associates
- University of Arkansas for Medical Sciences
- Southern California Permanente Medical Group
- Providence Saint Joseph Medical Center
- Marilyn Norton, M. D.
- Rosalba Rodriguez, M. D.
- Bay Area Research Cancer Group
- Southwest Cancer Care
- California Oncology of the Central Valley
- Kaiser Permanente Oncology Clinical Trials Program
- Gynecologic Oncology Associates
- Grossmont Hospital
- Sharp Rees-Stealy
- LLU Faculty Medical Offices
- LLU Faculty Meidical Offices
- Loma Linda University Medical Center
- David Geffen School of Medicine at UCLA
- Women's Cancer Center - Community Hospital Los Gatos
- Southwest Cancer Care
- Gyncologic Oncology Associates
- Kaiser Permanente Oncology Clinical Trials Program
- N. County Oncology Medical
- Southwest Cancer Care
- Kaiser Permanente Oncology Clinical Trials Program
- Kaiser Permanente Oncology Clinical Trials Program
- Kaiser Permanente Oncology Clinical Trials Program
- Southern California Permanente Medical Group
- Medical Oncology Associates-SD
- Sharp Healthcare Clinical Oncology Research
- Sharp Memorial Hospital
- Sharp Rees-Stealy
- Kaiser Permanente Oncology Clinical Trials Program
- Kaiser Permanente Oncology Clinical Trials Program
- Kaiser Permanente Oncology Clinical Trials Program
- Kaiser Permanente Oncology Clinical Trials Program
- Kaiser Permanente Oncology Clinical Trails Program
- Kaiser Permanente Oncology Clinical Trials Program
- Kaiser Permanente Oncology Clinical Trials Program
- Kaiser Permanente Oncology Clinial Trials Program
- Whittingham Cancer Center at Norwalk Hospital
- Hematology Oncology, P.C.
- The Center for Hematology-Oncology
- The Center for Hematology-Oncology
- Memorial Regional Hospital
- Sheridan Clinical Research, Inc.
- University of Florida Health Science Center/Jacksonville
- Florida Hospital
- Gynecologic Oncology
- Florida Hospital Memorial Division, Cancer Care Center
- Florida Hospital Memorial Division
- Palm Beach Cancer Institute
- Gynecologic Oncology Associates
- Hematology/Oncology Associates of Treasure Coast
- Women's Cancer Research Foundation, Inc.
- Palm Beach Cancer Institute
- Palm Beach Cancer Institute
- Suburban Hematology Oncology
- Suburban Hematology-Oncology Associates
- Memorial Health University Medical Center
- Suburban Hematology Oncology
- Kaiser Permanente - Moanalua Medical Center
- Straub Clinic and Hospital
- Univ. of Hawaii, Kapiolani Medical Center for Women and Children
- North Shore Oncology Hematology Associates
- MacNeal Cancer Center
- Swedish Covenant Cancer Center
- Hematology Oncology Associates of Illinois (HOAI)
- Cancer Care Specialists of Central IL
- Decatur Memorial Hospital
- Cancer Care Specialists of Central IL-Crossroads Cancer Care Center
- Joliet Oncology-Hematology Associates, Ltd.
- Joliet Oncology-Hematology Associates, Ltd.
- North Shore Oncology Hematology Associates - Deerpath Medical Associates
- North Shore Oncology Hematology Associates
- North Shore Oncology Hematology Associates
- Joliet Oncology-Hematology Associates, Ltd.
- Hematology Oncology Associates of Illinois (HOAI)
- Midwest Cancer Research Group, Inc.
- Elkhart General Hospital
- Michiana Hematology Oncology
- Indiana Cancer Pavilion
- Indiana University Medical Center
- St. Vincent Gynecologic Oncology
- St. Vincent Hospital and Health Care Center
- St. Vincent Hospital and Helath Care Center
- Michiana Hematology Oncology
- St. Joseph's Regional
- Saint Joseph's Regional
- University of Iowa Hospitals and Clinics
- University of Iowa
- Research Support Personnel, LLC
- Associates in Women's Health
- Oncology/Hematology Care, Inc.
- Univ. of Louisville, Div. of Gynecologic Oncology
- Hematology and Oncology Specialists, LLC
- OncRx (Pharmacy)
- Hematology and Oncology Specialists, LLC
- Ochsner Clinic Foundation
- LSU Health Sciences Center
- Sinai Cancer Institute
- Center for Cancer and Blood Disorders
- St. Elizabeth's Med. Ctr.
- St. Joseph Mercy Hospital
- Sparrow Regional Cancer Center
- St. Mary's Duluth Clinic
- Ellis Fischel Cancer Center
- St. Louis University, Dept. of Ob-Gyn and Women's Health
- Gynecology & Oncology Consultants, PC
- Saint John's Mercy Hospital
- Deaconess Billings Clinic
- Hematology & Oncology Centers Northern Rockies
- Hematology Oncology Centers of the Northern Rockies
- Horizon's West Medical Group
- Nevada Cancer Center
- Jersey Shore University Medical Center
- The Cancer Institute of New Jersey
- Robert Wood Johnson University Hospital
- UNM Cancer Research and Treatment Center
- Benjamin Schwartz, M.D.
