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Toolkit for Optimal Recovery After Orthopedic Injury (TOR)

Primary Purpose

Acute Orthopedic Injury

Status
Recruiting
Phase
Not Applicable
Locations
United States
Study Type
Interventional
Intervention
Toolkit for Optimal Recovery after Orthopedic Injury
Minimally Enhanced Usual Care (MEUC)
Sponsored by
Massachusetts General Hospital
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional prevention trial for Acute Orthopedic Injury focused on measuring Mind-Body, Pain, Physical Function, Disability, Psychosocial

Eligibility Criteria

18 Years - undefined (Adult, Older Adult)All SexesDoes not accept healthy volunteers

Inclusion Criteria:

  1. Male and female outpatients in the Level 1 Trauma Center of one of the 3 sites, age 18 years or older
  2. Sustained a single acute orthopedic injury (e.g., fracture, dislocation, rupture) approximately 1-2 months earlier (acute phase)
  3. Score ≥20 on the Pain Catastrophizing Scale (PCS) or ≥40 on the Short Form Pain Anxiety Scale (PASS-20)
  4. Willing to participate and comply with the requirements of the study protocol, including randomization, questionnaire completion, and potential home practice and weekly sessions.
  5. Free of concurrent psychotropic medication for at least 2 weeks prior to initiation of treatment, OR stable on current psychotropic medication for a minimum of 6 weeks and willing to maintain a stable dose (i.e., no psychotropics or stable for >6 weeks)
  6. Cleared by the orthopedic surgeons for study participation.
  7. Able to meaningfully participate (e.g., English speaking and comprehension, stable living situation as determined by the medical staff at each site).

Exclusion Criteria:

  1. Diagnosed with a medical illness expected to worsen in the next 3 months (e.g., malignancy)
  2. Serious mental illness or instability for which hospitalization may be likely in the next 3 months
  3. Current suicidal ideation
  4. Other serious injuries that occurred alongside the orthopedic injury
  5. Lifetime history of schizophrenia, bipolar disorder, or other psychotic disorder
  6. Current substance use disorder
  7. Practice of yoga/meditation, or other mind body techniques, once per week for 45 minutes or more within the last 3 months
  8. Currently in litigation or under Workman's Comp
  9. Surgery complications (e.g., infection, need for repeat surgery)
  10. Self-reported pregnancy

Sites / Locations

  • Massachusetts General HospitalRecruiting

Arms of the Study

Arm 1

Arm 2

Arm Type

Experimental

Active Comparator

Arm Label

Toolkit for Optimal Recovery after Orthopedic Injury - Active

Minimally Enhanced Usual Care (MEUC) - Control

Arm Description

The Toolkit (TOR) is a 4-session, individual, live video, synchronous program developed specifically for patients with orthopedic acute injuries who are at risk for chronic pain and disability. The program teaches evidence-based mind-body skills (e.g., relaxation and mindfulness; myths about pain; activity pacing; acceptance and values based goal setting). Participants gain access to a website downloaded on their phones as an app. The website included explainer videos of skills and recordings of mindfulness and relaxation exercises. In addition, participants will receive usual care as determined by medical team.

The MEUC is educational material, in the form of a physical hard-copy pamphlet and website downloaded as an app on their phones. In addition, participants will receive usual care as determined by medical team.

Outcomes

Primary Outcome Measures

Feasibility of recruitment among all patients
We will report number of participants who agree to participate out of those eligible, evaluated at the end of study for all participants.
Appropriateness rated by participants randomized to TOR, assessed by the Credibility and Expectancy Scale
Rate of participant's expectations and believed credibility for program, with range 3 to 27 and higher ratings indicating more belief that the program is logical and will help with the intended outcome.
Feasibility of data collection
We will report number of patients who complete assessments at each time-point.
Acceptability of treatment (satisfaction) assessed with the Client Satisfaction Questionnaire (patients randomized to TOR only)
Participant's satisfaction with treatment received after completion of TOR. Items are summed to generate a total score; scores range from 3 to 12, with higher values indicating higher satisfaction.
Acceptability of TOR (attendance for patients randomized to TOR)
We will report number of sessions attended for participants enrolled to TOR.

