Change from baseline in BMI (Body Mass Index) at 3 months
BMI will be calculated with weight and height combined in kg/m^2.
Change from baseline in BMI (Body Mass Index) at 6 months
BMI will be calculated with weight and height combined in kg/m^2.
Change from baseline in Waist and hip circumference at 3 months
Waist and hip circumference will take down in centimeters.
Change from baseline in Waist and hip circumference at 6 months
Waist and hip circumference will take down in centimeters.
Change from baseline in blood pressure at 3 months
The unit of measurement of blood pressure is mmHg. Both systolic and diastolic blood pressure will be measured.
Change from baseline in blood pressure at 6 months
The unit of measurement of blood pressure is mmHg. Both systolic and diastolic blood pressure will be measured.
Change from baseline in levels of FPG (Fasting Plasma Glucose) at 3-months
Fasting blood samples will be collected to examine variation in FPG in uIU/mL.
Change from baseline in levels of FPG at 6-months
Fasting blood samples will be collected to examine variation in FPG in uIU/mL.
Change from baseline in levels of serum insulin at 3-months
Fasting blood samples will be collected to examine variation in serum insulin in uIU/mL.
Change from baseline in levels of serum insulin at 6-months
Fasting blood samples will be collected to examine variation in serum insulin in uIU/mL.
Change from baseline in levels of HbA1c (Hemoglobin A1C) at 3-months
Fasting blood samples will be collected to investigate the levels of HbA1c in %.
Change from baseline in levels of HbA1c at 6-months
Fasting blood samples will be collected to investigate the levels of HbA1c in %.
Change from baseline in levels of HOMA-IR (Homeostatic Model Assessment for Insulin Resistance) at 3-months
The equation of HOMA-IR=(insulin (mIU/L) and glucose (mg/dL))/405)
Change from baseline in levels of HOMA-IR at 6-months
The equation of HOMA-IR=(insulin (mIU/L) and glucose (mg/dl))/405)
Change from baseline in levels of HOMA-β (Homeostatic Model Assessment for β-cell function) at 3-months
The equation of HOMA-β=20 × fasting insulin (μIU/ml)/fasting glucose (mmol/ml) - 3.5
Change from baseline in levels of HOMA-β (Homeostatic Model Assessment for β-cell function) at 6-months
The equation of HOMA-β=20 × fasting insulin (μIU/ml)/fasting glucose (mmol/ml) - 3.5
Change from baseline in levels of QUICKI (Quantitative Insulin Sensitivity Check Index) at 3-months
The equation of QUICKI=1 / [log(Fasting Insulin (µU/ml) + log(Fasting Glucose (mg/dL))]
Change from baseline in levels of QUICKI (Quantitative Insulin Sensitivity Check Index) at 6-months
The equation of QUICKI=1 / [log(Fasting Insulin (µU/ml) + log(Fasting Glucose (mg/dL))]
Change from baseline in the level of GA (Glycated albumin) at 3-months
Blood samples will be collected to examine changes in GA in mg/dL.
Change from baseline in the level of GA (Glycated albumin) at 6-months
Blood samples will be collected to examine changes in GA in mg/dL.
Change from baseline in the level of CRE (Creatinine) at 3-months
Blood samples will be collected to examine changes in CRE in mg/dL.
Change from baseline in the level of CRE at 6-months
Blood samples will be collected to examine changes in CRE in mg/dL.
Change from baseline in the level of BUN (Blood Urea Nitrogen) at 3-months
Blood samples will be collected to examine changes in BUN in mg/dL.
Change from baseline in the level of BUN at 6-months
Blood samples will be collected to examine changes in BUN in mg/dL.
Change from baseline in the level of K+ (Potassium) at 3-months
Blood samples will be collected to examine changes from baseline in K+ in mg/dL.
Change from baseline in the level of K+ at 6-months
Blood samples will be collected to examine changes from baseline in K+ in mg/dL.
Change from baseline in the level of Urine protein/albumin at 3-months
Urine samples will be collected to examine changes in Urine protein/albumin in mg/dL.
Change from baseline in the level of Urine protein/albumin at 6-months
Urine samples will be collected to examine changes in Urine protein/albumin in mg/dL.