- The Mary Imogene Bassett Hospital
- Med-Onc/Hem
- Hematology-Oncology Associates of Rockland
- Long Island Jewish Medical Center
- North Shore-Long Island Jewish Health System/Medical Center
- Bellevue Hospital Center
- Comprehensive Cancer Center Medical Practice Offices
- New York University Medical Center - Tisch Hospital
- NYU School of Medicine
- Memorial Sloan Kettering Cancer Center
- The Union State Bank Cancer Center at Nyack Hospital
- Gynecologic-Oncology
- Good Samaritan Hospital Medical Center
- South Bay OB/GYN
- Blumenthal Cancer Center
- Presbyterian Gynecologic Oncology
- Presbyterian Hospital Center for Cancer Research
- Piedmont Hematology Oncology Assoc., PA-Salem Research Group
- Salem Research Group, Inc.
- Wake Forest University School of Medicine
- Mid Dakota Clinic
- Odyssey Research Services
- Dakota Cancer Institute
- Odyssey Research Services
- Oncology/Hematology Care, Inc.
- Barrett Cancer Center
- Barrett Cancer Center
- Oncology/Hematology Care, Inc.
- UC Physician's Medical Arts Bldg.
- UC Physician's Medical Arts Building
- University Hospital
- Oncology/Hematology Care, Inc.
- Oncology/Hematology Care, Inc.
- Oncology/Hematology Care, Inc.
- Metro Health Medical Center
- MetroHealth Medical Center
- Mid-Ohio Oncology Hematology St. Anne's
- Mid Ohio Oncology Hematology
- Mid-Ohio Oncology Hematology
- Gynecologic Oncology
- Mount Carmel Health
- Wright State Univ. School of Medicine
- Hillcrest Hospital Cancer Center
- OU Medical Center - Everett Tower
- OU Physicians' Bldg.
- Presbyterian
- University of Oklahoma Health Sciences Center
- Kaiser Permanente Nw, Oncology Research
- Oregon Health & Science University
- Oregon Health Science University
- Abington Mem. Hospita/Rosenfield Cancer Center
- Advanced Imaging
- Hematology & Oncology Associates of NEPA
- Magee-Womens Hospital
- Viewmont Medical Services
- Community Medical Center
- Mercy Health Partners
- Moses Taylor Hospital
- Associates in Hematology-Oncology, P.C.
- Carolina Center of Gynecologic Oncology, PA
- South Carolina Oncology Associates, PA
- Gynecologic Oncology Research and Development
- Gynecologic Oncology Research and Development
- Sioux Valley Clinic Clinical Research Center
- Sioux Valley Clinic Oncology
- Sioux Valley Hospital - North Center Radiology
- Sioux Calley Clinic OBGYN Ltd.
- Chattanooga Oncology & Hematology Associates, P.C.
- Memorial Hospital
- The Consultant Group
- The Sarah Cannon Cancer Center/Tennessee Oncology, PLLC
- The Sarah Cannon Cancer Center/Tennessee Oncology, PLLC
- Saint Mary's Health System, Inc.
- Hall and Martin, M.D.'s, P.C.
- Fort Sanders Parkwest Medical Center
- The Sarah Cannon Cancer Center/Tennessee Oncology, PLLC
- The Sarah Cannon Cancer Center/Tennessee Oncology, PLLC
- The Sarah Cannon Cancer Center/Tennessee Oncology, PLLC
- The Consultant Group
- The Sarah Cannon Cancer Center/Tennessee Oncology, PLLC
- The Sarah Cannon Cancer Center/Tennessee Oncology, PLLC
- The Sarah Cannon Cancer Center/Tennessee Oncology, PLLC
- The Sarah Cannon Cancer Center/Tennessee Oncology, PLLC
- Amarillo Cancer Center
- Arlington Cancer Center
- Dallas Oncology Consultants
- Texas Cancer Associates
- Texas Oncology, PA
- Southwest Fort Worth Cancer Center
- Univ. of TX, MD Anderson Cancer Center
- Danville Hematology and Oncology, Inc.
- Western Washington Oncology
- Western Washington Oncology
- Covington Multicare - Oncology Clinic
- Western Washington Oncology
- Western Washington Oncology
- Western Washington Oncology
- Allenmore Hospital - Hematology Oncology Clinic
- MultiCare Health System - Medical Oncology
- Chippewa Falls Cancer Center
- Regional Cancer Center
- Marshfield Clinic Research Foundation
- Saint Joseph's Hospital
- Wisconsin Rapid Cancer Center
- Merrill Cancer Center
- Medical Consultants, Ltd.