Secondary Outcome Measures

Feasibility of randomization/adherence to assigned arm for all enrolled patients all enrolled patients
We will report number of participants who are randomized within one arm and complete post-test.
Orthopedic staff feasibility of referral
We will report number of surgeons who make at least 5 referrals per site. We will keep track of the referring source and report number of referrals made by each surgeon.
Fidelity to study procedures
We will report number of protocol deviations per site among all enrolled patients.
Adherence to TOR homework
We will report number of homework logs that are returned with 4 out of 7 days of practice among patients randomized to TOR.
Acceptability as rated by therapist
We will report number of participants who score over 7 out of 10 on the therapist rating of participation quality in each session among patients randomized to TOR.
Perceived acceptability for those who completed the satisfaction measures
We will report number of surgeons and staff who score over 7 on satisfaction measure, among completers.
Perceived acceptability of staff regarding ease of referral
We will report number of surgeons and staff who score over 7 on ease of referral measure, among completers.
Perceived acceptability of staff regarding cost-benefit
We will report number of surgeons and staff who score over 7 on cost-benefit measure, among completers.
Feasibility of study implementation as perceived by study staff
We will report number of surgeons and staff who score over 7 on Feasibility of study implementation as perceived by study staff who completed measures.
Appropriateness as perceived by study staff
We will report number of surgeons and staff who score over 7 on Appropriateness as perceived by study staff who completed measures.
Feasibility of collecting Orthopedic staff satisfaction measures
We will report number of surgeons and study staff who complete the measure.
Feasibility of obtaining data on Orthopedic staff perceived ease of referrals
We will report number of surgeons and study staff who complete the measure.
Feasibility of obtaining data on Orthopedic staff perceived cost-benefit
We will report number of surgeons and study staff who complete the measure.
Feasibility of collecting data on feasibility of study implementation
We will report number of surgeons and staff who complete the data.
Feasibility of collecting appropriateness measures
We will report number of surgeons and staff who complete appropriateness measure.
Numerical Rating Scale
Rate of participant's pain at rest and with activity using the Numerical Rating Scale, a Likert scale with 0 being no pain and 10 being the worst possible pain.
Physical function self-report
The PROMIS Physical Function (v1.0 8b) assesses one's ability to carry out activities that require physical actions ranging from self-care to social and work. Items ranging from 1-4, and total scores ranging from 8-40, with a higher score reflect greater physical function.
Physical function performance-based
The Timed 10 Meter Walk Test will be used for those with lower extremity injury or body injury, which measures how fast one can walk 10 meters, which is a valid indicator for evaluating the physical function. The Grip Test using a dynamometer will be used for those with upper extremity injuries and measures the amount of muscular strength or the maximum force/tension generated by one's forearm muscles, as a method for assessing physical function.
Coping and emotional function
The Center for Epidemiologic Study of Depression (CES-D), a 20-item measure assesses depressive symptomatology; scores range from 0-60 and higher scores indicate greater depressive symptomatology. The 17-item PTSD Checklist civilian measure assesses post-traumatic stress; scores range from 17-85 with higher scores indicating greater post-traumatic stress. The Pain Catastrophizing Scale (PCS), a 13-item measure assesses hopelessness, helplessness and rumination about pain, with items ranging from 0-4 and total scores ranging from 0-52, with higher scores indicating higher levels of pain catastrophizing. The Pain Anxiety Scale, short form (PASS-20) assesses cognitive and somatic symptoms of anxiety, items range from 0-100 and higher scores indicating greater pain anxiety. The Measure of Current Status (MOCS-A) assesses ability to engage in healthy coping skills, with items ranging from 0-4, total score ranging from 0-52, and higher scores reflecting more usage of general coping skills.
Feasibility of data collection for performance based measures of physical function (walk/grip test) at each of the 3 time points
We will report number of enrolled participants who will have complete for performance based measures of physical function (Walk/Grip test).
Feasibility of data collection of rescue analgesics (non-narcotic)
We will report number of participants with complete data on rescue analgesics (non-narcotic) among enrolled patients with orthopedic injuries via self-report log.
Feasibility of data collection of rescue analgesics (narcotic)
We will report number of participants with complete data on rescue analgesics (narcotic) among enrolled patients with orthopedic injuries via self-report log.
Adverse events
We will report number of adverse events among all enrolled patients with orthopedic injuries.
Feasibility of data collection of adverse events
We will report number of participants with complete data on adverse events among enrolled patients with orthopedic injuries.
Therapist adherence/fidelity to session
We will report number of participants who present ≥75 adherence (checklist and audio recordings).
Within group change in rescue analgesics (non-narcotic)
Self-report of past-week rescue analgesics use collected before each intervention session.
Within group change in narcotic analgesics
Self-report of past-week narcotic rescue analgesics use collected before each intervention session.

