Tobacco Dependence in Alcoholism Treatment (Nicotine Patch/Naltrexone)
Alcoholism, Smoking
About this trial
This is an interventional treatment trial for Alcoholism
Eligibility Criteria
Inclusion Criteria: Meets criteria for alcohol dependence and nicotine dependence. Expresses a desire to cut down or stop drinking and smoking. Exclusion Criteria: Currently meets criteria for dependence on substances other than alcohol and nicotine. Any history of opiate dependence or evidence of current opiate use. Significant medical disorders that will increase potential risk or interfere with study participation. Liver function tests more than 3 times normal or elevated bilirubin. Females who are pregnant, nursing, or not using a reliable method of birth control. Meets criteria for a major psychiatric disorder and is in need of or currently undergoing drug therapy. Inability to understand and/or comply with the provisions of the protocol and consent form. Treatment with an investigational drug during the previous month. Chronic treatment with any narcotic-containing medications during the previous month. Sensitivity to drug as evidenced by adverse drug experiences especially with narcotic- containing analgesics or opioid antagonists. Current treatment with disulfiram (Antabuse) or nicotine replacement therapy. More than 6 weeks of abstinence.
Sites / Locations
- Department of Psychiatry, University of Miami School of Medicine
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Experimental
Active Comparator
Active Comparator
Placebo Comparator
Naltrexone Tablet and Nicotine Patch
Naltrexone Tablet and Placebo Patch
Placebo Tablet and Nicotine Patch
Placebo Tablet and Placebo Patch