- Marshfield Clinc - Lakeland Center
- Marshfield Clinic - Lakeland Center
- Diagnostic Radiology Associates
- Lakeview Medical Center
- Marshfield Clinic - Indianhead Center
- Saint Michael Hospital
- Wausau Cancer Center
- Hematology Oncology Centers of the Northern Rockies
- Hematology Oncology of the Northern Rockies
- Hospital Italiano Regional del Sur
- Hospital General de Agudos Donacion F. Santojanni
- Hospital Universitario Austral
- Hospital Donacion Francisco Santojanni
- Complejo Medico de la Policia Federal Argentina "Churruca-Visca"
- Hospital Italiano de Buenos Aires
- Sanatorio Municipal Dr. Julio Mendez
- Hospital General de Agudos "Carlos G. Durand"
- Complejo Medico de la Policia Federal Argentina "Churruca-Visca"
- Hospital de Oncologia Maria Curie
- Policlinica Privada Instituto de Medicina Nuclear
- Sociedad de Beneficencia Hospital Italiano
- ISIS Clinica Especializada
- Algemeen Ziekenhuis Antwerpen
- Universitaire Ziekenhuis Antwerpen
- University Hospital Gasthuisberg
- AZ-VUB Dienst Oncologie
- Cliniques Universitaires Saint-Luc
- Universitair Ziekenhuis Gent.
- Centre Hospitalier Regional de la Citadelle
- Instituto do Cancer do Ceara
- Hospital Vera Cruz
- Hospital Luxemburgo
- Hospital de Clinicas de Porto Alegre
- Hospital de Clinicas da Universidade Federal do Parana
- Centro de Tratamento Oncologico de Londrina
- Instituto Arnaldo Vieira de Carvalho
- Hospital das Clinicas de Sao Paulo-FMUSP
- INCA Hospital de Oncologia Clinica
- Hospital do Cancer - A.C. Camargo
- Instituto de Saude e Bem Estar da Mulher
- Unifesp/Epm
- Servicio de Oncologia-Hospital Clinico Unversidad de Chile
- Clinica Santa Maria
- Fakultni nemocnice Olomouc, Onkologicka klinika
- Krajska nemocnice Pardubice, Oddeleni radiacni onklogie
- Fakultni Nemocnice - Onkologicka Klinika
- Vseobecna Fakultni Nemocnice - Onkologicka Klinika
- Batova krajska nemocnice Zlin, prispevkova organizace, Onkologicke oddeleni
- Batova krajska nemocnice Zlin, prispevkova organizace, Radiodiagnosticke oddeleni
- Masarykuv Onkologicky Ustav
- Fakultni nemocnice, Onkologicka klinika
- Universitatsklinikum Charite - Campus Virchow-Klinikum
- St. Vincentius Kliniken
- St. Vincentius Kliniken - Frauenkinik
- St. Vincentius Kliniken - Radiology
- Klinikum GroBhadern-Institut fur Radiologie
- Klinikum GroBhadern-Zentrum fur Frauenheilkunde
- Universitaets-Frauenklinik Ulm
- Dr. Horst-Schmidt-Kliniken GmbH
- Semmelweis University, 1st Dept. of Obstetrics and Gynaecology
- Uzsoki Street Hospital Dept. of Radiooncology
- Faculty of Gynaecologycal Oncology/Univ. of Debrecen
- Baranya County Hospital
- Baranya County Hospital - Department of Oncology
- Baranya County Hospital - Department of Radiology
- SZTE, Department of Oncotherapy
- Oncology Dept., University Floor, Belfast City Hospital
- Vrije Universiteit Medical Centre (VUMC)
- University Medical Centre Nijmegen (UMCN)
- Panorama Medical Centre
- Hopelands Cancer Centre
- Medical and Dental Centre
- Rosebank Oncology Centre
- Wilgers Oncology Centre
- Eastern Cape Oncology Research Centre
- Servicio Oncologia Hospital General Vall d'HebronPaseo
- Instituto Valenciano de Oncologia (IVO)
- Hospital Clinic i Provincial de Barcelona - Servicio de Oncologia Medica
- Hospital Clinic i Provincial
- Hospital General de Guadalajara
- Servicio de Oncologia
- Instituto Valenciano de Oncologia (IVO) Servicio de Oncologia
- Instituto Valenciano de Oncologia (IVO) Servicio de Radiologia
- Department of Cancer Medicine - Ninewells Hospital & Medical School
- Dept. of Med. Oncology/The Royal Marsden Hospital
- St. Chad's Outpatients Unit, City Hospital
- United Bristol Healthcare Trust - Bristol Oncology Centre
- Beatson Oncology Centre
- Beatson Oncology Unit
- Medical Oncology - Guy's and St. Thomas' Hospital
- Department of Medicine-Royal Marsden Hospital
- Department of Medical Oncology, Christie Hospital
- Medical Oncology (NCCT) - Newcastle General Hospital
- Dorset Cancer Centre - Poole Hospital
- Velindre NHS Trust - Velindre Hospital