Full Information

First Posted
July 13, 2021
Last Updated
February 10, 2023
Sponsor
Massachusetts General Hospital
Collaborators
University of Texas at Austin, University of Kentucky, Vanderbilt University Medical Center
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1. Study Identification

Unique Protocol Identification Number
NCT04973696
Brief Title
Toolkit for Optimal Recovery After Orthopedic Injury
Acronym
TOR
Official Title
Toolkit for Optimal Recovery After Orthopedic Injury; A Multisite Feasibility Study to Prevent Persistent Pain and Disability
Study Type
Interventional

2. Study Status

Record Verification Date
February 2023
Overall Recruitment Status
Recruiting
Study Start Date
September 15, 2021 (Actual)
Primary Completion Date
August 15, 2023 (Anticipated)
Study Completion Date
August 15, 2023 (Anticipated)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Principal Investigator
Name of the Sponsor
Massachusetts General Hospital
Collaborators
University of Texas at Austin, University of Kentucky, Vanderbilt University Medical Center

4. Oversight

Studies a U.S. FDA-regulated Drug Product
No
Studies a U.S. FDA-regulated Device Product
No

5. Study Description

Brief Summary
This is a multi-site randomized feasibility trial of the Toolkit for Optimal Recovery after Orthopedic Injury (TOR), a mind-body program to prevent persistent pain and disability in at-risk patients with acute orthopedic injury, versus a minimally-enhanced usual care (MEUC) control. TOR is a 4-session program delivered via secure live video to patients at risk for chronic pain, 1-2 months after an orthopedic traumatic injury. The primary aim of this study is to determine whether the study methodology (i.e., implementation, randomization, procedures and assessment of outcome measures) and delivery of TOR meet a priori set benchmarks for feasibility, acceptability, and appropriateness, necessary for the success of the subsequent efficacy trial.
Detailed Description
Study Rationale: The care of patients with acute orthopedic injuries follows an outdated biomedical model, and consists primarily of surgical interventions and pain medications, despite strong evidence for the pivotal role of psychosocial factor in transition to persistent pain and disability. We developed the first mind-body program - The Toolkit for Optimal Recovery after orthopedic injury (TOR) - to prevent chronic pain and disability in at-risk patients with orthopedic injuries. TOR is based on the fear avoidance model and teaches skills (e.g., mindfulness and relaxation, adaptive thinking, acceptance) to help optimize recovery. Each TOR session is 45 minutes long, and there are 4 sessions delivered within a period of 4-5 weeks (TOR and control arm will be yoked for the timing of interventions). Primary Objective The primary objective is to conduct a multi-site feasibility RCT of TOR versus MEUC control in order to determine whether the study methodology and TOR meet a priori set benchmarks necessary for the success of the subsequent efficacy trial. There are 5 primary outcomes: 1. Feasibility of recruitment (assessed by number of participants who agree to participate); 2. Appropriateness (assessed with the Credibility and Expectancy Scale); 3. Feasibility of data collection (self-report; assessed by number of participants who complete these measures at the 3 time points); 4. Treatment satisfaction (assessed with the Client Satisfaction Scale); and 5. Acceptability of TOR (adherence to sessions). Hypothesis: We expect that TOR will meet all a priori set benchmarks. Secondary Objectives: There will be 27 secondary outcomes. All will be reported separately for each site (see below). Study Design: In the present study, 180 patients with acute orthopedic injuries from the Level I Trauma Centers at Massachusetts General Hospital (Boston, MA), Dell Medical School (Austin, TX), the University of Kentucky (Lexington, KY), and Vanderbilt University Medical Center (Nashville, TN) who are at risk for chronic pain and disability will be enrolled. After consent and baseline assessments, participants will be randomly assigned to TOR or to a minimally enhanced usual care control (MEUC). Subjects in the TOR group undergo a 4-week session (~45 minutes each), individual, live video, synchronous mind-body intervention. The MEUC group will receive a pamphlet containing brief summarized information that reflects the intervention topics (e.g., the trajectory of pain and recovery after orthopedic illness). In addition, participants in both groups will receive usual medical care as determined by the medical team. Participants in both groups will complete assessments at baseline, after the completion of TOR, and 3 months (from baseline) later.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Acute Orthopedic Injury
Keywords
Mind-Body, Pain, Physical Function, Disability, Psychosocial