Change from baseline in the level of Urine microalbuminuria/creatinine at 3-months
Urine samples will be collected to examine changes from baseline in Urine protein/albumin in mg/dL.
Change from baseline in the level of Urine microalbuminuria/creatinine at 6-months
Urine samples will be collected to examine changes from baseline in Urine protein/albumin in mg/dL.
Change from baseline in the level of Urine acid at 3-months
Urine samples will be collected to examine changes in Urine protein/albumin in mg/dL.
Change from baseline in the level of Urine acid at 6-months
Urine samples will be collected to examine changes in Urine protein/albumin in mg/dL.
Change from baseline in the level of CG (The Cockcroft and Gault formula) at 3-months
CG will be calculated with creatinine, age, weight, gender. The equation of CG = (((140 - age in years) x (weight in kg)) x 1.23) / (serum creatinine in micromol/l).
Change from baseline in the level of CG at 6-months
CG will be calculated with creatinine, age, weight, gender. The equation of CG = (((140 - age in years) x (weight in kg)) x 1.23) / (serum creatinine in micromol/l).
Change from baseline in the level of eGFR (Estimated Glomerular Filtration Rate) at 3-months
eGFR will be estimated according to the CKD-EPI Creatinine Equation (2021) which is calculated with serum creatinine, Cystatin C, age, gender.
Change from baseline in the level of eGFR (Estimated Glomerular Filtration Rate) at 6-months
eGFR will be estimated according to the CKD-EPI Creatinine Equation (2021) which is calculated with serum creatinine, Cystatin C, age, gender.
Change from baseline in levels of blood lipid-related Index at 3 months
Blood samples will be collected to examine variation in TG (Triglyceride), TC (Total Cholesterol), VLDL (Very-Low-Density Lipoprotein), LDL (Low-density lipoprotein), HDL (High-density lipoprotein).
Change from baseline in levels of blood lipid-related Index at 6 months
Blood samples will be collected to examine variation in TG (Triglyceride), TC (Total Cholesterol), VLDL (Very-Low-Density Lipoprotein), LDL (Low-density lipoprotein), HDL (High-density lipoprotein).
Change from baseline in levels of cytokines Index at 3 months
Blood samples will be collected to examine variation in hs-CRP (high-sensitivity C-reactive protein), IL-6 (Interleukin-6), IL-18 (Interleukin-18), IL -1-α (Interleukin-1-α), IL-1β (Interleukin-1 β), TNF-α (Tumor necrosis factor-α), NGAL (Neutrophil Gelatinase-Associated Lipocalin), sTNFR1 (Soluble tumour necrosis factor receptor-1), PGRN (Progranulin). All the indexes will be recorded in in pg/mL.
Change from baseline in levels of cytokines Index at 6 months
Blood samples will be collected to examine variation in hs-CRP, IL-6, IL-18, IL-1-α, IL-1β, TNF-α, NGAL, sTNFR1, PGRN. All the indexes will be recorded in in pg/mL.
Change from baseline in levels of TIBC (Total Iron-Binding Capacity) at 3-months
TIBC will be calculated by summing the values of serum iron and UIBC(unsaturated iron-binding capacity) which is examed from blood samples.
Change from baseline in levels of TIBC at 6-months
TIBC will be calculated by summing the values of serum iron and UIBC which is examed from blood samples.
Change from baseline in the level of SCFA (Short Chain Fatty Acids) at 6 months
Stool samples will be collected to examine variation in SCFA (Short Chain Fatty Acids).
Change from baseline in the level of TMAO (Trimethylamine N-oxide) at 3-months
Blood samples will be collected to examine variation in TMAO in μmol/L.
Change from baseline in the level of TMAO at 6-months
Blood samples will be collected to examine variation in TMAO in μmol/L.
Change from baseline in self-record of the International physical activity questionary (IPAQ) in physical assessment at 6 months
The questionnaire will be recorded the laborious activity by the subject himself/herself before and after the treatment.
Change from baseline in gut microbiota at 6 months
The analysis of Gut microbiota will utilize DNA sequencing to investigate the intestinal microbiota through stool samples.