7. Study Design

Primary Purpose
Prevention
Study Phase
Not Applicable
Interventional Study Model
Parallel Assignment
Masking
InvestigatorOutcomes Assessor
Masking Description
Research assistants who assess outcomes and collect data after randomization, orthopedic surgeons, and statistician will be blinded. The study clinicians will be unblinded. The research assistant who enrolls participants and performs activities before randomization will be unblinded.
Allocation
Randomized
Enrollment
180 (Anticipated)

8. Arms, Groups, and Interventions

Arm Title
Toolkit for Optimal Recovery after Orthopedic Injury - Active
Arm Type
Experimental
Arm Description
The Toolkit (TOR) is a 4-session, individual, live video, synchronous program developed specifically for patients with orthopedic acute injuries who are at risk for chronic pain and disability. The program teaches evidence-based mind-body skills (e.g., relaxation and mindfulness; myths about pain; activity pacing; acceptance and values based goal setting). Participants gain access to a website downloaded on their phones as an app. The website included explainer videos of skills and recordings of mindfulness and relaxation exercises. In addition, participants will receive usual care as determined by medical team.
Arm Title
Minimally Enhanced Usual Care (MEUC) - Control
Arm Type
Active Comparator
Arm Description
The MEUC is educational material, in the form of a physical hard-copy pamphlet and website downloaded as an app on their phones. In addition, participants will receive usual care as determined by medical team.
Intervention Type
Behavioral
Intervention Name(s)
Toolkit for Optimal Recovery after Orthopedic Injury
Intervention Description
The Toolkit (TOR) is a 4-session, individual, live video, synchronous program developed specifically for patients with orthopedic acute injuries who are at risk for chronic pain and disability. The program teaches evidence-based mind-body skills (e.g., relaxation and mindfulness; myths about pain; activity pacing; acceptance and values based goal setting). Participants gain access to a website downloaded on their phones as an app. The website included explainer videos of skills and recordings of mindfulness and relaxation exercises. In addition, participants will receive usual care as determined by medical team.
Intervention Type
Other
Intervention Name(s)
Minimally Enhanced Usual Care (MEUC)
Intervention Description
The MEUC is educational material, in the form of a physical hard-copy pamphlet and website downloaded as an app on their phones. In addition, participants will receive usual care as determined by medical team.
Primary Outcome Measure Information:
Title
Feasibility of recruitment among all patients
Description
We will report number of participants who agree to participate out of those eligible, evaluated at the end of study for all participants.
Time Frame
throughout the study completion, on average of 2 years
Title
Appropriateness rated by participants randomized to TOR, assessed by the Credibility and Expectancy Scale
Description
Rate of participant's expectations and believed credibility for program, with range 3 to 27 and higher ratings indicating more belief that the program is logical and will help with the intended outcome.
Time Frame
Baseline
Title
Feasibility of data collection
Description
We will report number of patients who complete assessments at each time-point.
Time Frame
throughout the study completion, on average of 3 years
Title
Acceptability of treatment (satisfaction) assessed with the Client Satisfaction Questionnaire (patients randomized to TOR only)
Description
Participant's satisfaction with treatment received after completion of TOR. Items are summed to generate a total score; scores range from 3 to 12, with higher values indicating higher satisfaction.
Time Frame
Post-Test
Title
Acceptability of TOR (attendance for patients randomized to TOR)
Description
We will report number of sessions attended for participants enrolled to TOR.
Time Frame
throughout the study completion, on average of 3 years
Secondary Outcome Measure Information:
Title
Feasibility of randomization/adherence to assigned arm for all enrolled patients all enrolled patients
Description
We will report number of participants who are randomized within one arm and complete post-test.
Time Frame
throughout the study completion, on average of 3 years
Title
Orthopedic staff feasibility of referral
Description
We will report number of surgeons who make at least 5 referrals per site. We will keep track of the referring source and report number of referrals made by each surgeon.
Time Frame
throughout the study completion, on average of 3 years
Title
Fidelity to study procedures
Description
We will report number of protocol deviations per site among all enrolled patients.
Time Frame
throughout the study completion, on average of 3 years
Title
Adherence to TOR homework
Description
We will report number of homework logs that are returned with 4 out of 7 days of practice among patients randomized to TOR.
Time Frame
throughout the study completion, on average of 3 years
Title
Acceptability as rated by therapist
Description
We will report number of participants who score over 7 out of 10 on the therapist rating of participation quality in each session among patients randomized to TOR.
Time Frame
throughout the study completion, on average of 3 years
Title
Perceived acceptability for those who completed the satisfaction measures
Description
We will report number of surgeons and staff who score over 7 on satisfaction measure, among completers.
Time Frame
throughout the study completion, on average of 3 years
Title
Perceived acceptability of staff regarding ease of referral
Description
We will report number of surgeons and staff who score over 7 on ease of referral measure, among completers.
Time Frame
throughout the study completion, on average of 3 years
Title
Perceived acceptability of staff regarding cost-benefit
Description
We will report number of surgeons and staff who score over 7 on cost-benefit measure, among completers.
Time Frame
throughout the study completion, on average of 3 years
Title
Feasibility of study implementation as perceived by study staff
Description
We will report number of surgeons and staff who score over 7 on Feasibility of study implementation as perceived by study staff who completed measures.
Time Frame
throughout the study completion, on average of 3 years
Title
Appropriateness as perceived by study staff
Description
We will report number of surgeons and staff who score over 7 on Appropriateness as perceived by study staff who completed measures.
Time Frame
throughout the study completion, on average of 3 years
Title
Feasibility of collecting Orthopedic staff satisfaction measures
Description
We will report number of surgeons and study staff who complete the measure.
Time Frame
throughout the study completion, on average of 3 years
Title
Feasibility of obtaining data on Orthopedic staff perceived ease of referrals
Description
We will report number of surgeons and study staff who complete the measure.
Time Frame
throughout the study completion, on average of 3 years
Title
Feasibility of obtaining data on Orthopedic staff perceived cost-benefit
Description
We will report number of surgeons and study staff who complete the measure.
Time Frame
throughout the study completion, on average of 3 years
Title
Feasibility of collecting data on feasibility of study implementation
Description
We will report number of surgeons and staff who complete the data.
Time Frame
End of study
Title
Feasibility of collecting appropriateness measures
Description
We will report number of surgeons and staff who complete appropriateness measure.
Time Frame
throughout the study completion, on average of 3 years
Title
Numerical Rating Scale
Description
Rate of participant's pain at rest and with activity using the Numerical Rating Scale, a Likert scale with 0 being no pain and 10 being the worst possible pain.
Time Frame
Baseline (0 Weeks), Post-Test (4 Weeks), Follow-up (3 Months)
Title
Physical function self-report
Description
The PROMIS Physical Function (v1.0 8b) assesses one's ability to carry out activities that require physical actions ranging from self-care to social and work. Items ranging from 1-4, and total scores ranging from 8-40, with a higher score reflect greater physical function.
Time Frame
Baseline (0 Weeks), Post-Test (4 Weeks), Follow-up (3 Months)
Title
Physical function performance-based
Description
The Timed 10 Meter Walk Test will be used for those with lower extremity injury or body injury, which measures how fast one can walk 10 meters, which is a valid indicator for evaluating the physical function. The Grip Test using a dynamometer will be used for those with upper extremity injuries and measures the amount of muscular strength or the maximum force/tension generated by one's forearm muscles, as a method for assessing physical function.
Time Frame
Baseline (0 Weeks), Post-Test (4 Weeks), Follow-up (3 Months)
Title
Coping and emotional function
Description
The Center for Epidemiologic Study of Depression (CES-D), a 20-item measure assesses depressive symptomatology; scores range from 0-60 and higher scores indicate greater depressive symptomatology. The 17-item PTSD Checklist civilian measure assesses post-traumatic stress; scores range from 17-85 with higher scores indicating greater post-traumatic stress. The Pain Catastrophizing Scale (PCS), a 13-item measure assesses hopelessness, helplessness and rumination about pain, with items ranging from 0-4 and total scores ranging from 0-52, with higher scores indicating higher levels of pain catastrophizing. The Pain Anxiety Scale, short form (PASS-20) assesses cognitive and somatic symptoms of anxiety, items range from 0-100 and higher scores indicating greater pain anxiety. The Measure of Current Status (MOCS-A) assesses ability to engage in healthy coping skills, with items ranging from 0-4, total score ranging from 0-52, and higher scores reflecting more usage of general coping skills.
Time Frame
Baseline (0 Weeks), Post-Test (4 Weeks), Follow-up (3 Months)
Title
Feasibility of data collection for performance based measures of physical function (walk/grip test) at each of the 3 time points
Description
We will report number of enrolled participants who will have complete for performance based measures of physical function (Walk/Grip test).
Time Frame
Duration of project, (two years)
Title
Feasibility of data collection of rescue analgesics (non-narcotic)
Description
We will report number of participants with complete data on rescue analgesics (non-narcotic) among enrolled patients with orthopedic injuries via self-report log.
Time Frame
Duration of project, (two years)
Title
Feasibility of data collection of rescue analgesics (narcotic)
Description
We will report number of participants with complete data on rescue analgesics (narcotic) among enrolled patients with orthopedic injuries via self-report log.
Time Frame
Duration of project, (two years)
Title
Adverse events
Description
We will report number of adverse events among all enrolled patients with orthopedic injuries.
Time Frame
Duration of project, (two years)
Title
Feasibility of data collection of adverse events
Description
We will report number of participants with complete data on adverse events among enrolled patients with orthopedic injuries.
Time Frame
Duration of project, (two years)
Title
Therapist adherence/fidelity to session
Description
We will report number of participants who present ≥75 adherence (checklist and audio recordings).
Time Frame
Duration of project, (two years)
Title
Within group change in rescue analgesics (non-narcotic)
Description
Self-report of past-week rescue analgesics use collected before each intervention session.
Time Frame
Baseline (0 Weeks), Post-Test (4 Weeks), Follow-up (3 Months)
Title
Within group change in narcotic analgesics
Description
Self-report of past-week narcotic rescue analgesics use collected before each intervention session.
Time Frame
Baseline (0 Weeks), Post-Test (4 Weeks), Follow-up (3 Months)

10. Eligibility

Sex
All
Minimum Age & Unit of Time
18 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria: Male and female outpatients in the Level 1 Trauma Center of one of the 4 sites, age 18 years or older Sustained one more more acute orthopedic injuries (e.g., fracture, dislocation, rupture) approximately 1-2 months earlier (acute phase) Score ≥20 on the Pain Catastrophizing Scale (PCS) or ≥40 on the Short Form Pain Anxiety Scale (PASS-20) Willing to participate and comply with the requirements of the study protocol, including randomization, questionnaire completion, and potential home practice and weekly sessions. No psychotropics for at least 2 weeks prior to initiation of treatment or stable for >6 weeks and willing to maintain a stable dose Cleared by orthopedic surgeon for activities using the injured limb within the next 4 weeks Able to meaningfully participate (e.g., English speaking and comprehension, stable living situation as determined by the medical staff at each site) A score of 8/10 or more on the Short Portable Mental Status Questionnaire ONLY IF a participant is 65 or older, or if a participant's cognitive abilities are unclear to research staff Exclusion Criteria: Serious comorbidity expected to worsen in the next 3 months (e.g., malignancy) Current untreated or unstable severe mental health conditions like bipolar disorder, schizophrenia, or active substance use Current suicidal ideation Other unmanaged serious non-orthopedic injuries that occurred alongside the orthopedic injury (i.e., TBI, ruptured internal organs, etc.) Practice of meditation, or other mind body techniques that elicit the RR, for at least 45 total minutes a week each week over the last 3 months Currently in litigation or under Workman's Comp Surgery complications (e.g., uncontrolled infection, need for repeat surgery) Self-reported pregnancy
Central Contact Person:
First Name & Middle Initial & Last Name or Official Title & Degree
Ana-Maria Vranceanu, PhD
Phone
6176437996
Email
avranceanu@mgh.harvard.edu
First Name & Middle Initial & Last Name or Official Title & Degree
Jafar Bakhshaie, MD,PhD
Email
jbakhshaie@mgh.harvard.edu
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Ana-Maria Vranceanu, PhD
Organizational Affiliation
Massachusetts General Hospital
Official's Role
Principal Investigator
Facility Information:
Facility Name
Massachusetts General Hospital
City
Boston
State/Province
Massachusetts
ZIP/Postal Code
02140
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Ana-Maria Vranceanu, PhD

12. IPD Sharing Statement

Learn more about this trial

Toolkit for Optimal Recovery After Orthopedic Injury

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